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Cellosaurus Jiyoye (CVCL_1317)

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Cell line name Jiyoye
Synonyms JIYOYE; Jijoye; JIJOYE; P-2003; P3 (Jiyoye); P-3-Jijoye; P3-Jiyoye; P-3J; P3J; Jiyoye(P-2003); Jiyoye (P-2003); JiyoyeP-2003; JIYOYEP2003; OB2; GM04678
Accession CVCL_1317
Resource Identification Initiative To cite this cell line use: Jiyoye (RRID:CVCL_1317)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: African; Nigerian.
Virology: Contains a complete EBV genome (strain Jiyoye) which has been sequenced (PubMed=25787276).
Doubling time: ~30-60 hours (DSMZ=ACC-590).
Microsatellite instability: Instable (MSI-low) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*03:01,74:01
HLA-BB*53:01,58:01
HLA-CC*04:01,04:01
Class II
HLA-DQDQA1*01:02,05:01
DQB1*03:01,06:02
HLA-DRDRB1*11:02,15:03

Source: CLS=300366
Class I
HLA-AA*03:01:01,74:01:01
HLA-BB*53:01:01,58:01:01
HLA-CC*04:01:01
Class II
HLA-DPDPB1*01:01:01,02:01:02
HLA-DQDQA1*01:02:01,05:05:01
DQB1*03:19:01,06:02:01
HLA-DRDRB1*11:02:01,15:03:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African92.69
Native American0
East Asian, North2.15
East Asian, South0
South Asian0
European, North0
European, South5.16
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1Q45 (F-137)CVCL_2516 (HS-Sultan)CVCL_2676 (P3HR-1)
CVCL_E9ZN (P3HR-5)CVCL_E9ZP (P3HR-7)CVCL_C5DK (sfJiyoye)
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-87; CLS=300366; Cosmic-CLP=907268; DSMZ=ACC-590; ECACC=88071302; IZSLER=BS TCL 32; KCLB=10087; PubMed=17254797

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133821
D3S135816,17
D5S81812
D7S8208,10
D8S117914,15
D13S31712
D16S5399,10 (PubMed=17254797)
10,11 (ATCC=CCL-87; CLS=300366; Cosmic-CLP=907268; DSMZ=ACC-590; ECACC=88071302; IZSLER=BS TCL 32; KCLB=10087)
D18S5112
D19S43312,15
D21S1127 (PubMed=17254797)
28,36 (ATCC=CCL-87; CLS=300366; DSMZ=ACC-590; IZSLER=BS TCL 32)
FGA23,24
Penta D2.2,12 (ATCC=CCL-87; CLS=300366)
3,12 (DSMZ=ACC-590)
Penta E8,12
TH017,9
TPOX6,8
vWA15,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=4169243; DOI=10.1093/jnci/39.5.1027
George Klein, Peter Clifford, Eva Klein, Richard T. Smith, Jun Minowada, Francois M. Kourilsky, Joseph Holland Burchenal;
Membrane immunofluorescence reactions of Burkitt lymphoma cells from biopsy specimens and tissue cultures.
J. Natl. Cancer Inst. 39:1027-1044(1967)

PubMed=6018567
Charles P. Miles, Frank O'Neill;
Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.
Cancer Res. 27:392-402(1967)

PubMed=4894370; DOI=10.1002/1097-0142(196908)24:2<211::AID-CNCR2820240202>3.0.CO;2-3
Chester Milton Southam, Joseph Holland Burchenal, Bayard Delafield Clarkson Sr., Adrienne Tanzi, Rosemary Mackey, Vivian McComb;
Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.
Cancer 24:211-222(1969)

PubMed=5260617; DOI=10.1093/jnci/43.5.1129
Chester C. Huang, Tatsuo Imamura, George Eugene Moore;
Chromosomes and cloning efficiencies of hematopoietic cell lines derived from patients with leukemia, melanoma, myeloma, and Burkitt lymphoma.
J. Natl. Cancer Inst. 43:1129-1146(1969)

PubMed=5786183; DOI=10.1128/JVI.3.5.525-527.1969; PMCID=PMC375804
Kenneth J. McCormick, Wayne Albert Stenback, John J. Trentin, George Klein, Jagadish S. Nadkarni, Jayshree Jagadish Nadkarni, Peter Clifford;
Complement-fixation test for detection of herpes-like viruses in cell cultures of Burkitt's lymphoma.
J. Virol. 3:525-527(1969)

