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Cellosaurus BLIN-1 (CVCL_8173)

[Text version]
Cell line name BLIN-1
Synonyms Blin-1; Blin1; B-lineage 1
Accession CVCL_8173
Resource Identification Initiative To cite this cell line use: BLIN-1 (RRID:CVCL_8173)
Comments Problematic cell line: Contaminated. Shown to be a NALM-6 derivative (PubMed=12592342; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00170.
Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
CVCL_L811 (1E8 [Human leukemia])
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=2642502; DOI=10.4049/jimmunol.142.1.110
Wormann B., Anderson J.M., Liberty J.A., Gajl-Peczalska K., Brunning R.D., Silberman T.L., Arthur D.C., LeBien T.W.
Establishment of a leukemic cell model for studying human pre-B to B cell differentiation.
J. Immunol. 142:110-117(1989)

PubMed=7919343; DOI=10.1182/blood.V84.7.2253.2253
Renard N., Duvert V., Banchereau J., Saeland S.
Interleukin-13 inhibits the proliferation of normal and leukemic human B-cell precursors.
Blood 84:2253-2260(1994)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cell line databases/resources cancercelllines; CVCL_8173
Biological sample resources BioSample; SAMN03151850
Encyclopedic resources Wikidata; Q54797358
Gene expression databases GEO; GSM3145692
Polymorphism and mutation databases Cosmic; 1070705
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number29