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Cellosaurus DU145 (CVCL_0105)

[Text version]
Cell line name DU145
Synonyms DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145
Accession CVCL_0105
Resource Identification Initiative To cite this cell line use: DU145 (RRID:CVCL_0105)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: JFCR39 cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Doubling time: 34 hours (Note=At 39th passage) (PubMed=631930); ~29 hours (ATCC=HTB-81); 28-38 hours (CLS=300168); ~30-40 hours (DSMZ=ACC-261); 32.3 hours (NCI-DTP=DU-145); ~29 hours (PBCF); 51.21 hours (JWGray panel).
Microsatellite instability: Instable (MSI-high) (PubMed=23671654; PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; GPI-anchored proteins.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Misspelling: DU145T; GEO=GSM843494.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
HLA typing Source: PubMed=15748285
Class I
HLA-AA*03:01:01,33:03
HLA-BB*50:01,57:01:01
HLA-CC*06:02
Class II
HLA-DPDPB1*04:01
HLA-DQDQB1*03:03:02,05:01:01

Source: PubMed=26589293
Class I
HLA-AA*33:03,33:03
HLA-BB*50:01,57:01
HLA-CC*06:02,06:02
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*01:01,01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.75
Native American0
East Asian, North2.66
East Asian, South0
South Asian0.04
European, North63.74
European, South32.8
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1968 (BM-1604)CVCL_4Y36 (DU-145 R)CVCL_J251 (DU-145-Luc)
CVCL_E6ZG (DU145 fat-1)CVCL_VE02 (DU145-AR)CVCL_A9CI (DU145-Cas9-539)
CVCL_A9CJ (DU145-Cas9-540)CVCL_A9CK (DU145-Cas9-541)CVCL_C0QR (DU145-R)
CVCL_ZX03 (DU145-TxR)CVCL_C9GA (DU145/Cas9-hyg)CVCL_AS75 (DU145/RC0.1)
CVCL_D639 (DU145/RC1)CVCL_E1JR (HyCyte DU145 KO-hLncRNA)CVCL_E3H5 (HyCyte DU145-Luc)
CVCL_4781 (ND-1)CVCL_4901 (SR DU-145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0019004/4984; ATCC=HTB-81; CCRID; CLS=300168; Cosmic-CLP=905935; COG; DSMZ=ACC-261; KCLB=30081; PubMed=11304728; PubMed=11416159; PubMed=14518029; PubMed=17254797; PubMed=19372543; PubMed=25877200; RCB=RCB2143; Technion Genomics Center; TKG=TKG 0604

