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Cellosaurus DU145-Cas9-540 (CVCL_A9CJ)

[Text version]
Cell line name DU145-Cas9-540
Accession CVCL_A9CJ
Resource Identification Initiative To cite this cell line use: DU145-Cas9-540 (RRID:CVCL_A9CJ)
Comments Population: Caucasian.
Characteristics: Transduced with a Cas9-FLAG-Neo construct.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9 (Note=With a C-terminal FLAG tag).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): CCRID=1101HUM-PUMC000540

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133816
D3S135816
D5S81810,13
D6S104311
D7S8207,10,11
D8S117913,14
D12S39118,20
D13S31712,14
D16S53911
D18S5112
D19S43313
D21S1131,32,33
FGA22
Penta E12
TH017
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_A9CJ
CCRID; 1101HUM-PUMC000540
Encyclopedic resources Wikidata; Q108820169
Entry history
Entry creation23-Sep-2021
Last entry update14-Aug-2025
Version number11