| Cell line name |
ND-1 |
| Synonyms |
ND1 |
| Accession |
CVCL_4781 |
| Resource Identification Initiative |
To cite this cell line use: ND-1 (RRID:CVCL_4781) |
| Comments |
Problematic cell line: Contaminated. Shown to be a DU145 derivative (PubMed=11304728; PubMed=20143388; CelloPub=CLPUB00698). Originally thought to originate from a patient of unknown age with a primary prostate adenocarcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00244. Population: Caucasian. Derived from site: Metastatic; Brain; UBERON=UBERON_0000955. |
| Sequence variations |
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (PubMed=11304728).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (PubMed=11304728).
|
| Disease |
Prostate carcinoma (NCIt: C4863) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0105 (DU145) |
| Sex of cell |
Male |
| Age at sampling |
69Y |
| Category |
Cancer cell line |
| STR profile |
Source(s): PubMed=11304728
Markers: Run an STR similarity search on this cell line |
| Web pages |
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx |
| Publications | PubMed=1279221; DOI=10.1016/S0022-5347(17)36978-1 Priyanka Narayan, Raivir Dahiya; Establishment and characterization of a human primary prostatic adenocarcinoma cell line (ND-1). J. Urol. 148:1600-1604(1992) PubMed=11304728; DOI=10.1002/pros.1045 Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller; Widely used prostate carcinoma cell lines share common origins. Prostate 47:36-51(2001) CLPUB00698 Adrie van Bokhoven; Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines. Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands PubMed=20143388; DOI=10.1002/ijc.25242 Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney; Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010) |
| Cross-references |
| Cell line databases/resources |
cancercelllines; CVCL_4781
|
| Anatomy/cell type resources |
BTO; BTO_0001052
|
| Biological sample resources |
BioSample; SAMN03151638
|
| Encyclopedic resources |
Wikidata; Q54908299
|
| Entry history |
| Entry creation | 04-Apr-2012 |
| Last entry update | 10-Apr-2025 |
| Version number | 29 |
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