Markers:
AmelogeninX,Y
CSF1PO10,11
D1S165614,15,16,17.3
D2S4419,13,14
D2S133816 (ATCC=HTB-81; CCRID; DSMZ=ACC-261)
16,17 (Technion Genomics Center)
D3S135816
D5S81810,13
D7S8207,10,11 (AddexBio=C0019004/4984; ATCC=HTB-81; CCRID; COG; Cosmic-CLP=905935; DSMZ=ACC-261; KCLB=30081; PubMed=11304728; PubMed=14518029; PubMed=17254797; PubMed=25877200; Technion Genomics Center)
7,10,11,12 (CLS=300168)
D8S117913,14
D10S124812,13
D12S39117,18,20,21
D13S31712,13,14 (AddexBio=C0019004/4984; ATCC=HTB-81; CCRID; CLS=300168; COG; DSMZ=ACC-261; PubMed=11304728; PubMed=14518029; PubMed=25877200; Technion Genomics Center)
12,14 (Cosmic-CLP=905935; KCLB=30081; PubMed=17254797; PubMed=19372543; RCB=RCB2143; TKG=TKG 0604)
D16S53911,12,13 (Technion Genomics Center)
11,13 (ATCC=HTB-81; CCRID; CLS=300168; COG; DSMZ=ACC-261; PubMed=25877200)
D18S5111,12 (PubMed=11304728; PubMed=14518029)
12 (ATCC=HTB-81; CCRID; DSMZ=ACC-261; PubMed=17254797; PubMed=19372543; PubMed=25877200)
12,13 (CLS=300168; Technion Genomics Center)
D19S43313 (ATCC=HTB-81; CCRID; DSMZ=ACC-261)
13,14 (Technion Genomics Center)
D21S1129,30 (PubMed=17254797)
29,30,33 (PubMed=11416159)
30,32,33,34 (PubMed=14518029; Technion Genomics Center)
30,33 (CCRID; DSMZ=ACC-261; PubMed=11304728; PubMed=19372543; PubMed=25877200)
30,33,34 (ATCC=HTB-81; CLS=300168)
D22S104516
DYS39110
FGA21,22 (DSMZ=ACC-261)
21,22,23 (ATCC=HTB-81)
22 (CCRID; PubMed=11304728; PubMed=14518029; PubMed=17254797; PubMed=25877200; Technion Genomics Center)
22,23 (CLS=300168)
Penta D9,13
Penta E12,14
TH017
TPOX11
vWA16,17,18 (PubMed=17254797)
17,18 (COG; DSMZ=ACC-261; KCLB=30081; PubMed=11304728; PubMed=14518029; PubMed=19372543; PubMed=25877200; TKG=TKG 0604)
17,18,19 (AddexBio=C0019004/4984; ATCC=HTB-81; CCRID; CLS=300168; Cosmic-CLP=905935; PubMed=11416159; RCB=RCB2143; Technion Genomics Center)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=54
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544441
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/d/cell-lines-detail-135.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/DU145
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/prostate-cancer-xenograft/du145-xenograft-model/
Publications

PubMed=631930; DOI=10.1002/ijc.2910210305
Kenneth R. Stone, Don D. Mickey, Heidi Wunderli-Allenspach, George H. Mickey, David F. Paulson;
Isolation of a human prostate carcinoma cell line (DU 145).
Int. J. Cancer 21:274-281(1978)

PubMed=6244232
Richard D. Williams;
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Marilyn S. Pollack, Socorro D. Heagney, Philip O. Livingston, Jorgen Fogh;
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=2744886; DOI=10.1002/ijc.2910440128
Beryl Hartley-Asp, Anita Billstrom, Elisabeth Kruse;
Identification by C-banding of two human prostate tumour cell lines, 1013L and DU 145.
Int. J. Cancer 44:161-164(1989)

PubMed=1873816
William B. Isaacs, Bob S. Carter, Charles M. Ewing;
Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.
Cancer Res. 51:4716-4720(1991)

PubMed=1574572; DOI=10.2307/3578273
Edward J. Dunphy, Michael A. Beckett, Lawrence H. Thompson, Ralph R. Weichselbaum;
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8104329; DOI=10.1002/pros.2990230206
Alan G. Carroll, H. James Voeller, LaVencia Sugars, Edward P. Gelmann;
p53 oncogene mutations in three human prostate cancer cell lines.
Prostate 23:123-134(1993)

PubMed=8510267; DOI=10.1016/S0022-5347(17)35458-7
Peter J. Effert, Rachael H. McCoy, Philip John Walther, Edison Tak-Bun Liu;
p53 gene alterations in human prostate carcinoma.
J. Urol. 150:257-261(1993)

PubMed=8612713; DOI=10.1006/excr.1996.0146
Elizabeth S. Woo, Yukihiro Kondo, Simon C. Watkins, Dale G. Hoyt, John Stephen Lazo;
Nucleophilic distribution of metallothionein in human tumor cells.
Exp. Cell Res. 224:365-371(1996)

PubMed=9018337; DOI=10.1002/(SICI)1097-0045(19970101)30:1<58::AID-PROS9>3.0.CO;2-H
Mukta M. Webber, Diana Bello, Salmaan T.A. Quader;
Immortalized and tumorigenic adult human prostatic epithelial cell lines: characteristics and applications Part 2. Tumorigenic cell lines.
Prostate 30:58-64(1997)

