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Cellosaurus PANC-1 (CVCL_0480)

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Cell line name PANC-1
Synonyms Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P
Accession CVCL_0480
Resource Identification Initiative To cite this cell line use: PANC-1 (RRID:CVCL_0480)
Comments Part of: AKT genetic alteration cell panel (ATCC TCP-1029).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ENCODE project common cell types; tier 3.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 21 +- 1.6 hours (PubMed=21515691); 25.83 +- 2.03 hours (PubMed=25394408); 25.8 +- 2.8 hours (PubMed=27067801); 52 hours (CLS=300228); ~42 hours (DSMZ=ACC-783); ~32 hours (PBCF); 15.02 hours (JWGray panel).
Karyotypic information: Has lost chromosome Y.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Proteomics.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Caution: Additional TP53 mutation in c.815T>C indicated incorrectly in PubMed=1630814.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
HLA typing Source: PubMed=9023415
Class I
HLA-AA*02:01,11:01
HLA-BB*01,38
HLA-CC*03,12

Source: PubMed=18575732
Class I
HLA-AA*02,11
HLA-BB*01,38
HLA-CC*03,12

Source: PubMed=26589293
Class I
HLA-AA*02:01,11:01
HLA-BB*38:01,38:01
HLA-CC*12:03,12:03
Class II
HLA-DQDQB1*06:07,06:07
HLA-DRDRB1*11:20,14:43

Source: CLS=300228
Class I
HLA-AA*02:01:01,11:01:01
HLA-BB*38:01:01
HLA-CC*12:03:01
Class II
HLA-DPDPB1*12:01:02G,04:02:01G
HLA-DQDQA1*01:03:01
DQB1*06:03:01
HLA-DRDRB1*13:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.26
Native American0
East Asian, North2.09
East Asian, South0
South Asian0
European, North60
European, South35.65
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1778 (1.1B4)CVCL_2257 (1.1E7)CVCL_2259 (1.4E7)
CVCL_E1MD (HyCyte PANC-1 KO-hDTNBP1)CVCL_D6CA (HyCyte PANC-1 KO-hFBXW7)CVCL_E1ME (HyCyte PANC-1 KO-hFN1)
CVCL_E3IA (HyCyte PANC-1-Luc)CVCL_3002 (KP-1N)CVCL_A4BT (PANC-1 Ecadherin EmGFP)
CVCL_WL48 (PANC-1-Cas9-554)CVCL_WL49 (PANC-1-Cas9-555)CVCL_WL50 (PANC-1-Cas9-556)
CVCL_WL51 (PANC-1-Cas9-557)CVCL_WL52 (PANC-1-Cas9-558)CVCL_WL53 (PANC-1-Cas9-559)
CVCL_VQ69 (Panc-1-CTC)CVCL_C8XX (Panc-1-Luc)CVCL_A4BU (PANC-1-Luc2)
CVCL_C0WS (PANC-1/Gem)CVCL_WS13 (PANC-1RG7)CVCL_E9C3 (Panc1-F-RFP)
CVCL_0Q68 (Panc1-MUC1)CVCL_D2RB (PANC1/CD44v3-10)CVCL_E1AI (Ubigene PANC-1 ACLY KO)
CVCL_E1AJ (Ubigene PANC-1 CAV2 KO)CVCL_E1AK (Ubigene PANC-1 PTEN KO)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0018010/4923; ATCC=CRL-1469; CCRID; CLS=300228; DSMZ=ACC-783; ECACC=87092802; KCLB=21469; PubMed=25877200; RCB=RCB2095; Technion Genomics Center; TKG=TKG 0606

Markers:
AmelogeninX
CSF1PO10,12
D1S165612,14
D2S44110,14
D2S133823,24
D3S135817
D5S81811,13
D6S104311,12
D7S8208,10
D8S117914,15
D10S124814
D12S39122
D13S31711
D16S53911
D18S5112
D19S43311,16
D21S1128
D22S104516
FGA21
Penta D14
Penta E7,14
TH017,8
TPOX8,11
vWA15

Run an STR similarity search on this cell line
Web pages Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/panc-1/
Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/PANC-1_Myers_protocol.pdf
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/PANC-1.html
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=65
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544566
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/p/cell-lines-detail-179.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/PANC-1
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/pancreatic-xenograft-models/panc-1-xenograft-model/
Publications

