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Cellosaurus SK-HEP-1-FIX (CVCL_AU01)

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Cell line name SK-HEP-1-FIX
Synonyms SK-Hep-1-FIX
Accession CVCL_AU01
Resource Identification Initiative To cite this cell line use: SK-HEP-1-FIX (RRID:CVCL_AU01)
Comments Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
Population: Caucasian.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3551; F9.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Cell type: Endothelial cell; CL=CL_0000115.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
Disease Liver and intrahepatic bile duct epithelial neoplasm (NCIt: C7106)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0525 (SK-HEP-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Publications

PubMed=26802680; DOI=10.1016/j.pep.2015.11.023
Aline de Sousa Bomfim, Marcela Cristina Correa de Freitas, Virginia Picanco-Castro, Mario Soares de Abreu-Neto, Kamilla Swiech, Dimas Tadeu Covas, Elisa Maria de Sousa Russo;
Human cell lines: a promising alternative for recombinant FIX production.
Protein Expr. Purif. 121:149-156(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AU01
Encyclopedic resources Wikidata; Q54953667
Entry history
Entry creation02-May-2016
Last entry update10-Apr-2025
Version number17