Cellosaurus cell line NALM-6 POLB (-/-) (CVCL

Cross-references
Cell line name	NALM-6 POLB (-/-)
Synonyms	POLB (-/-) NALM-6
Accession	CVCL_A4IJ
Resource Identification Initiative	To cite this cell line use: NALM-6 POLB (-/-) (RRID:CVCL_A4IJ)
Comments	Population: Caucasian. Knockout cell: Method=Homologous recombination; HGNC; HGNC:9174; POLB. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations	Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line). Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease	Adult B acute lymphoblastic leukemia (NCIt: C9143) Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0092 (NALM-6)
Sex of cell	Male
Age at sampling	19Y
Category	Cancer cell line
Cell line collections (Providers)	Horizon_Discovery; HD+115-051
Cell line databases/resources	cancercelllines; CVCL_A4IJ
Encyclopedic resources	Wikidata; Q105510283
Entry history
Entry creation	12-Jan-2021
Last entry update	19-Dec-2024
Version number	8