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Cellosaurus DU145-AR (CVCL_VE02)

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Cell line name DU145-AR
Synonyms DU-AR
Accession CVCL_VE02
Resource Identification Initiative To cite this cell line use: DU145-AR (RRID:CVCL_VE02)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:644; AR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=14649544; DOI=10.3727/000000003108748658
Eugenia Scaccianoce, Claudio Festuccia, Donatella Dondi, Vittoria Guerini, Mauro Bologna, Marcella Motta, Angelo Poletti;
Characterization of prostate cancer DU145 cells expressing the recombinant androgen receptor.
Oncol. Res. 14:101-112(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VE02
Encyclopedic resources Wikidata; Q54831574
Entry history
Entry creation14-May-2018
Last entry update14-Aug-2025
Version number14