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Cellosaurus PANC-1/Gem (CVCL_C0WS)

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Cell line name PANC-1/Gem
Synonyms PANC-1/GEM
Accession CVCL_C0WS
Resource Identification Initiative To cite this cell line use: PANC-1/Gem (RRID:CVCL_C0WS)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0480 (PANC-1)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=31410021; DOI=10.2147/OTT.S208924; PMCID=PMC6645696
Bi-Li Wang, Can Shen, Yang Li, Ting Zhang, Hui Huang, Jun Ren, Zheng-Jun Hu, Jian Xu, Bin Xu;
Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling.
Onco Targets Ther. 12:5751-5765(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0WS
Encyclopedic resources Wikidata; Q114312645
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6