Cellosaurus cell line FF452-3 (CVCL

Cellosaurus FF452-3 (CVCL_IU56)

Cross-references
Cell line name	FF452-3
Synonyms	FF452 clone 3; HR-1 FF452 Cl3
Accession	CVCL_IU56
Resource Identification Initiative	To cite this cell line use: FF452-3 (RRID:CVCL_IU56)
Comments	Population: African; Nigerian. Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV). Derived from site: In situ; Ascites; UBERON=UBERON_0007795. Cell type: B-cell; CL=CL_0000236.
Sequence variations	Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163His (c.487T>C); ClinVar=VCV000376680; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu287Ter (c.859G>T); Zygosity=Unspecified (from parent cell line).
Disease	EBV-related Burkitt lymphoma (NCIt: C27694) Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_2676 (P3HR-1)
Sex of cell	Male
Age at sampling	7Y
Category	Cancer cell line
Publications	PubMed=6276755; DOI=10.1038/295160a0 Lee Heston, Michael Rabson, Nathaniel A. Brown, I. George Miller Jr.; New Epstein-Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma. Nature 295:160-163(1982) PubMed=6294333; DOI=10.1128/JVI.44.3.834-844.1982; PMCID=PMC256340 Michael Rabson, Lyndle Gradoville, Lee Heston, I. George Miller Jr.; Non-immortalizing P3J-HR-1 Epstein-Barr virus: a deletion mutant of its transforming parent, Jijoye. J. Virol. 44:834-844(1982) PubMed=6302703; DOI=10.1073/pnas.80.9.2762; PMCID=PMC393908 Michael Rabson, Lee Heston, I. George Miller Jr.; Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells. Proc. Natl. Acad. Sci. U.S.A. 80:2762-2766(1983)
Cell line databases/resources	cancercelllines; CVCL_IU56
Encyclopedic resources	Wikidata; Q54834774
Entry history
Entry creation	03-Mar-2017
Last entry update	27-Nov-2025
Version number	14