PubMed=1140870; DOI=10.1002/ijc.2910150505
Michael M. Lieber, JoAnn Mazzetta, Walter Anthony Nelson-Rees, Michael Kaplan, George J. Todaro;
Establishment of a continuous tumor-cell line (PANC-1) from a human carcinoma of the exocrine pancreas.
Int. J. Cancer 15:741-747(1975)

PubMed=6435863
Barbara K. Chang, Owen Black Jr., Robert Gutman;
Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
Cancer Res. 44:5100-5104(1984)

PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874
Claire M. Barton, Susan Louise Staddon, Christine M. Hughes, Peter A. Hall, Catriona O'Sullivan, Gunter Kloppel, Belinda Theis, Ronald Christopher Gordon Russell, John Neoptolemos, Robin Charles Noel Williamson, David Philip Lane, Nicholas Robert Lemoine;
Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.
Br. J. Cancer 64:1076-1082(1991)

PubMed=1630814
Bruce Anthony Ruggeri, Shi-Yu Zhang, Jorge Caamano, Marion DiRado, Stuart Dale Flynn, Andres J.P. Klein-Szanto;
Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.
Oncogene 7:1503-1511(1992)

PubMed=7809022; DOI=10.1097/00006676-199409000-00018
Shoichiro Sumi, R. Daniel Beauchamp, Courtney M. Townsend Jr., Parviz M. Pour, Jin Ishizuka, James C. Thompson;
Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation.
Pancreas 9:657-661(1994)

PubMed=7961102; DOI=10.1111/j.1349-7006.1994.tb02898.x; PMCID=PMC5919355
Hirofumi Suwa, Tsunehiro Yoshimura, Nozomi Yamaguchi, Kazunori Kanehira, Tadao Manabe, Masayuki Imamura, Hiroshi Hiai, Manabu Fukumoto;
K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines.
Jpn. J. Cancer Res. 85:1005-1014(1994)

PubMed=8026879; DOI=10.1002/ijc.2910580207
Georgina Berrozpe, James Schaeffer, Miguel Angel Peinado, Francisco X. Real, Manuel Perucho;
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Int. J. Cancer 58:185-191(1994)

PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7
Babette Simon, Rolf Weinel, Martin Hohne, Jutta Watz, Jorg Schmidt, Gunther Kortner, Rudolf Arnold;
Frequent alterations of the tumor suppressor genes p53 and DCC in human pancreatic carcinoma.
Gastroenterology 106:1645-1651(1994)

PubMed=8286197; DOI=10.1038/bjc.1994.24; PMCID=PMC1968784
Johannes-Matthias Lohr, Birgit Trautmann, Martin Gottler, Shirley Peters, Ira Zauner, Bernard Maillet, Gunter Kloppel;
Human ductal adenocarcinomas of the pancreas express extracellular matrix proteins.
Br. J. Cancer 69:144-151(1994)

PubMed=21607521; DOI=10.3892/or.1.6.1223
Haruo Iguchi, Ryoji Morita, Daisuke Yasuda, Ryoichi Takayanagi, Yurika Ikeda, Yutaka Takada, Takao Shimazoe, Hajime Nawata, Akira Kono;
Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in human pancreatic cancer-derived cell-lines with different metastatic potential.
Oncol. Rep. 1:1223-1227(1994)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9788440; DOI=10.1038/sj.onc.1202118
Alberto Villanueva, Carmen Garcia, Ana Belen Paules Blazquez, Monica Vicente, Montse Megias, German Reyes, Priam de Villalonga, Neus Agell, Felix Lluis, Oriol Bachs, Gabriel Capella;
Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.
Oncogene 17:1969-1978(1998)

PubMed=10027410; DOI=10.1016/S0002-9440(10)65298-4; PMCID=PMC1850008
B. Michael Ghadimi, Evelin Schrock, Robert L. Walker, Danny Wangsa, Annukka Jauho, Paul S. Meltzer, Thomas Ried;
Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.
Am. J. Pathol. 154:525-536(1999)

PubMed=11115575; DOI=10.3892/or.8.1.89
Chun-Lan Sun, Takashi Yamato, Toru Furukawa, Yasuyuki Ohnishi, Hiroshi Kijima, Akira Horii;
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncol. Rep. 8:89-92(2001)

PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U
Christine Wallrapp, Susanne Hahnel, Wolfgang Boeck, Anja Soder, Antoaneta Mincheva, Peter Lichter, Gerhard Leder, Frank Gansauge, Claudio Sorio, Aldo Scarpa, Thomas M. Gress;
Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis.
Int. J. Cancer 91:340-344(2001)

PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C
Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn, Patricia A. Gorman, Jeffrey M. Davidson, Denise Sheer, Patrick S. Moore, Aldo Scarpa, Paul A.W. Edwards, Nicholas Robert Lemoine;
Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping.
Int. J. Cancer 91:350-358(2001)

PubMed=11787853; DOI=10.1007/s004280100474
Patrick S. Moore, Bence Sipos, Simonetta Orlandini, Claudio Sorio, Francisco X. Real, Nicholas Robert Lemoine, Thomas M. Gress, Claudio Bassi, Gunter Kloppel, Holger Kalthoff, Hendrik Ungefroren ...Show all 13 authors... , Johannes-Matthias Lohr, Aldo Scarpa; Show fewer authors
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Virchows Arch. 439:798-802(2001)

PubMed=12692724; DOI=10.1007/s00428-003-0784-4
Bence Sipos, Simone Moser, Holger Kalthoff, Virag Torok, Johannes-Matthias Lohr, Gunter Kloppel;
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.
Virchows Arch. 442:444-452(2003)

PubMed=12800145; DOI=10.1002/gcc.10218
Jose Adelaide, Huai-En Huang, Anne Murati, Amber E. Alsop, Beatrice Orsetti, Marie-Joelle Mozziconacci, Cornel Popovici, Christophe Ginestier, Anne Letessier, Celine Basset, Celine Courtay-Cahen ...Show all 16 authors... , Jocelyne Jacquemier, Charles Theillet, Daniel Birnbaum, Paul A.W. Edwards, Max Chaffanet; Show fewer authors
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=14695172
Christine A. Iacobuzio-Donahue, Raheela Ashfaq, Anirban Maitra, Nazmi Volkan Adsay, Grace L.-C. Shen-Ong, Karin Berg, Michael Anthony Hollingsworth, John Lemuel Cameron, Charles J. Yeo, Scott E. Kern, Michael Gilbert Goggins, Ralph H. Hruban;
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.
Cancer Res. 63:8614-8622(2003)

PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159
Markus Heidenblad, Eric F.P.M. Schoenmakers, Tord Jonson, Ludmila Gorunova, Joris A. Veltman, Ad Geurts van Kessel, Mattias Hoglund;
Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines.
Cancer Res. 64:3052-3059(2004)

PubMed=15367885; DOI=10.1097/00006676-200410000-00004
Panayiotis Loukopoulos, Kengo Kanetaka, Masaaki Takamura, Tatsuhiro Shibata, Michiie Sakamoto, Setsuo Hirohashi;
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 29:193-203(2004)

PubMed=15688027; DOI=10.1038/sj.onc.1208383
Markus Heidenblad, David Lindgren, Joris A. Veltman, Tord Jonson, Eija H. Mahlamaki, Ludmila Gorunova, Ad Geurts van Kessel, Eric F.P.M. Schoenmakers, Mattias Hoglund;
Microarray analyses reveal strong influence of DNA copy number alterations on the transcriptional patterns in pancreatic cancer: implications for the interpretation of genomic amplifications.
Oncogene 24:1794-1801(2005)

PubMed=15770730; DOI=10.3748/wjg.v11.i10.1521; PMCID=PMC4305696
Jian-Hua Ma, Emilia Patrut, Jan Schmidt, Hanns-Peter Knaebel, Markus Wolfgang Buchler, Alexandra Marten;
Synergistic effects of interferon-alpha in combination with chemoradiation on human pancreatic adenocarcinoma.
World J. Gastroenterol. 11:1521-1528(2005)

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721
Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern;
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer Res. 66:7920-7928(2006)

PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895
Christian Pilarsky, Ole Ammerpohl, Bence Sipos, Edgar Dahl, Arndt Hartmann, Axel Wellmann, Till Braunschweig, Johannes-Matthias Lohr, Ralf Jesenofsky, Helmut Friess, Moritz Nicolas Wente ...Show all 20 authors... , Glen Kristiansen, Beatrix Jahnke, Axel Denz, Felix Ruckert, Hans Konrad Schackert, Gunter Kloppel, Holger Kalthoff, Hans-Detlev Saeger, Robert Grutzmann; Show fewer authors
Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling.
J. Cell. Mol. Med. 12:2823-2835(2008)

PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928
Ayako Suzuki, Tatsuhiro Shibata, Yutaka Shimada, Yoshinori Murakami, Akira Horii, Keiko Shiratori, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer Sci. 99:986-994(2008)

PubMed=18575732; DOI=10.3892/or.20.1.155
Toru Kawaoka, Masaaki Oka, Motonari Takashima, Tomio Ueno, Koutaro Yamamoto, Noboru Yahara, Shigefumi Yoshino, Shoichi Hazama;
Adoptive immunotherapy for pancreatic cancer: cytotoxic T lymphocytes stimulated by the MUC1-expressing human pancreatic cancer cell line YPK-1.
Oncol. Rep. 20:155-163(2008)

DOI=10.22029/jlupub-12385
Laura Oberlin;
Treatment of pancreatic carcinoma cell lines in vitro and vivo with a monoclonal antibody against the transferrin receptor.
Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany

DOI=10.4172/jpb.1000057
Masayo Yamada, Kiyonaga Fujii, Koji Koyama, Setsuo Hirohashi, Tadashi Kondo;
The proteomic profile of pancreatic cancer cell lines corresponding to carcinogenesis and metastasis.
J. Proteomics Bioinformatics 2:1-18(2009)

PubMed=19077451; DOI=10.1159/000178871
Tomohiko Harada, Claude Chelala, Tatjana Crnogorac-Jurcevic, Nicholas Robert Lemoine;
Genome-wide analysis of pancreatic cancer using microarray-based techniques.
Pancreatology 9:13-24(2009)

PubMed=20037478; DOI=10.4161/cbt.8.21.9685; PMCID=PMC2824894
Oliver A. Kent, Michael E. Mullendore, Eric A. Wentzel, Pedro Lopez-Romero, Aik-Choon Tan, Hector Alvarez, Kristen M. West, Michael F. Ochs, Manuel Hidalgo, Dan E. Arking, Anirban Maitra, Joshua T. Mendell;
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.
Cancer Biol. Ther. 8:2013-2024(2009)

PubMed=20418756; DOI=10.1097/MPA.0b013e3181c15963; PMCID=PMC2860631
Emily L. Deer, Jessica Gonzalez-Hernandez, Jill D. Coursen, Jill E. Shea, Josephat Gichuhi Ngatia, Courtney Lynne Scaife, Matthew A. Firpo, Sean Jordan Mulvihill;
Phenotype and genotype of pancreatic cancer cell lines.
Pancreas 39:425-435(2010)

PubMed=21515691; DOI=10.1074/jbc.M111.226795; PMCID=PMC3121343
Jane T. McCluskey, Muhajir Hamid, Hong Guo-Parke, Neville H. McClenaghan, Ramon Gomis, Peter R. Flatt;
Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion.
J. Biol. Chem. 286:21982-21992(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Katherine E. Varley, Jason Gertz, Kevin M. Bowling, Stephanie L. Parker, Timothy E. Reddy, Florencia Pauli-Behn, Marie K. Cross, Brian A. Williams, John A. Stamatoyannopoulos, Gregory E. Crawford, Devin Michael Absher ...Show all 13 authors... , Barbara Jane Wold, Richard M. Myers; Show fewer authors
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732
Habib Hamidi, Ming Lu, Kevin Chau, Lee Anderson, Marlena Schoenberg Fejzo, Charles Ginther, Ronald Linnartz, Angela Zubel, Dennis Joseph Slamon, Richard Samuel Finn;
KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.
Br. J. Cancer 111:1788-1801(2014)

PubMed=25394408; DOI=10.3892/or.2014.3599
Cong-Fei Wang, Wei-Wei Zhang, Ming-Juan Fu, Ai-Qin Yang, Hsin-Hung Huang, Jie-Ming Xie;
Establishment of human pancreatic cancer gemcitabine-resistant cell line with ribonucleotide reductase overexpression.
Oncol. Rep. 33:383-390(2015)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616
Anneleen Daemen, David Peterson, Nisebita Sahu, Ron McCord, Xiang-Nan Du, Bonnie Liu, Katarzyna Kowanetz, Rebecca Hong, John Moffat, Min Gao, Aaron Boudreau ...Show all 22 authors... , Rana Mroue, Laura Corson, Thomas O'Brien, Jing Qing, Deepak Sampath, Mark Merchant, Robert L. Yauch, Gerard Manning, Jeffrey Settleman, Georgia Hatzivassiliou, Marie Evangelista; Show fewer authors
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26884312; DOI=10.1038/srep21648; PMCID=PMC4756684
Rui Gradiz, Henriqueta Coimbra Silva, Lina Carvalho, Maria Filomena Botelho, Anabela Mota-Pinto;
MIA PaCa-2 and PANC-1 -- pancreas ductal adenocarcinoma cell lines with neuroendocrine differentiation and somatostatin receptors.
Sci. Rep. 6:21648-21648(2016)

