ID   SK-HEP-1-FIX
AC   CVCL_AU01
SY   SK-Hep-1-FIX
DR   cancercelllines; CVCL_AU01
DR   Wikidata; Q54953667
RX   PubMed=26802680;
CC   Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
CC   Population: Caucasian.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; 3551; F9.
CC   Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Endothelial cell; CL=CL_0000115.
DI   NCIt; C7106; Liver and intrahepatic bile duct epithelial neoplasm
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0525 ! SK-HEP-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 10-09-24; Version: 15
//
RX   PubMed=26802680; DOI=10.1016/j.pep.2015.11.023;
RA   de Sousa Bomfim A., Cristina Correa de Freitas M., Picanco-Castro V.,
RA   de Abreu-Neto M.S., Swiech K., Covas D.T., de Sousa Russo E.M.;
RT   "Human cell lines: a promising alternative for recombinant FIX
RT   production.";
RL   Protein Expr. Purif. 121:149-156(2016).
//