PubMed=9214606; DOI=10.1093/carcin/18.6.1225
Mukta M. Webber, Diana Bello, Hynda Karen Kleinman, Matthew P. Hoffman;
Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells.
Carcinogenesis 18:1225-1231(1997)

PubMed=9331090
Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy Gene Myers, Sai-Jun Fan, Masato Mutoh, Dominic A. Scudiero, Anne Monks, Edward A. Sausville, John N. Weinstein, Stephen H. Friend ...Show all 13 authors... , Albert J. Fornace Jr., Kurt W. Kohn; Show fewer authors
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer Res. 57:4285-4300(1997)

PubMed=9460501; DOI=10.1016/S0165-4608(97)00060-5
Nina N. Nupponen, Eija-Riitta Hyytinen, Anne H. Kallioniemi, Tapio Visakorpi;
Genetic alterations in prostate cancer cell lines detected by comparative genomic hybridization.
Cancer Genet. Cytogenet. 101:53-57(1998)

PubMed=10702678; DOI=10.1159/000015432
Yi Pan, Soili Kytola, Filip Farnebo, Na Wang, Weng-Onn Lui, Nina N. Nupponen, Jorma J. Isola, Tapio Visakorpi, Ulf S.R. Bergerheim, Catharina Larsson;
Characterization of chromosomal abnormalities in prostate cancer cell lines by spectral karyotyping.
Cytogenet. Cell Genet. 87:225-232(1999)

PubMed=10700174; DOI=10.1038/73432
Douglas T. Ross, Uwe Scherf, Michael Bruce Eisen, Charles M. Perou, Christian Rees, Paul T. Spellman, Vishwanath R. Iyer, Stefanie S. Jeffrey, Matt van de Rijn, Mark C. Waltham, Alexander Pergamenschikov ...Show all 18 authors... , Jeffrey C.F. Lee, Deval Lashkari, Dari Shalon, Timothy Gene Myers, John N. Weinstein, David Botstein, Patrick O'Reilly Brown; Show fewer authors
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H
Christine Rauh-Adelmann, Kin-Mang Lau, Nari Sabeti, John P. Long, Samuel C. Mok, Shuk-Mei Ho;
Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines.
Mol. Carcinog. 28:236-246(2000)

PubMed=11135431; DOI=10.1002/1098-2264(2000)9999:9999<::AID-GCC1076>3.0.CO;2-E
Joan Aurich-Costa, Anne Vannier, Eric Gregoire, Frederique Nowak, Dorra Cherif;
IPM-FISH, a new M-FISH approach using IRS-PCR painting probes: application to the analysis of seven human prostate cell lines.
Genes Chromosomes Cancer 30:143-160(2001)

PubMed=11172901; DOI=10.1016/S0165-4608(00)00339-3
Jonathan C. Strefford, Debra M. Lillington, Bryan D. Young, R. Timothy D. Oliver;
The use of multicolor fluorescence technologies in the characterization of prostate carcinoma cell lines: a comparison of multiplex fluorescence in situ hybridization and spectral karyotyping data.
Cancer Genet. Cytogenet. 124:112-121(2001)

PubMed=11280753
Yoshimasa Urasaki, Gary S. Laco, Phillipe Pourquier, Yuji Takebayashi, Glenda Kohlhagen, Christopher Gioffre, Hong-Liang Zhang, Devasis Chatterjee, Panayotis Pantazis, Yves Pommier;
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Cancer Res. 61:1964-1969(2001)

PubMed=11304728; DOI=10.1002/pros.1045
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller;
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12606952; DOI=10.1038/sj.onc.1206247
Jeremy Clark, Sandra Edwards, Andrew Feber, Penny Flohr, Megan John, Ian Giddings, Susan Crossland, Michael Rudolf Stratton, Richard Wooster, Colin Campbell, Colin S. Cooper;
Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays.
Oncogene 22:1247-1252(2003)

