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Cellosaurus (CVCL_XB33)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: NCI RAS program mutant KRAS cell line panel.
From: Johns Hopkins University School of Medicine; Baltimore; USA.
Population: Caucasian.
Doubling time: 20.0 hours (PubMed=9612602); 117 hours (PubMed=25984343).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (PubMed=9612602; ATCC=CRL-2551).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Cys123Metfs*2 (c.366dupA) (c.366_367insA); Zygosity=Homozygous (ATCC=CRL-2551).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*07:02,15:40
HLA-CC*02:02,05:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.26
Native American0.57
East Asian, North2.49
East Asian, South0
South Asian0
European, North62.31
European, South32.37
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 85Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2551; Cosmic-CLP=925347; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D2S133817,18
D3S135816
D5S81813,14
D7S82011
D8S117910,14
D13S31713
D16S53913
D18S5119
D19S43313
D21S1132.2
FGA21,23
Penta D10
Penta E5,16,17
TH016,9.3
TPOX8,12
vWA18

Run an STR similarity search on this cell line
Publications





Gerd Scherer;
A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3.
Cytogenet. Cell Genet. 76:172-175(1997)




Cancer Chemother. Pharmacol. 43:198-204(1999)


Anneke B. Oostra, Aggie W.M. Nieuwint, Johan P. de Winter, Maureen E. Hoatlin, Yohko Kawai, Masao S. Sasaki, Alan David D'Andrea, Yutaka Kawakami, Hans Joenje;
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2.
Cancer Res. 63:2688-2694(2003)




Cancer Res. 66:2584-2591(2006)




Nat. Biotechnol. 26:1269-1275(2008)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)



Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma.
Br. J. Cancer 102:1618-1626(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Warren Fiskus, Srdan Verstovsek, Taghi Manshouri, Rekha Rao, Ramesh Balusu, Sreedhar Venkannagari, Narasimharao Nalabothula, Kyungsoo Ha, Jacqueline E. Smith, Stacey L. Hembruff, Sunil Abhyankar ...Show all 13 authors... , Joseph Patrick McGuirk, Kapil N. Bhalla; Show fewer authors
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
Clin. Cancer Res. 17:7347-7358(2011)


Pedro G. Ferreira, Matthias Barann, Thomas Wieland, Liliana Greger, Maarten van Iterson, Jonas Carlsson Almlof, Paolo Ribeca, Irina Pulyakhina, Daniela Esser, Thomas Giger, Andrew Tikhonov ...Show all 48 authors... , Marc Sultan, Gabrielle Bertier, Daniel Geoffrey MacArthur, Monkol Lek, Esther Lizano, Henk P.J. Buermans, Ismael Padioleau, Thomas Schwarzmayr, Olof Karlberg, Halit Ongen, Helena Kilpinen, Sergi Beltran, Marta Gut, Katja Kahlem, Vyacheslav Amstislavskiy, Oliver Stegle, Matti Pirinen, Stephen B. Montgomery, Peter Donnelly, Mark Ian McCarthy, Paul Flicek, Tim-Matthias Strom, Hans Lehrach, Stefan Schreiber, Ralf Sudbrak, Angel Carracedo, Stylianos E. Antonarakis, Robert Hasler, Ann-Christine Syvanen, Gert-Jan B. van Ommen, Alvis Brazma, Thomas Meitinger, Philip Rosenstiel, Roderic Guigo, Ivo G. Gut, Xavier Estivill, Emmanouil Theophilos Dermitzakis; Show fewer authors
Geuvadis Consortium
Transcriptome and genome sequencing uncovers functional variation in humans.
Nature 501:506-511(2013)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)




Cancer Immunol. Immunother. 65:485-492(2016)


Thomas Graf;
Erratum to 'C/EBPalpha induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity'.
Cell Rep. 19:1281-1281(2017)



literature.
Cancer Res. 77:2784-2788(2017)


Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A. Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal J. Patel ...Show all 27 authors... , Alistair White, Sharad R. Patel, Laura Clarke, Reena Halai, Christopher Michael Kirton, Anja Kolb-Kokocinski, Philip L. Beales, Ewan Birney, Davide Danovi, Angus Iain Lamond, Willem Hendrik Ouwehand, Ludovic Vallier, Fiona Mary Watt, Richard Michael Durbin, Oliver Stegle, Daniel J. Gaffney; Show fewer authors
Common genetic variation drives molecular heterogeneity in human iPSCs.
Nature 546:370-375(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)


Katsushi Tokunaga, Masao Nagasaki, Seiji Kito, Keiichi Isoyama, Masafumi Onodera, Hideo Kaneko, Naomichi Matsumoto, Fumihiko Matsuda, Keitaro Matsuo, Yoshiyuki Takahashi, Tomoji Mashimo ...Show all 13 authors... , Seiji Kojima, Tomoo Ogi; Show fewer authors
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Sci. Adv. 6:eabd7197.1-eabd7197.15(2020)

Cross-references
Cell line databases/resources Cosmic-CLP; 925347
DepMap; ACH-000417
LINCS_LDP; LCL-1742
Chemistry resources GDSC; 925347
PharmacoDB; Panc08_13_1244_2019
PubChem_Cell_line; CVCL_1638
Encyclopedic resources Wikidata; Q54937528
Gene expression databases GEO; GSM206531
GEO; GSM621905
GEO; GSM784709
GEO; GSM827278
GEO; GSM887499
GEO; GSM888581
GEO; GSM1024410
GEO; GSM1374813
GEO; GSM1670334
Polymorphism and mutation databases Cosmic; 1473126
Cosmic; 1509858
Cosmic; 2434104
LiGeA; CCLE_501
Progenetix; CVCL_1638
Proteomic databases PRIDE; PXD003198
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42