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Cellosaurus N6-KU70-2-DG (CVCL_C4PE)

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Cell line name N6-KU70-2-DG
Accession CVCL_C4PE
Resource Identification Initiative To cite this cell line use: N6-KU70-2-DG (RRID:CVCL_C4PE)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4055; XRCC6.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0092 (NALM-6)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=36162731; DOI=10.1016/j.bbagen.2022.130246
Dipayan Ghosh, Namrata Madan Nilavar, Sathees C. Raghavan;
A novel KU70-mutant human leukemic cell line generated using CRISPR-Cas9 shows increased sensitivity to DSB inducing agents and reduced NHEJ activity.
Biochim. Biophys. Acta 1866:130246.1-130246.11(2022)

Cross-references
Encyclopedic resources Wikidata; Q116049861
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number5