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Cellosaurus P3HR-1 (CVCL_2676)

[Text version]
Cell line name P3HR-1
Synonyms P 3 HR 1; P3HR1; P3HRI; P3HR1-BL; P3J HR-1; P3J-HR-1; P3JHR-1; P3JHR1; P3JHRI; P3J HR1-K; P3J.HR1K; HR-1; HR1; HRI; HR1K; PO
Accession CVCL_2676
Secondary accession CVCL_A1FV
Resource Identification Initiative To cite this cell line use: P3HR-1 (RRID:CVCL_2676)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
Population: African; Nigerian.
Doubling time: 17 hours (PubMed=8402660).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq virome analysis.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: HAI; Cosmic=2808228.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*58:01,58:01
HLA-CC*04:01,04:01

Source: CLS=302310
Class I
HLA-AA*03:01:01,74:01:01
HLA-BB*53:01:01,58:01:01
HLA-CC*04:01:01
Class II
HLA-DPDPB1*01:01:01,02:01:02
HLA-DQDQA1*01:02:01,05:05:01
DQB1*03:19:01,06:02:01
HLA-DRDRB1*11:02:01,15:03:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African97.8
Native American0
East Asian, North0.68
East Asian, South0
South Asian0
European, North0
European, South1.51
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1317 (Jiyoye)
Children:
CVCL_X203 (D98/HR-1)CVCL_IU56 (FF452-3)CVCL_IU57 (GG618-13)
CVCL_W740 (HH514-16)CVCL_W741 (HH543-5)CVCL_E4CV (HRI +2)
CVCL_B066 (P3H3)CVCL_ZI14 (PICAT)CVCL_ZI15 (PICATPO-1)
CVCL_ZI12 (PUT)CVCL_C5DN (sfP3HR-1)CVCL_8428 (TDL-1)
CVCL_8429 (TDL-2)
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-62; CLS=302310; ECACC=86010701

Markers:
AmelogeninX (CLS=302310; ECACC=86010701)
X,Y (ATCC=HTB-62)
CSF1PO10,11
D2S133821
D3S135816,17
D5S81812
D7S8208,10
D8S117914,15
D13S31712
D16S53910,11
D18S5112,19
D19S43312,15
D21S1128,36
FGA23,24
Penta D2.2,12
Penta E8
TH017,9
TPOX6,8
vWA15,18,19 (CLS=302310)
15,19 (ATCC=HTB-62; ECACC=86010701)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=4912237; DOI=10.1128/JVI.1.5.1045-1051.1967; PMCID=PMC375384
Yorio Hinuma, Mitsuru Konn, Junji Yamaguchi, Donald J. Wudarski, James R. Blakeslee Jr., James Thomas Grace Jr.;
Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line.
J. Virol. 1:1045-1051(1967)

PubMed=4321017; DOI=10.1002/ijc.2910060315
Frederick E. Durr, James H. Monroe, Rene Schmitter, Karl A. Traul, Yashar Hirshaut;
Studies on the infectivity and cytopathology of Epstein-Barr virus in human lymphoblastoid cells.
Int. J. Cancer 6:436-449(1970)

PubMed=4321974
Bruce A. Maurer, Tatsuo Imamura, Sharon M. Wilbert;
Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt lymphoma cell lines.
Cancer Res. 30:2870-2875(1970)

PubMed=4932228; DOI=10.1002/ijc.2910070214
Lajos Gergely, George Klein, Ingemar Ernberg;
The action of DNA antagonists on Epstein-Barr virus (EBV)-associated early antigen (EA) in Burkitt lymphoma lines.
Int. J. Cancer 7:293-302(1971)

PubMed=4115493
P. Petit, Alain Verhest, Fritsje A. Lecluse-van der Bilt, Ans P.M. Jongsma;
The chromosomes of the EB virus-positive Burkitt cell line P3J.HR1K studied by the fluorescent staining technique.
Pathol. Eur. 7:17-21(1972)

PubMed=4122458; DOI=10.1002/ijc.2910100108
George Klein, Laszlo Dombos, Balwant Gothoskar;
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.
Int. J. Cancer 10:44-57(1972)

PubMed=4364259; DOI=10.1002/ijc.2910110210
George Klein, Laszlo Dombos;
Relationship between the sensitivity of EBV-carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genome.
Int. J. Cancer 11:327-337(1973)

PubMed=168255; DOI=10.4049/jimmunol.115.1.243
Lindsey M. Hutt, Yung-Tsun Huang, Harry Emerson Dascomb, Joseph S. Pagano;
Enhanced destruction of lymphoid cell lines by peripheral blood leukocytes taken from patients with acute infectious mononucleosis.
J. Immunol. 115:243-248(1975)

PubMed=170370; DOI=10.1099/0022-1317-28-2-207
Alice Adams, Hans Strander, Kari Cantell;
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
J. Gen. Virol. 28:207-217(1975)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=913957; DOI=10.20772/cancersci1959.68.3_357
Tetsuo Inada, Tsutomu Kasuga, Ichi Nojiri, Takeshi Hiraoka, Takeshi Furuse;
Comparative study on radiosensitivities of cultured cell lines derived from several human tumors under hypoxic condition.
Gann 68:357-362(1977)

