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Cellosaurus NALM-6 (CVCL_0092)

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Cell line name NALM-6
Synonyms Nalm-6; NALM 6; Nalm 6; NALM6; Nalm6; NALM-6-M1
Accession CVCL_0092
Resource Identification Initiative To cite this cell line use: NALM-6 (RRID:CVCL_0092)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Population: Caucasian.
Doubling time: 25 hours (PubMed=25984343); 19 hours (PubMed=20922763); 40.2 hours (PubMed=8847894); ~36 hours (DSMZ=ACC-128).
Microsatellite instability: Instable (MSI-high) (PubMed=10739008; PubMed=11226526; PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (PubMed=31243274).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (Cosmic-CLP=908158; DepMap=ACH-000938).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (PubMed=16969076; Cosmic-CLP=908158; DepMap=ACH-000938).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (Cosmic-CLP=908158; DepMap=ACH-000938).
HLA typing Source: PubMed=2939141
Class I
HLA-AA*01,02
HLA-BB*15

Source: PubMed=83966
Class I
HLA-AA*01,02
HLA-BB*08,15

Source: PubMed=26589293
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,15:01
HLA-CC*04:01,07:01

Source: DSMZCellDive=ACC-128
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*08:01:01,15:01:01
HLA-CC*04:01:01,07:01:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,04:01:01
HLA-DQDQA1*02:01:01,02:01:01
DQB1*02:01:01,03:03:02
HLA-DRDRA*01:01:02,01:02:02
DRB1*03:01:01,07:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.12
Native American0.55
East Asian, North0
East Asian, South2.1
South Asian0
European, North75.01
European, South22.21
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8173 (BLIN-1)CVCL_8260 (LR10.6)CVCL_UJ07 (N6-1000)
CVCL_UJ08 (N6-500)CVCL_C4PE (N6-KU70-2-DG)CVCL_UJ06 (N6/ADR)
CVCL_HE04 (NALM-6 DCLRE1C(-/-))CVCL_HE05 (NALM-6 LIG4(-/-))CVCL_HE06 (NALM-6 MUS81(-/-))
CVCL_A4IJ (NALM-6 POLB (-/-))CVCL_HE07 (NALM-6 PRKDC(+/-))CVCL_HE08 (NALM-6 RAD54L(-/-))
CVCL_HE09 (NALM-6 TOP1(+/-))CVCL_HE10 (NALM-6 TOP2B(-/-))CVCL_HE11 (NALM-6 TP53(+/-))
CVCL_HE12 (NALM-6 TP53(-/-))CVCL_HE13 (NALM-6 XRCC5(+/-))CVCL_J365 (Nalm-6-MSH+)
CVCL_UD96 (Nalm-6-TK+/-)CVCL_B7AM (NALM-6/H)CVCL_B7AN (NALM-6/HDR)
CVCL_0U51 (NALM-6/SP-B)CVCL_UJ05 (NALM6, clone G5)CVCL_RA33 (Nalm6-eGFP-Puro)
CVCL_RA35 (Nalm6-Fluc-hNIS)CVCL_RA34 (Nalm6-Fluc-Neo/eGFP-Puro)CVCL_RA36 (Nalm6-Fluc-Puro)
CVCL_4V57 (NALM6/Clo)CVCL_8270 (PBEI)CVCL_JH08 (POLZ CD MSH-)
CVCL_M249 (POLZ KO MSH-)
Originate from same individual CVCL_WW76 ! B85
CVCL_5677 ! NALM-7
CVCL_L057 ! NALM-8
CVCL_L058 ! NALM-9
CVCL_L059 ! NALM-10
CVCL_L060 ! NALM-11
CVCL_5660 ! NALM-12
CVCL_L061 ! NALM-13
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003030/5015; COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=11416159; PubMed=20922763; PubMed=25877200; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413