PubMed=12615715
William C. Reinhold, Hosein Kouros-Mehr, Kurt W. Kohn, Alika K. Maunakea, Samir Lababidi, Anna V. Roschke, Kristen Stover, Jes Alexander, Panayotis Pantazis, Lance D. Miller, Edison Tak-Bun Liu ...Show all 15 authors... , Ilan R. Kirsch, Yoshimasa Urasaki, Yves Pommier, John N. Weinstein; Show fewer authors
Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping.
Cancer Res. 63:1000-1011(2003)

PubMed=12725112; DOI=10.1385/1-59259-372-0:21
Pamela J. Russell, Elizabeth A. Kingsley;
Human prostate cancer cell lines.
Methods Mol. Med. 81:21-39(2003)

PubMed=14518029; DOI=10.1002/pros.10290
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Widya U. Johannes, E. Erin Smith, Heidi L. Miller, Steven K. Nordeen, Gary J. Miller, M. Scott Lucia;
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=15486987; DOI=10.1002/pros.20158
Hong-Juan Zhao, Young Kim, Pei Wang, Jacques Lapointe, Robert Tibshirani, Jonathan R. Pollack, James D. Brooks;
Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines.
Prostate 63:187-197(2005)

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L. Holbeck, Herbert Carpenter Morse 3rd, David Stroncek, Francesco M. Marincola;
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ogechi N. Ikediobi, Helen R. Davies, Graham Robert Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck ...Show all 49 authors... , Adam P. Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivian Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Martin Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip J. Stephens, Jon W. Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster; Show fewer authors
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=17440963; DOI=10.1002/pros.20581
Masashi Takeda, Atsushi Mizokami, Kiminori Mamiya, You-Qiang Li, Jian Zhang, Evan T. Keller, Mikio Namiki;
The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines.
Prostate 67:955-967(2007)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen Jacob Chanock, John N. Weinstein;
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Miguel Marino, Lisa J. Green, Meena I. Vora, Chirayu Patel, Josiah N. Orina, Tatiana A. Eliseeva, Vineet Singal, Raji Padmanabhan ...Show all 17 authors... , Ben Davidson, Ram Ganapathi, Anil K. Sood, Bo R. Rueda, Suresh V. Ambudkar, Michael Marc Gottesman; Show fewer authors
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=22275356; DOI=10.1074/jbc.M111.302547; PMCID=PMC3322861
Thomas P. Lynch, Christina M. Ferrer, S. RaElle Jackson, Kristina S. Shahriari, Keith Vosseller, Mauricio J. Reginato;
Critical role of O-linked beta-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.
J. Biol. Chem. 287:11070-11081(2012)

PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017
De-Xin Kong, Takao Yamori;
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Bioorg. Med. Chem. 20:1947-1951(2012)

PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Xiao-Yang Ruan, Jean-Pierre A. Kocher, Yves Pommier, Hong-Fang Liu, William C. Reinhold;
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:e31628.1-e31628.9(2012)

PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Jun-Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam-Young Kang, Shin Hui Ng, Chang No Yoon, Young-Tae Chang;
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:e32096.1-e32096.8(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L. Souza, Ran Kafri, Marc Wallace Kirschner, Clary B. Clish, Vamsi Krishna Mootha;
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030
Yu-Heng Lu, T. David Soong, Olivier Elemento;
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:e63056.1-e63056.10(2013)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Ogan Demir Abaan, Eric C. Polley, Sean R. Davis, Yue-Lin J. Zhu, Sven Bilke, Robert L. Walker, Marbin A. Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck ...Show all 15 authors... , Richard M. Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer; Show fewer authors
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Amin Moghaddas Gholami, Hannes Hahne, Zhi-Xiang Wu, Florian Johann Auer, Chen Meng, Mathias Wilhelm, Bernhard Kuster;
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)

