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Cellosaurus F2.4E5 (CVCL_A040)

[Text version]
Cell line name F2.4E5
Synonyms F2-4E5
Accession CVCL_A040
Resource Identification Initiative To cite this cell line use: F2.4E5 (RRID:CVCL_A040)
Comments Problematic cell line: Contaminated. Shown to be a SK-HEP-1 derivative (PubMed=10508494; PubMed=20143388). Originally thought to be a thymic epithelial cell line from a 9 week old fetal thymus.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00120.
Population: Caucasian.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Cell type: Endothelial cell; CL=CL_0000115.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0525 (SK-HEP-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=7514905; DOI=10.1182/blood.V83.11.3245.3245
Edgar Fernandez, Angeles Vicente, Agustin Zapata, Begona Brera, Juan J. Lozano, Carlos Martinez-Alonso, Maria Luisa Toribio;
Establishment and characterization of cloned human thymic epithelial cell lines. Analysis of adhesion molecule expression and cytokine production.
Blood 83:3245-3254(1994)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
Roderick A.F. MacLeod, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Maren Kaufmann, Herbert Milch, Hans Gunther Drexler;
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A040
Biological sample resources BioSample; SAMN03151917
Encyclopedic resources Wikidata; Q54833084
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number24