Markers:
AmelogeninX,Y
CSF1PO12 (AddexBio=C0003030/5015; COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=25877200)
12,13 (PubMed=20922763; PubMed=34823530)
13 (RCB=RCB1933; TKG=TKG 0413)
D2S44110,14
D2S133817,24
D3S135815,16,17 (PubMed=20922763)
16,17 (COG; DSMZ=ACC-128; PubMed=25877200; PubMed=34823530)
D5S81810,11,12 (COG; DSMZ=ACC-128; PubMed=25877200)
11 (AddexBio=C0003030/5015)
11,12 (Cosmic-CLP=908158; PubMed=20922763; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413)
D6S104311
D7S8208,9,10 (Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=25877200)
8,10 (PubMed=34823530)
8,11 (RCB=RCB1933; TKG=TKG 0413)
8,11,12 (PubMed=20922763)
8,12 (AddexBio=C0003030/5015)
10 (COG)
D8S117911,13,14 (COG; DSMZ=ACC-128; PubMed=25877200)
12,13 (PubMed=20922763)
D13S3178,9,11,12 (DSMZ=ACC-128; PubMed=34823530)
8,9,12 (COG)
9,11 (AddexBio=C0003030/5015)
9,12 (Cosmic-CLP=908158; PubMed=25877200)
9,12,13 (PubMed=20922763)
9,13 (RCB=RCB1933; TKG=TKG 0413)
D16S5399,10,11 (COG; DSMZ=ACC-128; PubMed=34823530)
10,11 (Cosmic-CLP=908158; PubMed=20922763; PubMed=25877200; RCB=RCB1933; TKG=TKG 0413)
11 (AddexBio=C0003030/5015)
D18S5111,12,14,15 (PubMed=20922763)
12,15 (COG; DSMZ=ACC-128; PubMed=25877200)
D19S43312,13,15 (PubMed=20922763)
13,15 (COG; DSMZ=ACC-128)
D21S1128,29
FGA21,22 (COG)
21,22,23 (DSMZ=ACC-128)
22 (PubMed=11416159; PubMed=25877200)
22,23 (PubMed=20922763; PubMed=34823530)
Penta D8,14
Penta E11
TH018 (PubMed=11416159; PubMed=25877200)
8,9 (AddexBio=C0003030/5015; COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=20922763; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413)
TPOX8,10
vWA15,16 (COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=20922763; PubMed=25877200; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413)
15,18 (AddexBio=C0003030/5015)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-607.html
Provider; CCR; -; https://www.cccells.org/cellreqs-ncipptp.php
Publications

CLPUB00085
Jun Minowada, Mitsuo Oshimura, Syuiti Abe, Melvyn Francis Greaves, George Janossy, Avery Aba Sandberg;
Human leukemia cell lines. Evidence for differentiation toward T- and B-cell axis within a leukemia clone.
Proc. Am. Assoc. Cancer Res. 19:109.434-109.434(1978)

PubMed=155647; PMCID=PMC1457255
Tin Han, Jun Minowada;
Use of stimulating capacity of mixed lymphocyte reaction (MLR-S) as a possible marker for the cell-origin of null-cell acute lymphoblastic leukaemia.
Immunology 35:333-339(1978)

PubMed=83966; DOI=10.1002/ijc.2910230206
Richard Hurwitz, John C. Hozier, Tucker W. LeBien, Jun Minowada, Kazimiera Gajl-Peczalska, Ichiro Kubonishi, John H. Kersey;
Characterization of a leukemic cell line of the pre-B phenotype.
Int. J. Cancer 23:174-180(1979)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2415623; DOI=10.4049/jimmunol.136.1.320
Victor S. Goldmacher, John M. Lambert, Annie Yau Young, Jean Anderson, Nancy L. Tinnel, Mary Kornacki, Jerome Ritz, Walter A. Blattler;
Expression of the common acute lymphoblastic leukemia antigen (CALLA) on the surface of individual cells of human lymphoblastoid lines.
J. Immunol. 136:320-325(1986)

