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Cellosaurus NALM6/Clo (CVCL_4V57)

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Cell line name NALM6/Clo
Accession CVCL_4V57
Resource Identification Initiative To cite this cell line use: NALM6/Clo (RRID:CVCL_4V57)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_681569; Clofarabine (CAFdA).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=25461250; DOI=10.1016/j.exphem.2014.11.001
Miho Yamanishi, Hidehiko Narazaki, Takeshi Asano;
Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase.
Exp. Hematol. 43:207-214(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V57
Encyclopedic resources Wikidata; Q54907446
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number15