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Cellosaurus NPLC/PRF/5 (CVCL_B449)

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Cell line name NPLC/PRF/5
Synonyms N-PLC/PRF/5
Accession CVCL_B449
Resource Identification Initiative To cite this cell line use: NPLC/PRF/5 (RRID:CVCL_B449)
Comments Population: African; Shangaan.
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg112Gly (c.334C>G) (p.Pro126Arg, c.377C>G); ClinVar=VCV000233484; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:12363; TSC2; Simple; p.Asn1651Ser (c.4952A>G); ClinVar=VCV000049335; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0485 (PLC/PRF/5)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
Publications

PubMed=2827003; DOI=10.1128/mcb.8.1.25-34.1988; PMCID=PMC363074
Cathleen R. Carlin, Daniela Simon, James Mattison, Barbara B. Knowles;
Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.
Mol. Cell. Biol. 8:25-34(1988)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B449
Anatomy/cell type resources BTO; BTO_0002906
Encyclopedic resources Wikidata; Q54930996
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number18