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=4321017; DOI=10.1002/ijc.2910060315
Frederick E. Durr, James H. Monroe, Rene Schmitter, Karl A. Traul, Yashar Hirshaut;
Studies on the infectivity and cytopathology of Epstein-Barr virus in human lymphoblastoid cells.
Int. J. Cancer 6:436-449(1970)

PubMed=4321974
Bruce A. Maurer, Tatsuo Imamura, Sharon M. Wilbert;
Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt lymphoma cell lines.
Cancer Res. 30:2870-2875(1970)

PubMed=4736620; DOI=10.1111/j.1469-1809.1973.tb00588.x
Susan Povey, Susan Elizabeth Gardiner, B. Watson, Susan Mowbray, Harry Harris, Elizabeth Arthur, Christopher Michael Steel, Christine Blenkinsop, Henry Jones Evans;
Genetic studies on human lymphoblastoid lines: isozyme analysis on cell lines from forty-one different individuals and on mutants produced following exposure to a chemical mutagen.
Ann. Hum. Genet. 36:247-266(1973)

PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x
Susan Povey, Stephen Jeremiah, Elizabeth Arthur, Michael Steel, George Klein;
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Ann. Hum. Genet. 44:119-133(1980)

PubMed=6231253; DOI=10.1002/ijc.2910330407
Barbro Ehlin-Henriksson, George Klein;
Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.
Int. J. Cancer 33:459-463(1984)

PubMed=6500159; DOI=10.1159/000163283
Merrill Eric Gershwin, Daniel Lentz, Robert B. Owens;
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

PubMed=2998993
Christopher Michael Steel, John E.N. Morten, E. Foster;
The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.
IARC Sci. Publ. 60:265-292(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Barbro Ehlin-Henriksson, Agneta Manneborg-Sandlund, George Klein;
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x; PMCID=PMC452998
Paul J. Farrell, Gordon J. Allan, Frances Shanahan, Karen Heather Vousden, Tim Crook;
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

CLPUB00447
Richard A. Mulivor, Sharon F. Suchy;
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418
Vinay K. Jain, Jean-Gabriel Judde, Edward E. Max, Ian Trevor Magrath;
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=8108117
Thomas Albert, Birgit Urlbauer, Franz Kohlhuber, Bettina Hammersen, Dirk Eick;
Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines.
Oncogene 9:759-763(1994)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Ulf Klangby, Ismail Okan, Kristinn Petur Magnusson, Martin Wendland, Peter Lind, Klas G. Wiman;
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25787276; DOI=10.1128/JVI.03614-14; PMCID=PMC4442510
Anne L. Palser, Nicholas Edwin Grayson, Robert E. White, Craig Corton, Samantha Correia, Mohammed M. Ba Abdullah, Simon J. Watson, Matthew Cotten, John R. Arrand, Paul G. Murray, Martin John Allday ...Show all 15 authors... , Alan Bernard Rickinson, Lawrence S. Young, Paul J. Farrell, Paul Kellam; Show fewer authors
Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection.
J. Virol. 89:5222-5237(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CCL-87
ATCC; CRL-7933 - Discontinued
CLS; 300366
Coriell; GM04678
DSMZ; ACC-590
ECACC; 88071302
IZSLER; BS TCL 32
KCLB; 10087
NCBI_Iran; C117
Cell line databases/resources CLO; CLO_0007025
CLO; CLO_0019011
CLDB; cl2945
CLDB; cl2946
cancercelllines; CVCL_1317
Cell_Model_Passport; SIDM00808
Cosmic-CLP; 907268
DepMap; ACH-002252
DSMZCellDive; ACC-590
IGRhCellID; Jiyoye
LINCS_LDP; LCL-2021
Biological sample resources BioSample; SAMN01821570
BioSample; SAMN01821640
BioSample; SAMN03471289
CRISP screens repositories BioGRID_ORCS_Cell_line; 270
Chemistry resources ChEMBL-Cells; CHEMBL3307658
ChEMBL-Targets; CHEMBL614588
GDSC; 907268
PharmacoDB; Jiyoye_703_2019
PubChem_Cell_line; CVCL_1317
Encyclopedic resources Wikidata; Q54898929
Experimental variables resources EFO; EFO_0002215
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-3610
GEO; GSM1669960
Polymorphism and mutation databases Cosmic; 687846
Cosmic; 907268
Cosmic; 931105
Cosmic; 1818344
Cosmic; 2822950
IARC_TP53; 702
Progenetix; CVCL_1317
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number48