| Cell line name |
DU145-TxR/CxR |
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| Accession |
CVCL_ZX04 |
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| Resource Identification Initiative |
To cite this cell line use: DU145-TxR/CxR (RRID:CVCL_ZX04) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_63584; Cabazitaxel.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_ZX03 (DU145-TxR) |
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| Sex of cell |
Male |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=29662635; DOI=10.18632/oncotarget.24609; PMCID=PMC5882326
Kazuaki Machioka, Kouji Izumi, Yoshifumi Kadono, Hiroaki Iwamoto, Renato Naito, Tomoyuki Makino, Suguru Kadomoto, Ariunbold Natsagdorj, Evan T. Keller, Jian Zhang, Atsushi Mizokami;
Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines.
Oncotarget 9:16185-16196(2018) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_ZX04
|
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| Encyclopedic resources |
Wikidata; Q102113779
|
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| Entry history |
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| Entry creation | 29-Oct-2020 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 8 |
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