PubMed=27067801; DOI=10.1186/s12885-016-2297-y; PMCID=PMC4828819
Kotaro Miura, Kenjiro Kimura, Ryosuke Amano, Sadaaki Yamazoe, Go Ohira, Akihiro Murata, Kohei Nishio, Tsuyoshi Hasegawa, Masakazu Yashiro, Bunzo Nakata, Masaichi Ohira, Kosei Hirakawa;
Establishment and characterization of new cell lines of anaplastic pancreatic cancer, which is a rare malignancy: OCUP-A1 and OCUP-A2.
BMC Cancer 16:268.1-268.13(2016)

PubMed=27259358; DOI=10.1074/mcp.M116.058313; PMCID=PMC4974343
Emily S. Humphrey, Shih-Ping Su, Adnan M. Nagrial, Falko Hochgrafe, Marina Pajic, Gillian M. Lehrbach, Robert G. Parton, Alpha S. Yap, Lisa G. Horvath, David K. Chang, Andrew Victor Biankin ...Show all 13 authors... , Jian-Min Wu, Roger J. Daly; Show fewer authors
Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling.
Mol. Cell. Proteomics 15:2671-2685(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29894427; DOI=10.1097/MPA.0000000000001087
Emily L. Deer, Jessica Gonzalez-Hernandez, Jill D. Coursen, Jill E. Shea, Josephat Gichuhi Ngatia, Courtney Lynne Scaife, Matthew A. Firpo, Sean Jordan Mulvihill;
Erratum to: Phenotype and genotype of pancreatic cancer cell lines.
Pancreas 47:e37-e37(2018)

PubMed=30156359; DOI=10.1111/cas.13783; PMCID=PMC6215881
Taku Sato, Tomoki Muramatsu, Minoru Tanabe, Johji Inazawa;
Identification and characterization of transforming growth factor beta induced in circulating tumor cell subline from pancreatic cancer cell line.
Cancer Sci. 109:3623-3633(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31037374; DOI=10.1007/s00216-019-01814-1
Simon Lagies, Manuel Schlimpert, Lukas M. Braun, Michel Kather, Johannes Plagge, Thalia Erbes, Uwe A. Wittel, Bernd Kammerer;
Unraveling altered RNA metabolism in pancreatic cancer cells by liquid-chromatography coupling to ion mobility mass spectrometry.
Anal. Bioanal. Chem. 411:6319-6328(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
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Cell 180:387-402.e16(2020)

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Zhi-Jing Tan, Jian-Hui Zhu, Paul M. Stemmer, Liang-Liang Sun, Zhi-Chang Yang, Kendall Schultz, Matthew J. Gaffrey, Anthony J. Cesnik, Xin-Pei Yi, Xiao-Hu Hao, Michael R. Shortreed ...Show all 13 authors... , Tu-Jin Shi, David M. Lubman; Show fewer authors
Comprehensive detection of single amino acid variants and evaluation of their deleterious potential in a PANC-1 cell line.
J. Proteome Res. 19:1635-1646(2020)

PubMed=32782605; DOI=10.3892/ol.2020.11825; PMCID=PMC7400074
Kohji Takagi, Johji Imura, Akiko Shimomura, Akira Noguchi, Takashi Minamisaka, Shinichi Tanaka, Takeshi Nishida, Hideki Hatta, Takahiko Nakajima;
Establishment of highly invasive pancreatic cancer cell lines and the expression of IL-32.
Oncol. Lett. 20:2888-2896(2020)