PubMed=23957452; DOI=10.3109/01913123.2013.814739
Jacques Gilloteaux, Nkechinyere Eze, James M. Jamison, Karen McGuire, Jack L. Summers;
A rare, human prostate oncocyte cell originates from the prostatic carcinoma (DU145) cell line.
Ultrastruct. Pathol. 37:440-448(2013)

PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206
Sonia C. Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M. Tedeschi, Joseph Rocco Bertino, Kim Marie Hirshfield, Zoltan Nagy Oltvai, Alexei Vazquez;
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)

PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Sudhir Varma, Yves Pommier, Margot Sunshine, John N. Weinstein, William C. Reinhold;
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:e92047.1-e92047.15(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008
Yusuke Masuishi, Yayoi Kimura, Noriaki Arakawa, Hisashi Hirano;
Identification of glycosylphosphatidylinositol-anchored proteins and omega-sites using TiO2-based affinity purification followed by hydrogen fluoride treatment.
J. Proteomics 139:77-83(2016)

PubMed=27141528; DOI=10.1016/j.dib.2016.04.001; PMCID=PMC4838930
Yusuke Masuishi, Yayoi Kimura, Noriaki Arakawa, Hisashi Hirano;
Data for identification of GPI-anchored peptides and omega-sites in cancer cell lines.
Data Brief 7:1302-1305(2016)

PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
Pieter Mestdagh, Steve Lefever, Pieter-Jan Volders, Stefaan Derveaux, Jan Hellemans, Jo Vandesompele;
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052.1-160052.6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121
John G. Zampella, Nemanja Rodic, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby Charles Cornish, Jef D. Boeke, Kathleen H. Burns;
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30244336; DOI=10.1007/s00345-018-2501-6
Hale Samli, Murat Samli, Buse Vatansever, Sena Ardicli, Nazlihan Aztopal, Deniz Dincel, Ahmet Sahin, Faruk Balci;
Paclitaxel resistance and the role of miRNAs in prostate cancer cell lines.
World J. Urol. 37:1117-1126(2019)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30787054; DOI=10.1158/1055-9965.EPI-18-1132; PMCID=PMC6548687
Stanley Eugene Hooker Jr., Leanne Woods-Burnham, Madhavi Bathina, Stacy Lloyd, Priyatham Gorjala, Ranjana Mitra, Larisa Nonn, K. Sean Kimbro, Rick Antonius Kittles;
Genetic ancestry analysis reveals misclassification of commonly used cancer cell lines.
Cancer Epidemiol. Biomarkers Prev. 28:1003-1009(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194
Mark W. Kunkel, Nathan P. Coussens, Joel Morris, Ronald C. Taylor, Thomas S. Dexheimer, Eric M. Jones, James H. Doroshow, Beverly A. Teicher;
HTS384 NCI60: the next phase of the NCI60 screen.
Cancer Res. 84:2403-2416(2024)

PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770
Erica L. Beatson, Emily N. Risdon, Giulia C. Napoli, Douglas K. Price, Cindy H. Chau, William Douglas Figg Sr.;
Genomic characterization of preclinical prostate cancer cell line models.
Int. J. Mol. Sci. 25:6111.1-6111.19(2024)

