Cellosaurus SK-HEP-1 (CVCL_0525)
Cell line name | SK-HEP-1 | ||||||||||||||||||||||||||||||||||||||||
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Synonyms | SK-Hep-1; SK HEP-1; SK HEP 01; SK-Hep1; Sk-Hep1; SK Hep 1; SK Hep1; SKHEP-1; SKHEP1; SKHep1; SK_HEP1 | ||||||||||||||||||||||||||||||||||||||||
Accession | CVCL_0525 | ||||||||||||||||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: SK-HEP-1 (RRID:CVCL_0525) | ||||||||||||||||||||||||||||||||||||||||
Comments | Problematic cell line: Misclassified. Originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells (PubMed=1371504; PubMed=31938418). Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: MD Anderson Cell Lines Project. From: Memorial Sloan Kettering Cancer Center; New York; USA. Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-535. Population: Caucasian. Doubling time: 46.7 +- 10.3 hours, 94.2 hours (Note=In CDM4-CHO medium), 289.8 hours (Note=In 293 SFM II medium) (PubMed=25822314); ~30 hours (DSMZ=ACC-141). Karyotypic information: Has lost chromosome Y. Microsatellite instability: Stable (MSS) (Sanger). Omics: Genomics; DNA methylation analysis. Omics: Genomics; Whole exome sequencing. Omics: Phenotyping; Drug screening. Omics: Proteomics; Expression; Reverse-phase protein array. Omics: Proteomics; Quantitative. Omics: Proteomics; Subcellular; Secretome. Omics: Transcriptomics; Microarray. Omics: Transcriptomics; RNAseq. Omics: Variations; SNP array analysis. Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. Cell type: Endothelial cell; CL=CL_0000115. | ||||||||||||||||||||||||||||||||||||||||
Sequence variations |
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HLA typing | Source: PubMed=9178645
Source: PubMed=26589293
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Genome ancestry | Source: PubMed=30894373
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Disease | Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106) | ||||||||||||||||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | ||||||||||||||||||||||||||||||||||||||||
Hierarchy | Children:
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Sex of cell | Male | ||||||||||||||||||||||||||||||||||||||||
Age at sampling | 52Y | ||||||||||||||||||||||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||||||||||||||||||||||
STR profile | Source(s): ATCC=HTB-52; CCRID; CLS=300334; Cosmic-CLP=909719; DSMZ=ACC-141; ECACC=91091816; KCLB=30052; MSKCC; PubMed=11416159; PubMed=25877200 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||||||||||||||||||||||
Web pages | Info; MCLP; -; https://tcpaportal.org/mclp/ Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-397.html Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/liver-cancer-xenograft/sk-hep1-xenograft-model/ Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-hep-1-human-hepatic-adenocarcinoma-cell-line | ||||||||||||||||||||||||||||||||||||||||
Publications | DOI=10.1007/978-1-4757-1647-4_5 PubMed=327080; DOI=10.1093/jnci/59.1.221 PubMed=833871; DOI=10.1093/jnci/58.2.209 PubMed=924690; DOI=10.1002/ijc.2910200505 PubMed=6935474; DOI=10.1093/jnci/66.2.239 PubMed=7017212; DOI=10.1093/jnci/66.6.1003 PubMed=7459858 PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720 PubMed=3518877; DOI=10.3109/07357908609038260 PubMed=2439335; DOI=10.1111/j.1432-1033.1987.tb11497.x PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0 PubMed=1371504; DOI=10.1007/BF02631017 PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613 PubMed=8389256; DOI=10.1093/carcin/14.5.987 PubMed=9023415; DOI=10.1006/cimm.1996.1062 PubMed=9178645; DOI=10.1006/cimm.1997.1108 PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459 PubMed=12029633; DOI=10.1053/jhep.2002.33683 PubMed=12068308; DOI=10.1038/nature00766 PubMed=20069059; DOI=10.1155/2010/437143; PMCID=PMC2801507 PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113 PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027 PubMed=23505090; DOI=10.1002/hep.26402 PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665 PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350 PubMed=25822314; DOI=10.1007/s00449-015-1392-9 PubMed=25877200; DOI=10.1038/nature14397 PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469 PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076 PubMed=31938418; PMCID=PMC6958242 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675 PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103 PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254 PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775 | ||||||||||||||||||||||||||||||||||||||||
Cross-references | |||||||||||||||||||||||||||||||||||||||||
Cell line collections (Providers) | ATCC; HTB-52
CancerTools; 161934 CCTCC; GDC0145 CLS; 300334 DSMZ; ACC-141 ECACC; 91091816 ICLC; HTL10001 KCB; KCB 2013038YJ KCLB; 30052 Ubigene; YC-C007 | ||||||||||||||||||||||||||||||||||||||||
Cell line databases/resources | CLO; CLO_0009037
MCCL; MCC:0000425 CLDB; cl4312 CLDB; cl4313 CLDB; cl4314 CLDB; cl4315 CLDB; cl7214 cancercelllines; CVCL_0525 CCRID; 1101HUM-PUMC000677 CCRID; 1102HUM-NIFDC00060 CCRID; 3101HUMTCHu109 CCRID; 4201HUM-CCTCC00145 Cell_Model_Passport; SIDM01110 CGH-DB; 9071-4 Cosmic-CLP; 909719 DepMap; ACH-000361 DSMZCellDive; ACC-141 FCS-free; 174-2-331-1-4-3 LINCS_LDP; LCL-1941 TOKU-E; 3132 | ||||||||||||||||||||||||||||||||||||||||
Anatomy/cell type resources | BTO; BTO_0003477 | ||||||||||||||||||||||||||||||||||||||||
Biological sample resources | BioSample; SAMN01821598
BioSample; SAMN01821664 BioSample; SAMN03472884 BioSample; SAMN10988022 | ||||||||||||||||||||||||||||||||||||||||
CRISP screens repositories | BioGRID_ORCS_Cell_line; 467 | ||||||||||||||||||||||||||||||||||||||||
Chemistry resources | ChEMBL-Cells; CHEMBL3307741
ChEMBL-Targets; CHEMBL614912 GDSC; 909719 PharmacoDB; SKHEP1_1390_2019 PubChem_Cell_line; CVCL_0525 | ||||||||||||||||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54953666 | ||||||||||||||||||||||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770 ArrayExpress; E-MTAB-3610 GEO; GSM481451 GEO; GSM501784 GEO; GSM565878 GEO; GSM887578 GEO; GSM888661 GEO; GSM936776 GEO; GSM1374879 GEO; GSM1670432 GEO; GSM2551582 | ||||||||||||||||||||||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 684195
Cosmic; 735607 Cosmic; 873394 Cosmic; 909719 Cosmic; 928139 Cosmic; 932990 Cosmic; 979728 Cosmic; 1187333 Cosmic; 1518231 Cosmic; 2162539 Cosmic; 2321042 Cosmic; 2668284 IARC_TP53; 27577 LiGeA; CCLE_110 Progenetix; CVCL_0525 | ||||||||||||||||||||||||||||||||||||||||
Proteomic databases | PRIDE; PXD002957
PRIDE; PXD030304 | ||||||||||||||||||||||||||||||||||||||||
Sequence databases | EGA; EGAS00001000978 | ||||||||||||||||||||||||||||||||||||||||
Entry history | |||||||||||||||||||||||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||||||||||||||||||||||
Last entry update | 10-Apr-2025 | ||||||||||||||||||||||||||||||||||||||||
Version number | 46 |