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Cellosaurus SK-HEP-1 (CVCL_0525)

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Cell line name SK-HEP-1
Synonyms SK-Hep-1; SK HEP-1; SK HEP 01; SK-Hep1; Sk-Hep1; SK Hep 1; SK Hep1; SKHEP-1; SKHEP1; SKHep1; SK_HEP1
Accession CVCL_0525
Resource Identification Initiative To cite this cell line use: SK-HEP-1 (RRID:CVCL_0525)
Comments Problematic cell line: Misclassified. Originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells (PubMed=1371504; PubMed=31938418).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK1980-535.
Population: Caucasian.
Doubling time: 46.7 +- 10.3 hours, 94.2 hours (Note=In CDM4-CHO medium), 289.8 hours (Note=In 293 SFM II medium) (PubMed=25822314); ~30 hours (DSMZ=ACC-141).
Karyotypic information: Has lost chromosome Y.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Secretome.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Cell type: Endothelial cell; CL=CL_0000115.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (ATCC=HTB-52).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=12068308; ATCC=HTB-52; Cosmic-CLP=909719; DepMap=ACH-000361).
HLA typing Source: PubMed=9178645
Class I
HLA-AA*02:01,24:02
HLA-BB*35:04,44:03:01
HLA-CC*04:01
Class II
HLA-DQDQA1*01:02
DQB1*05:02,06.04
HLA-DRDRB1*13:02,16:02

Source: PubMed=26589293
Class I
HLA-AA*02:01,24:02
HLA-BB*35:02,44:03
HLA-CC*04:01,04:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.65
Native American1.18
East Asian, North0
East Asian, South2.22
South Asian8.09
European, North23.66
European, South64.2
Disease Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E7C3 (Abcam SK-HEP-1 S1PR1 KO)CVCL_A040 (F2.4E5)CVCL_A041 (F2.5B6)
CVCL_E1MT (HyCyte SK-HEP-1 KO-hHSP90AA1)CVCL_E1MU (HyCyte SK-HEP-1 KO-hMGST1)CVCL_E1MV (HyCyte SK-HEP-1 KO-hPFDN2)
CVCL_A042 (P1.1A3)CVCL_A046 (P1.4D6)CVCL_XD84 (SK-HEP-1-Cas9-726)
CVCL_XD85 (SK-HEP-1-Cas9-727)CVCL_XD86 (SK-HEP-1-Cas9-728)CVCL_XD87 (SK-HEP-1-Cas9-729)
CVCL_XD88 (SK-HEP-1-Cas9-730)CVCL_XD89 (SK-HEP-1-Cas9-731)CVCL_XD90 (SK-HEP-1-Cas9-732)
CVCL_XD91 (SK-HEP-1-Cas9-733)CVCL_XD92 (SK-HEP-1-Cas9-734)CVCL_XD93 (SK-HEP-1-Cas9-735)
CVCL_AU01 (SK-HEP-1-FIX)CVCL_C8XK (SK-HEP-1-Luc)CVCL_6019 (SK-Hep-1-NIS)
CVCL_C9DI (SK-HEP-1/Cas9-hyg)CVCL_M182 (SK-Hep-1/CDDP)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-52; CCRID; CLS=300334; Cosmic-CLP=909719; DSMZ=ACC-141; ECACC=91091816; KCLB=30052; MSKCC; PubMed=11416159; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133820,23
D3S135816
D5S81810,13
D6S104311
D7S8208,11
D8S117913,14
D12S39118
D13S3178,12
D16S53912
D18S5113,15
D19S43312 (DSMZ=ACC-141)
12,15.2 (ATCC=HTB-52; CCRID; CLS=300334; MSKCC; PubMed=25877200)
D21S1129,31
FGA17
Penta D13,14
Penta E13 (PubMed=25877200)
13,21 (ATCC=HTB-52; CCRID; CLS=300334; DSMZ=ACC-141)
TH017,9
TPOX9
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-397.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/liver-cancer-xenograft/sk-hep1-xenograft-model/
Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-hep-1-human-hepatic-adenocarcinoma-cell-line
Publications

DOI=10.1007/978-1-4757-1647-4_5
Jorgen Fogh, Germain L. Trempe;
New human tumor cell lines.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.115-159; Springer; New York; USA (1975)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=924690; DOI=10.1002/ijc.2910200505
Robert S. Kerbel, Hugh F. Pross, Albert Leibovitz;
Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.
Int. J. Cancer 20:673-679(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Marilyn S. Pollack, Socorro D. Heagney, Philip O. Livingston, Jorgen Fogh;
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2439335; DOI=10.1111/j.1432-1033.1987.tb11497.x
Claude Vincent, Marianne Marceau, Pascale Blangarin, Patrick Bouic, Jean-Jacques Madjar, Jean-Pierre Revillard;
Purification of alpha 1-microglobulin produced by human hepatoma cell lines. Biochemical characterization and comparison with alpha 1-microglobulin synthesized by human hepatocytes.
Eur. J. Biochem. 165:699-704(1987)

PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0
Gretchen J. Darlington;
Liver cell lines.
Methods Enzymol. 151:19-38(1987)

PubMed=1371504; DOI=10.1007/BF02631017
Sue C. Heffelfinger, Hal H. Hawkins, Jim Barrish, Linda Taylor, Gretchen J. Darlington;
SK HEP-1: a human cell line of endothelial origin.
In Vitro Cell. Dev. Biol. Anim. 28:136-142(1992)

