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Cellosaurus NALM-6 (CVCL_0092)

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Cell line name NALM-6
Synonyms Nalm-6; NALM 6; Nalm 6; NALM6; Nalm6; NALM-6-M1
Accession CVCL_0092
Resource Identification Initiative To cite this cell line use: NALM-6 (RRID:CVCL_0092)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Population: Caucasian.
Doubling time: 25 hours (PubMed=25984343); 19 hours (PubMed=20922763); 40.2 hours (PubMed=8847894); ~36 hours (DSMZ=ACC-128).
Microsatellite instability: Instable (MSI-high) (PubMed=10739008; PubMed=11226526; PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Deep quantitative proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (PubMed=31243274).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (Cosmic-CLP=908158; DepMap=ACH-000938).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (PubMed=16969076; Cosmic-CLP=908158; DepMap=ACH-000938).
  • Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (Cosmic-CLP=908158; DepMap=ACH-000938).
HLA typing Source: PubMed=2939141
Class I

Source: PubMed=83966
Class I

Source: PubMed=26589293
Class I

Source: DSMZCellDive=ACC-128
Class I
Class II
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.55
East Asian, North0
East Asian, South2.1
South Asian0
European, North75.01
European, South22.21
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8173 (BLIN-1)CVCL_8260 (LR10.6)CVCL_UJ07 (N6-1000)
CVCL_UJ08 (N6-500)CVCL_C4PE (N6-KU70-2-DG)CVCL_UJ06 (N6/ADR)
CVCL_HE04 (NALM-6 DCLRE1C(-/-))CVCL_HE05 (NALM-6 LIG4(-/-))CVCL_HE06 (NALM-6 MUS81(-/-))
CVCL_A4IJ (NALM-6 POLB (-/-))CVCL_HE07 (NALM-6 PRKDC(+/-))CVCL_HE08 (NALM-6 RAD54L(-/-))
CVCL_HE09 (NALM-6 TOP1(+/-))CVCL_HE10 (NALM-6 TOP2B(-/-))CVCL_HE11 (NALM-6 TP53(+/-))
CVCL_HE12 (NALM-6 TP53(-/-))CVCL_HE13 (NALM-6 XRCC5(+/-))CVCL_J365 (Nalm-6-MSH+)
CVCL_UD71 (Nalm-6-MSH+/TK+/-)CVCL_UD96 (Nalm-6-TK+/-)CVCL_B7AM (NALM-6/H)
CVCL_RA33 (Nalm6-eGFP-Puro)CVCL_RA35 (Nalm6-Fluc-hNIS)CVCL_RA34 (Nalm6-Fluc-Neo/eGFP-Puro)
CVCL_RA36 (Nalm6-Fluc-Puro)CVCL_4V57 (NALM6/Clo)CVCL_8270 (PBEI)
Originate from same individual CVCL_WW76 ! B85
CVCL_5677 ! NALM-7
CVCL_L057 ! NALM-8
CVCL_L058 ! NALM-9
CVCL_L059 ! NALM-10
CVCL_L060 ! NALM-11
CVCL_5660 ! NALM-12
CVCL_L061 ! NALM-13
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003030/5015; COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=11416159; PubMed=20922763; PubMed=25877200; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413

CSF1PO12 (AddexBio=C0003030/5015; COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=25877200)
12,13 (PubMed=20922763; PubMed=34823530)
13 (RCB=RCB1933; TKG=TKG 0413)
D3S135815,16,17 (PubMed=20922763)
16,17 (COG; DSMZ=ACC-128; PubMed=25877200; PubMed=34823530)
D5S81810,11,12 (COG; DSMZ=ACC-128; PubMed=25877200)
11 (AddexBio=C0003030/5015)
11,12 (Cosmic-CLP=908158; PubMed=20922763; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413)
D7S8208,12 (AddexBio=C0003030/5015)
8,9,10 (Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=25877200)
8,10 (PubMed=34823530)
8,11 (RCB=RCB1933; TKG=TKG 0413)
8,11,12 (PubMed=20922763)
10 (COG)
D8S117911,13,14 (COG; DSMZ=ACC-128; PubMed=25877200)
12,13 (PubMed=20922763)
D13S3178,9,11,12 (DSMZ=ACC-128; PubMed=34823530)
8,9,12 (COG)
9,11 (AddexBio=C0003030/5015)
9,12 (Cosmic-CLP=908158; PubMed=25877200)
9,12,13 (PubMed=20922763)
9,13 (RCB=RCB1933; TKG=TKG 0413)
D16S5399,10,11 (COG; DSMZ=ACC-128; PubMed=34823530)
10,11 (Cosmic-CLP=908158; PubMed=20922763; PubMed=25877200; RCB=RCB1933; TKG=TKG 0413)
11 (AddexBio=C0003030/5015)
D18S5111,12,14,15 (PubMed=20922763)
12,15 (COG; DSMZ=ACC-128; PubMed=25877200)
D19S43312,13,15 (PubMed=20922763)
13,15 (COG; DSMZ=ACC-128)
FGA21,22 (COG)
21,22,23 (DSMZ=ACC-128)
22 (PubMed=11416159; PubMed=25877200)
22,23 (PubMed=20922763; PubMed=34823530)
Penta D8,14
Penta E11
TH018 (PubMed=11416159; PubMed=25877200)
8,9 (AddexBio=C0003030/5015; COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=20922763; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413)
vWA15,16 (COG; Cosmic-CLP=908158; DSMZ=ACC-128; PubMed=20922763; PubMed=25877200; PubMed=34823530; RCB=RCB1933; TKG=TKG 0413)
15,18 (AddexBio=C0003030/5015)