PubMed=2939141; DOI=10.4049/jimmunol.136.11.4311
John M. Pesando, Lynn Graf;
Differential expression of HLA-DR, -DQ, and -DP antigens on malignant B cells.
J. Immunol. 136:4311-4318(1986)

PubMed=2783384
Yi Luo, Hideki Hara, Yuro Haruta, Ben K. Seon;
Establishment of ascitic tumor of human pre-B acute lymphoblastic leukemia in nonconditioned nude mice.
Cancer Res. 49:706-710(1989)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=8847894
Akiyoshi Tani, Eiji Tatsumi, Fumihiko Nakamura, Shunichi Kumagai, Yoshiyuki Kosaka, Kimihiko Sano, Hajime Nakamura, Ryuichi Amakawa, Hitoshi Ohno;
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Cord C. Uphoff, Roderick A.F. MacLeod, Sabine A. Denkmann, Todd Robert Golub, Arndt Borkhardt, Johannes W.G. Janssen, Hans Gunther Drexler;
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Yoshinobu Matsuo, Hans Gunther Drexler;
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10490826; DOI=10.1038/sj.onc.1202874
Xin-Yu Fu, Shannon McGrath, Martina P. Pasillas, Shinpei Nakazawa, Mark P. Kamps;
EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.
Oncogene 18:4920-4929(1999)

PubMed=10695022
Yoshinobu Matsuo, Chiharu Nishizaki, Hans Gunther Drexler;
Efficient DNA fingerprinting method for the identification of cross-culture contamination of cell lines.
Hum. Cell 12:149-154(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Marcin Majka, Tomasz Rozmyslowicz, Marek J. Honczarenko, Janina Ratajczak, Mariusz A. Wasik, Glen N. Gaulton, Mariusz Zdzislaw Ratajczak;
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11986953; DOI=10.1038/sj.leu.2402485
Peter H. O'Donnell, Wei-Xing Guo, Charles Patrick Reynolds, Barry J. Maurer;
N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.
Leukemia 16:902-910(2002)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16405397; DOI=10.1089/dna.2006.25.19
Noritaka Adachi, Sairei So, Susumu Iiizumi, Yuji Nomura, Kyoko Murai, Chie Yamakawa, Kiyoshi Miyagawa, Hideki Koyama;
The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination.
DNA Cell Biol. 25:19-24(2006)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16969076; DOI=10.4161/cbt.5.8.3251; PMCID=PMC2714972
Sarah Edkins, Sarah O'Meara, Adrian Parker, Claire Stevens, Marcelo Reis, Sian Jones, Christopher D. Greenman, Helen R. Davies, Gillian L. Dalgliesh, Simon Forbes, Chris Hunter ...Show all 21 authors... , Raffaella Smith, Philip J. Stephens, Peter Goldstraw, Andrew Nicholson, Tsun-Leung Chan, Victor E. Velculescu, Siu Tsan Yuen, Suet Yi Leung, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Recurrent KRAS codon 146 mutations in human colorectal cancer.
Cancer Biol. Ther. 5:928-932(2006)

PubMed=20103924
Noritaka Adachi, Hitoshi Nishijima, Kei-ichi Shibahara;
Gene targeting using the human Nalm-6 pre-B cell line.
Biosci. Trends 2:169-180(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455
Takeshi Inukai, Xiu-Ru Zhang, Takeshi Kameyama, Yukiko Suzuki, Kazuhito Yoshikawa, Itaru Kuroda, Atsushi Nemoto, Koshi Akahane, Hiroki Sato, Kumiko Goi, Kazunori Nakamoto ...Show all 15 authors... , Jun-ichi Hamada, Mitsuhiro Tada, Tetsuya Moriuchi, Kanji Sugita; Show fewer authors
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
Am. J. Hematol. 85:535-537(2010)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Min H. Kang, Malcolm A. Smith, Christopher L. Morton, Nino Keshelava, Peter J. Houghton, Charles Patrick Reynolds;
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23596518; DOI=10.1371/journal.pone.0061189; PMCID=PMC3626652
Tetsuya Suzuki, Akiko Ukai, Masamitsu Honma, Noritaka Adachi, Takehiko Nohmi;
Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting.
PLoS ONE 8:e61189.1-e61189.10(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

