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Cellosaurus SK-Hep-1-NIS (CVCL_6019)

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Cell line name SK-Hep-1-NIS
Synonyms SK-Hep1-NIS
Accession CVCL_6019
Resource Identification Initiative To cite this cell line use: SK-Hep-1-NIS (RRID:CVCL_6019)
Comments Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
Population: Caucasian.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11040; SLC5A5.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Cell type: Endothelial cell; CL=CL_0000115.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0525 (SK-HEP-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=15347726
Joo Hyun Kang, June-Key Chung, Yong Jin Lee, Jae Hoon Shin, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee;
Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy.
J. Nucl. Med. 45:1571-1576(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6019
Encyclopedic resources Wikidata; Q54953669
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number24