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613
Alain Puisieux, Katherine Galvin, Frederic Troalen, Brigitte Bressac, Christophe Marcais, Eithan Galun, Frederique Ponchel, Cengiz Yakicier, Jing-Wei Ji, Mehmet Ozturk;
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB J. 7:1407-1413(1993)

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Ih-Chang Hsu, Takayoshi Tokiwa, William P. Bennett, Robert A. Metcalf, Judith A. Welsh, Tsung-Tang Sun, Curtis Craig Harris;
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Masanobu Nakao, Michio Sata, Hideki Saitsu, Shigeru Yutani, Mayumi Kawamoto, Masamichi Kojiro, Kyogo Itoh;
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12029633; DOI=10.1053/jhep.2002.33683
Kohichiroh Yasui, Shigeki Arii, Chen Zhao, Issei Imoto, Masakazu Ueda, Hisaki Nagai, Mitsuru Emi, Johji Inazawa;
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Hepatology 35:1476-1484(2002)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20069059; DOI=10.1155/2010/437143; PMCID=PMC2801507
Chantragan Srisomsap, Phannee Sawangareetrakul, Pantipa Subhasitanont, Daranee Chokchaichamnankit, Khajeelak Chiablaem, Vajarabhongsa Bhudhisawasdi, Sopit Wongkham, Jisnuson Svasti;
Proteomic studies of cholangiocarcinoma and hepatocellular carcinoma cell secretomes.
J. Biomed. Biotechnol. 2010:437143.1-437143.18(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23505090; DOI=10.1002/hep.26402
Kai Wang, Ho Yeong Lim, Stephanie Shi, Jeeyun Lee, Shi-Bing Deng, Tao Xie, Zhou Zhu, Yu-Li Wang, David Pocalyko, Wei Jennifer Yang, Paul A. Rejto ...Show all 14 authors... , Mao Mao, Cheol-Keun Park, Jiang-Chun Xu; Show fewer authors
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Jean-Charles Nault, Maxime Mallet, Camilla Pilati, Julien Calderaro, Paulette Bioulac-Sage, Christophe Laurent, Alexis Laurent, Daniel Cherqui, Charles Balabaud, Jessica Zucman-Rossi;
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350
Dilek Cevik, Gokhan Yildiz, Mehmet Ozturk;
Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.
World J. Gastroenterol. 21:311-317(2015)

PubMed=25822314; DOI=10.1007/s00449-015-1392-9
Rafael Tage Biaggio, Mario Soares de Abreu-Neto, Dimas Tadeu Covas, Kamilla Swiech;
Serum-free suspension culturing of human cells: adaptation, growth, and cryopreservation.
Bioprocess Biosyst. Eng. 38:1495-1507(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=31938418; PMCID=PMC6958242
Yang Tai, Jing-Hui Gao, Chong Zhao, Huan Tong, Shu-Ping Zheng, Zhi-Yin Huang, Rui Liu, Cheng-Wei Tang, Jing Li;
SK-Hep1: not hepatocellular carcinoma cells but a cell model for liver sinusoidal endothelial cells.
Int. J. Clin. Exp. Pathol. 11:2931-2938(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-52
CancerTools; 161934
CCTCC; GDC0145
CLS; 300334
DSMZ; ACC-141
ECACC; 91091816
ICLC; HTL10001
KCB; KCB 2013038YJ
KCLB; 30052
Ubigene; YC-C007
Cell line databases/resources CLO; CLO_0009037
MCCL; MCC:0000425
CLDB; cl4312
CLDB; cl4313
CLDB; cl4314
CLDB; cl4315
CLDB; cl7214
cancercelllines; CVCL_0525
CCRID; 1101HUM-PUMC000677
CCRID; 1102HUM-NIFDC00060
CCRID; 3101HUMTCHu109
CCRID; 4201HUM-CCTCC00145
Cell_Model_Passport; SIDM01110
CGH-DB; 9071-4
Cosmic-CLP; 909719
DepMap; ACH-000361
DSMZCellDive; ACC-141
FCS-free; 174-2-331-1-4-3
LINCS_LDP; LCL-1941
TOKU-E; 3132
Anatomy/cell type resources BTO; BTO_0003477
Biological sample resources BioSample; SAMN01821598
BioSample; SAMN01821664
BioSample; SAMN03472884
BioSample; SAMN10988022
CRISP screens repositories BioGRID_ORCS_Cell_line; 467
Chemistry resources ChEMBL-Cells; CHEMBL3307741
ChEMBL-Targets; CHEMBL614912
GDSC; 909719
PharmacoDB; SKHEP1_1390_2019
PubChem_Cell_line; CVCL_0525
Encyclopedic resources Wikidata; Q54953666
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM481451
GEO; GSM501784
GEO; GSM565878
GEO; GSM887578
GEO; GSM888661
GEO; GSM936776
GEO; GSM1374879
GEO; GSM1670432
GEO; GSM2551582
Polymorphism and mutation databases Cosmic; 684195
Cosmic; 735607
Cosmic; 873394
Cosmic; 909719
Cosmic; 928139
Cosmic; 932990
Cosmic; 979728
Cosmic; 1187333
Cosmic; 1518231
Cosmic; 2162539
Cosmic; 2321042
Cosmic; 2668284
IARC_TP53; 27577
LiGeA; CCLE_110
Progenetix; CVCL_0525
Proteomic databases PRIDE; PXD002957
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number46