| Cell line name |
DU145-TxR |
| Accession |
CVCL_ZX03 |
| Resource Identification Initiative |
To cite this cell line use: DU145-TxR (RRID:CVCL_ZX03) |
| Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol). Omics: Transcriptomics; Microarray. Derived from site: Metastatic; Brain; UBERON=UBERON_0000955. |
| Sequence variations |
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
|
| Disease |
Prostate carcinoma (NCIt: C4863) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_0105 (DU145) Children:
|
| Sex of cell |
Male |
| Age at sampling |
69Y |
| Category |
Cancer cell line |
| Publications | PubMed=17440963; DOI=10.1002/pros.20581 Masashi Takeda, Atsushi Mizokami, Kiminori Mamiya, You-Qiang Li, Jian Zhang, Evan T. Keller, Mikio Namiki; The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines. Prostate 67:955-967(2007) PubMed=29662635; DOI=10.18632/oncotarget.24609; PMCID=PMC5882326 Kazuaki Machioka, Kouji Izumi, Yoshifumi Kadono, Hiroaki Iwamoto, Renato Naito, Tomoyuki Makino, Suguru Kadomoto, Ariunbold Natsagdorj, Evan T. Keller, Jian Zhang, Atsushi Mizokami; Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines. Oncotarget 9:16185-16196(2018) |
| Cross-references |
| Cell line databases/resources |
cancercelllines; CVCL_ZX03
|
| Encyclopedic resources |
Wikidata; Q102113777
|
| Entry history |
| Entry creation | 29-Oct-2020 |
| Last entry update | 10-Apr-2025 |
| Version number | 9 |
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