Cross-references
Cell line collections (Providers) AddexBio; C0019004/4984
ATCC; HTB-81
BCRC; 60348
BCRJ; 0078
CLS; 300168
DSMZ; ACC-261
ICLC; HTL99013
IZSLER; BS TCL 141
KCB; KCB 200701YJ
KCLB; 30081
NCBI_Iran; C428
NCI-DTP; DU-145
RCB; RCB2143
TKG; TKG 0604
Cell line databases/resources CLO; CLO_0002840
CLO; CLO_0051536
MCCL; MCC:0000140
CLDB; cl1108
CLDB; cl1109
CLDB; cl4961
CLDB; cl5184
cancercelllines; CVCL_0105
CCRID; 1101HUM-PUMC000006
CCRID; 3101HUMSCSP5024
CCRID; 3101HUMTCHu222
Cell_Model_Passport; SIDM00120
Cosmic-CLP; 905935
DepMap; ACH-000979
DSMZCellDive; ACC-261
LINCS_LDP; LCL-1146
Lonza; 761
SKY/M-FISH/CGH; 2792
TOKU-E; 1103
Anatomy/cell type resources BTO; BTO_0001332
Biological sample resources BioSample; SAMN03472017
BioSample; SAMN03472041
BioSample; SAMN03472757
BioSample; SAMN05292468
BioSample; SAMN10988253
ENCODE; ENCBS077VSE
ENCODE; ENCBS721QHV
CRISP screens repositories BioGRID_ORCS_Cell_line; 860
Chemistry resources ChEMBL-Cells; CHEMBL3308034
ChEMBL-Targets; CHEMBL613508
GDSC; 905935
PharmacoDB; DU145_309_2019
PubChem_Cell_line; CVCL_0105
Encyclopedic resources Wikidata; Q5206280
Experimental variables resources EFO; EFO_0005441
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10490-107B4
GEO; GSM2120
GEO; GSM50224
GEO; GSM50288
GEO; GSM91924
GEO; GSM142455
GEO; GSM142456
GEO; GSM482671
GEO; GSM525794
GEO; GSM648818
GEO; GSM648819
GEO; GSM743479
GEO; GSM750774
GEO; GSM750834
GEO; GSM784791
GEO; GSM799369
GEO; GSM799379
GEO; GSM799432
GEO; GSM799442
GEO; GSM843494
GEO; GSM886988
GEO; GSM888057
GEO; GSM1153440
GEO; GSM1153441
GEO; GSM1181273
GEO; GSM1181302
GEO; GSM1181306
GEO; GSM1181328
GEO; GSM1374469
GEO; GSM1374470
GEO; GSM1669745
GEO; GSM2124639
Polymorphism and mutation databases Cosmic; 688116
Cosmic; 699306
Cosmic; 704850
Cosmic; 721367
Cosmic; 721558
Cosmic; 755299
Cosmic; 759893
Cosmic; 801349
Cosmic; 809223
Cosmic; 809224
Cosmic; 850415
Cosmic; 850824
Cosmic; 869156
Cosmic; 875891
Cosmic; 876395
Cosmic; 897454
Cosmic; 905935
Cosmic; 911998
Cosmic; 918501
Cosmic; 921050
Cosmic; 922550
Cosmic; 923401
Cosmic; 923956
Cosmic; 943177
Cosmic; 948075
Cosmic; 949247
Cosmic; 974300
Cosmic; 1028649
Cosmic; 1028700
Cosmic; 1057758
Cosmic; 1070887
Cosmic; 1071478
Cosmic; 1071905
Cosmic; 1075274
Cosmic; 1092597
Cosmic; 1172627
Cosmic; 1175887
Cosmic; 1176617
Cosmic; 1212490
Cosmic; 1218869
Cosmic; 1305381
Cosmic; 1312368
Cosmic; 1330912
Cosmic; 1436047
Cosmic; 1481419
Cosmic; 1542078
Cosmic; 1689715
Cosmic; 1712065
Cosmic; 1995389
Cosmic; 1998439
Cosmic; 2580127
Cosmic; 2585152
Cosmic; 2585229
Cosmic; 2592487
Cosmic; 2651768
Cosmic; 2669167
Cosmic; 2674179
Cosmic; 2816220
IARC_TP53; 751
LiGeA; CCLE_356
Progenetix; CVCL_0105
Proteomic databases PRIDE; PXD003105
PRIDE; PXD005942
PRIDE; PXD005946
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number51