ID   BM-1604
AC   CVCL_1968
SY   BM 1604; BM1604
DR   BTO; BTO_0002015
DR   CLO; CLO_0002001
DR   EFO; EFO_0002117
DR   ArrayExpress; E-MTAB-38
DR   BioSample; SAMN03151637
DR   BioSample; SAMN03470924
DR   cancercelllines; CVCL_1968
DR   DSMZ; ACC-298
DR   DSMZCellDive; ACC-298
DR   IGRhCellID; BM1604
DR   Progenetix; CVCL_1968
DR   Wikidata; Q54797440
RX   PubMed=8054265;
RX   PubMed=10508494;
RX   PubMed=20143388;
RX   PubMed=20215515;
RX   PubMed=25877200;
WW   Info; CaP CLDb; -; https://web.archive.org/web/20160703200713/http://capcelllines.ca:80/details.asp?id=71
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a DU145 derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a 67 year old man with a primary prostatic adenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00113.
CC   Population: Caucasian.
CC   Doubling time: 28 hours (PubMed=8054265); ~60 hours (Note=Highly variable) (DSMZ=ACC-298).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: DSMZ; ACC-298; true.
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
ST   Source(s): DSMZ=ACC-298; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 12,14
ST   D16S539: 11,13
ST   D18S51: 12
ST   D19S433: 12,13
ST   D21S11: 30,33,34
ST   D2S1338: 16
ST   D3S1358: 15,16
ST   D5S818: 10,14
ST   D7S820: 7,10
ST   D8S1179: 13,14
ST   FGA: 22
ST   Penta D: 9,13
ST   Penta E: 12,14
ST   TH01: 7
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0105 ! DU145
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod, Roderick A.F.
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   Kaufmann, Maren
RA   Milch, Herbert
RA   Drexler, Hans Gunther
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
//
RX   PubMed=8054265; DOI=10.1038/bjc.1994.279; PMCID=PMC2033493;
RA   van Helden, Paul D.
RA   Wiid, Ian J.F.
RA   Hoal-van Helden, Eileen Garner
RA   Bey, Elke M.
RA   Cohen, Ronald Joseph
RT   "Detection by DNA fingerprinting of somatic changes during the
RT   establishment of a new prostate cell line.";
RL   Br. J. Cancer 70:195-198(1994).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//