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Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
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Int. J. Hematol. 108:312-318(2018)

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Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

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Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

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Li-Qing Tian, Ying Shao, Stephanie Nance, Jin-Jun Dang, Bei-Si Xu, Xiao-Tu Ma, Yong-Jin Li, Ben-Sheng Ju, Li Dong, Scott Newman, Xin Zhou ...Show all 19 authors... , Patrick Schreiner, Elizabeth Tseng, Ting Hon, Meredith Howard Ashby, Chun-Liang Li, John Easton, Tanja Andrea Gruber, Jing-Hui Zhang; Show fewer authors
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia.
Nat. Commun. 10:2789.1-2789.10(2019)

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Atsushi Watanabe, Takeshi Inukai, Keiko Kagami, Masako Abe, Masatoshi Takagi, Takashi Fukushima, Hiroko Fukushima, Toru Nanmoku, Kiminori Terui, Tatsuya Ito, Tsutomu Toki ...Show all 29 authors... , Etsuro Ito, Junya Fujimura, Hiroaki Goto, Mikiya Endo, Thomas Look, Mark P. Kamps, Masayoshi Minegishi, Junko Takita, Toshiya Inaba, Hiroyuki Takahashi, Akira Ohara, Daisuke Harama, Tamao Shinohara, Shinpei Somazu, Hiroko Oshiro, Koshi Akahane, Kumiko Goi, Kanji Sugita; Show fewer authors
Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy.
Cancer Med. 8:5274-5288(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

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Yuan-Yuan Li, Chuan Zuo, Ling Gu;
Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition.
Cancer Cell Int. 21:623.1-623.14(2021)

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J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

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Nat. Commun. 13:1691.1-1691.19(2022)

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Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0003030/5015
CLS; 300297
DSMZ; ACC-128
NCBI_Iran; C212
RCB; RCB1933
TKG; TKG 0413
Cell line databases/resources CLO; CLO_0007938
CLO; CLO_0050970
CLDB; cl3631
CLDB; cl3632
cancercelllines; CVCL_0092
Cell_Model_Passport; SIDM00429
Cosmic-CLP; 908158
DepMap; ACH-000938
DSMZCellDive; ACC-128
IGRhCellID; NALM6
LINCS_LDP; LCL-1007
Lonza; 812
Anatomy/cell type resources BTO; BTO_0003288
Biological sample resources BioSample; SAMN03472035
BioSample; SAMN03473163
BioSample; SAMN03473413
BioSample; SAMN10988491
CRISP screens repositories BioGRID_ORCS_Cell_line; 273
Chemistry resources ChEMBL-Cells; CHEMBL3307559
ChEMBL-Targets; CHEMBL614187
GDSC; 908158
PharmacoDB; NALM6_980_2019
PubChem_Cell_line; CVCL_0092
Encyclopedic resources Wikidata; Q54907426
Experimental variables resources EFO; EFO_0002245
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
FANTOM5_SSTAR; 10534-107G3
GEO; GSM236797
GEO; GSM236833
GEO; GSM887347
GEO; GSM888423
GEO; GSM1670142
GEO; GSM5137734
Polymorphism and mutation databases Cosmic; 801722
Cosmic; 850385
Cosmic; 889112
Cosmic; 908158
Cosmic; 919147
Cosmic; 991553
Cosmic; 998708
Cosmic; 999748
Cosmic; 1012106
Cosmic; 1037711
Cosmic; 1070706
Cosmic; 1093787
Cosmic; 1130246
Cosmic; 1191699
Cosmic; 1483361
Cosmic; 1509198
Cosmic; 1524810
Cosmic; 2491082
Cosmic; 2649232
IARC_TP53; 21527
LiGeA; CCLE_665
Progenetix; CVCL_0092
Proteomic databases PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number50