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Cellosaurus BM-1604 (CVCL_1968)

[Text version]
Cell line name BM-1604
Synonyms BM 1604; BM1604
Accession CVCL_1968
Resource Identification Initiative To cite this cell line use: BM-1604 (RRID:CVCL_1968)
Comments Problematic cell line: Contaminated. Shown to be a DU145 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 67 year old man with a primary prostatic adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00113.
Population: Caucasian.
Doubling time: 28 hours (PubMed=8054265); ~60 hours (Note=Highly variable) (DSMZ=ACC-298).
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-298; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133816
D3S135815,16
D5S81810,14
D7S8207,10
D8S117913,14
D13S31712,14
D16S53911,13
D18S5112
D19S43312,13
D21S1130,33,34
FGA22
Penta D9,13
Penta E12,14
TH017
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; CaP CLDb; -; https://web.archive.org/web/20160703200713/http://capcelllines.ca:80/details.asp?id=71
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=8054265; DOI=10.1038/bjc.1994.279; PMCID=PMC2033493
Paul D. van Helden, Ian J.F. Wiid, Eileen Garner Hoal-van Helden, Elke M. Bey, Ronald Joseph Cohen;
Detection by DNA fingerprinting of somatic changes during the establishment of a new prostate cell line.
Br. J. Cancer 70:195-198(1994)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
Roderick A.F. MacLeod, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Maren Kaufmann, Herbert Milch, Hans Gunther Drexler;
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) DSMZ; ACC-298 - Discontinued
Cell line databases/resources CLO; CLO_0002001
cancercelllines; CVCL_1968
DSMZCellDive; ACC-298
IGRhCellID; BM1604
Anatomy/cell type resources BTO; BTO_0002015
Biological sample resources BioSample; SAMN03151637
BioSample; SAMN03470924
Encyclopedic resources Wikidata; Q54797440
Experimental variables resources EFO; EFO_0002117
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Progenetix; CVCL_1968
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number31