Cross-references
Cell line collections (Providers) AddexBio; C0018010/4923
ATCC; CRL-1469
BCRC; 60284
BCRJ; 0201
CCTCC; GDC0309
CLS; 300228
DSMZ; ACC-783
ECACC; 87092802
IBRC; C10156
IZSLER; BS TCL 49
KCB; KCB 200788YJ
KCB; KCB 200809YJ
KCLB; 21469
NCBI_Iran; C556
RCB; RCB2095
TKG; TKG 0606
Ubigene; YC-C130
Cell line databases/resources CLO; CLO_0008381
CLO; CLO_0050102
MCCL; MCC:0000378
CLDB; cl3872
CLDB; cl3873
CLDB; cl3874
cancercelllines; CVCL_0480
CCRID; 1101HUM-PUMC000023
CCRID; 3101HUMSCSP535
CCRID; 3101HUMTCHu98
CCRID; 4201HUM-CCTCC00309
CCRID; 5301HUM-KCB08009YJ
Cell_Model_Passport; SIDM00610
CGH-DB; 180-1
CGH-DB; 9267-4
DepMap; ACH-000164
DSMZCellDive; ACC-783
LINCS_LDP; LCL-1726
Lonza; 818
SKY/M-FISH/CGH; 2001
TOKU-E; 2865
Anatomy/cell type resources BCGO; BCGO_0000122
BTO; BTO_0000304
Biological sample resources 4DN; 4DNSRDQPS1VU
BioSample; SAMN01821587
BioSample; SAMN03472068
BioSample; SAMN05292439
BioSample; SAMN10987682
ENCODE; ENCBS101NPD
ENCODE; ENCBS314FVF
ENCODE; ENCBS397PLZ
ENCODE; ENCBS399ENC
ENCODE; ENCBS425ENC
ENCODE; ENCBS465AAA
ENCODE; ENCBS466AAA
ENCODE; ENCBS467AAA
ENCODE; ENCBS470AAA
ENCODE; ENCBS492WPY
ENCODE; ENCBS556WYR
ENCODE; ENCBS729QZR
ENCODE; ENCBS761TKL
ENCODE; ENCBS808TSD
ENCODE; ENCBS830QHD
ENCODE; ENCBS945URM
CRISP screens repositories BioGRID_ORCS_Cell_line; 190
Chemistry resources ChEMBL-Cells; CHEMBL3307545
ChEMBL-Targets; CHEMBL614139
PharmacoDB; PANC1_1246_2019
PubChem_Cell_line; CVCL_0480
Encyclopedic resources Wikidata; Q54937550
Experimental variables resources EFO; EFO_0002713
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM206532
GEO; GSM244423
GEO; GSM383934
GEO; GSM472938
GEO; GSM472939
GEO; GSM621900
GEO; GSM784698
GEO; GSM887501
GEO; GSM888583
GEO; GSM923421
GEO; GSM945246
GEO; GSM945261
GEO; GSM1022632
GEO; GSM1024411
GEO; GSM1374806
GEO; GSM1374807
GEO; GSM1374808
GEO; GSM1435699
GEO; GSM1435700
GEO; GSM1435701
GEO; GSM1588613
GEO; GSM1588625
GEO; GSM3333104
GEO; GSM3333105
GEO; GSM3333108
GEO; GSM3333109
Metabolomic databases MetaboLights; MTBLS812
MetaboLights; MTBLS9283
Polymorphism and mutation databases Cosmic; 707250
Cosmic; 710864
Cosmic; 724643
Cosmic; 730533
Cosmic; 753625
Cosmic; 808171
Cosmic; 868242
Cosmic; 873000
Cosmic; 913307
Cosmic; 918054
Cosmic; 922248
Cosmic; 923171
Cosmic; 932521
Cosmic; 947397
Cosmic; 948377
Cosmic; 949235
Cosmic; 968106
Cosmic; 1006367
Cosmic; 1108335
Cosmic; 1122348
Cosmic; 1198204
Cosmic; 1299304
Cosmic; 1320459
Cosmic; 1366282
Cosmic; 1477432
Cosmic; 1518236
Cosmic; 1534320
Cosmic; 1571781
Cosmic; 1609544
Cosmic; 1644316
Cosmic; 1768264
Cosmic; 2434107
Cosmic; 2546060
Cosmic; 2664043
Cosmic; 2755953
IARC_TP53; 317
LiGeA; CCLE_087
Progenetix; CVCL_0480
Proteomic databases PRIDE; PXD002192
PRIDE; PXD003198
PRIDE; PXD032263
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number50