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Cellosaurus PANC-1 Ecadherin EmGFP (CVCL_A4BT)

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Cell line name PANC-1 Ecadherin EmGFP
Synonyms PANC-1 ECAD-EmGFP
Accession CVCL_A4BT
Resource Identification Initiative To cite this cell line use: PANC-1 Ecadherin EmGFP (RRID:CVCL_A4BT)
Comments Population: Caucasian.
Characteristics: Using CRISPR/Cas9 CDH1 has been tagged in one allele at the C-terminus with EmGFP. Allows to monitor the epithelial-to-mesenchymal transition (EMT) status of cells in vitro by monitoring EmGFP expression.
Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; GLAD6; Emerald (Note=EmGFP, green fluorescent protein derived from GFP).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0480 (PANC-1)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1469MET

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,13
D7S8208,10
D13S31711
D16S53911
TH017,8
TPOX8,11
vWA15

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Cross-references
Cell line collections (Providers) ATCC; CRL-1469MET
Cell line databases/resources cancercelllines; CVCL_A4BT
Encyclopedic resources Wikidata; Q105510535
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number8