PubMed=6265077
Philip A. Pizzo, Sisir K. Chattopadhyay, Ian Trevor Magrath, Eric Del Giacco, D.W. Sherrick, Thomas E. Gray;
Examination of Epstein-Barr virus and C-type proviral sequences in American and African lymphomas and derivative cell lines.
Cancer Res. 41:3165-3171(1981)

PubMed=6278187; DOI=10.1093/jnci/68.2.179
Jesper Zeuthen, George Klein, Rosalie Ber, Giuseppe Masucci, Susanne Bisballe, Susan Povey, Paul Ichiro Terasaki, Peter Ralph;
Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. I Isolation, characterization, cell surface markers, and B-cell markers.
J. Natl. Cancer Inst. 68:179-195(1982)

PubMed=6278188; DOI=10.1093/jnci/68.2.197
George Klein, Jesper Zeuthen, Rosalie Ber, Ingemar Ernberg;
Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. II Epstein-Barr virus induction patterns.
J. Natl. Cancer Inst. 68:197-202(1982)

PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336
David Benjamin, Ian Trevor Magrath, Robert T. Maguire, Carol Janus, Heather D. Todd-Kulikowsk, Robert G. Parsons;
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)

PubMed=6287082; DOI=10.1093/jnci/69.3.585
Paul Gerber, Dharam Vir Ablashi, Ian Trevor Magrath, Gary R. Armstrong, Philip Andersen, Luba Trach;
Persistence of transforming and nontransforming Epstein-Barr virus in high passages of P3HR-1 cell lines.
J. Natl. Cancer Inst. 69:585-590(1982)

PubMed=6231253; DOI=10.1002/ijc.2910330407
Barbro Ehlin-Henriksson, George Klein;
Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.
Int. J. Cancer 33:459-463(1984)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x; PMCID=PMC452998
Paul J. Farrell, Gordon J. Allan, Frances Shanahan, Karen Heather Vousden, Tim Crook;
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883
Gianluca Gaidano, Paola Ballerini, Jerry Z. Gong, Giorgio Inghirami, Antonino Neri, Elizabeth W. Newcomb, Ian Trevor Magrath, Daniel M. Knowles, Riccardo Dalla-Favera;
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=8220424; DOI=10.1038/ng0993-56
Kishor G. Bhatia, Konrad Huppi, Gordon Spangler, David Siwarski, Radhika Iyer, Ian Trevor Magrath;
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
Nat. Genet. 5:56-61(1993)

PubMed=8344493; DOI=10.1096/fasebj.7.10.8344493
Kishor G. Bhatia, Walter Goldschmidts, Marina I. Gutierrez, Gianluca Gaidano, Riccardo Dalla-Favera, Ian Trevor Magrath;
Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.
FASEB J. 7:951-956(1993)

PubMed=8402660
Patrick M. O'Connor, Joany Jackman, Daniel Jondle, Kishor G. Bhatia, Ian Trevor Magrath, Kurt W. Kohn;
Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.
Cancer Res. 53:4776-4780(1993)

PubMed=8108117
Thomas Albert, Birgit Urlbauer, Franz Kohlhuber, Bettina Hammersen, Dirk Eick;
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
Oncogene 9:759-763(1994)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x; PMCID=PMC11160262
Yoshitomo Maesako, Takashi Uchiyama, Hitoshi Ohno;
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145
Su-Bing Cao, Michael J. Strong, Xia Wang, Walter N. Moss, Monica Concha, Zhen Lin, Tina O'Grady, Melody Baddoo, Claire Fewell, Rolf Renne, Erik K. Flemington;
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; HTB-62
BCRJ; 0338
CLS; 302310
ECACC; 86010701
IZSLER; BS TCL 99
Cell line databases/resources CLO; CLO_0008282
CLO; CLO_0008331
CLDB; cl3837
CLDB; cl5159
CLDB; cl5242
cancercelllines; CVCL_2676
Cell_Model_Passport; SIDM01254
CGH-DB; 9199-4
DepMap; ACH-000707
IGRhCellID; P3HR1
LINCS_LDP; LCL-2024
Biological sample resources BioSample; SAMN10987599
CRISP screens repositories BioGRID_ORCS_Cell_line; 207
Chemistry resources ChEMBL-Cells; CHEMBL3307242
ChEMBL-Targets; CHEMBL612705
GDSC; 1330988
PharmacoDB; P3HR1_1234_2019
PubChem_Cell_line; CVCL_2676
Encyclopedic resources Wikidata; Q54937282
Experimental variables resources EFO; EFO_0002312
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2770
GEO; GSM887493
GEO; GSM888575
Polymorphism and mutation databases Cosmic; 724830
Cosmic; 1517661
Cosmic; 2808228
Cosmic; 2822951
IARC_TP53; 177
LiGeA; CCLE_098
Progenetix; CVCL_2676
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41