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-607.html

Minowada J., Oshimura M., Abe S., Greaves M.F., Janossy G., Sandberg A.A.
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Leuk. Res. 9:209-229(1985)

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Drexler H.G., Gaedicke G., Minowada J.
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Leuk. Res. 9:549-559(1985)

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PubMed=2415623; DOI=10.4049/jimmunol.136.1.320
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Tani A., Tatsumi E., Nakamura F., Kumagai S., Kosaka Y., Sano K., Nakamura H., Amakawa R., Ohno H.
Sensitivity to dexamethasone and absence of bcl-2 protein in Burkitt's lymphoma cell line (Black93) derived from a patient with acute tumor lysis syndrome: comparative study with other BL and non-BL lines.
Leukemia 10:1592-1603(1996)

PubMed=9067587; DOI=10.1038/sj.leu.2400571
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Leukemia 11:441-447(1997)

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Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
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Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
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Leuk. Res. 22:567-579(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
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EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.
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Matsuo Y., Nishizaki C., Drexler H.G.
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Hum. Cell 12:149-154(1999)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
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Leuk. Res. 24:255-262(2000)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
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Leukemia 14:1821-1832(2000)

Drexler H.G.
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Leuk. Res. 25:275-278(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198
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Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11986953; DOI=10.1038/sj.leu.2402485
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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.
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PubMed=15843827; DOI=10.1038/sj.leu.2403749
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PubMed=16405397; DOI=10.1089/dna.2006.25.19
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The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination.
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PubMed=16408098; DOI=10.1038/sj.leu.2404081
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Leukemia 20:471-476(2006)

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Adachi N., Nishijima H., Shibahara K.-i.
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Biosci. Trends 2:169-180(2008)

PubMed=20164919; DOI=10.1038/nature08768
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PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
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PubMed=20575032; DOI=10.1002/ajh.21738
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PubMed=20922763; DOI=10.1002/pbc.22801
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PLoS ONE 8:E61189-E61189(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
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PubMed=25485619; DOI=10.1038/nbt.3080
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PubMed=25877200; DOI=10.1038/nature14397
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PubMed=26589293; DOI=10.1186/s13073-015-0240-5
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PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
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PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
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PubMed=29786757; DOI=10.1007/s12185-018-2474-7
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PubMed=30285677; DOI=10.1186/s12885-018-4840-5
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PubMed=30629668; DOI=10.1371/journal.pone.0210404
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PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
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PubMed=31068700; DOI=10.1038/s41586-019-1186-3
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Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=31243274; DOI=10.1038/s41467-019-10637-8
Tian L.-Q., Shao Y., Nance S., Dang J.-J., Xu B.-S., Ma X.-T., Li Y.-J., Ju B.-S., Dong L., Newman S., Zhou X., Schreiner P., Tseng E., Hon T., Ashby M., Li C.-L., Easton J., Gruber T.A., Zhang J.-H.
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia.
Nat. Commun. 10:2789.1-2789.10(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=34823530; DOI=10.1186/s12935-021-02335-7
Li Y.-Y., Zuo C., Gu L.
Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition.
Cancer Cell Int. 21:623.1-623.14(2021)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5
Leo I.R., Aswad L., Stahl M., Kunold E., Post F., Erkers T., Struyf N., Mermelekas G., Joshi R.N., Gracia-Villacampa E., Ostling P., Kallioniemi O.-P., Pokrovskaja Tamm K., Siavelis I., Lehtio J., Vesterlund M., Jafari R.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) AddexBio; C0003030/5015
CLS; 300297
NCBI_Iran; C212
RCB; RCB1933
TKG; TKG 0413
Cell line databases/resources CLO; CLO_0007938
CLO; CLO_0050970
CLDB; cl3631
CLDB; cl3632
cancercelllines; CVCL_0092
Cell_Model_Passport; SIDM00429
Cosmic-CLP; 908158
DepMap; ACH-000938
DSMZCellDive; ACC-128
Lonza; 812
Anatomy/cell type resources BTO; BTO:0003288
Biological sample resources BioSample; SAMN03472035
BioSample; SAMN03473163
BioSample; SAMN03473413
BioSample; SAMN10988491
CRISP screens repositories BioGRID_ORCS_Cell_line; 273
Chemistry resources ChEMBL-Cells; CHEMBL3307559
ChEMBL-Targets; CHEMBL614187
GDSC; 908158
PharmacoDB; NALM6_980_2019
PubChem_Cell_line; CVCL_0092
Encyclopedic resources Wikidata; Q54907426
Experimental variables resources EFO; EFO_0002245
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236797
GEO; GSM236833
GEO; GSM887347
GEO; GSM888423
GEO; GSM1670142
GEO; GSM5137734
Polymorphism and mutation databases Cosmic; 801722
Cosmic; 850385
Cosmic; 889112
Cosmic; 908158
Cosmic; 919147
Cosmic; 991553
Cosmic; 998708
Cosmic; 999748
Cosmic; 1012106
Cosmic; 1037711
Cosmic; 1070706
Cosmic; 1093787
Cosmic; 1130246
Cosmic; 1191699
Cosmic; 1483361
Cosmic; 1509198
Cosmic; 1524810
Cosmic; 2491082
Cosmic; 2649232
IARC_TP53; 21527
LiGeA; CCLE_665
Progenetix; CVCL_0092
Proteomic databases PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number47