| Cell line name |
HRI +2 |
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| Synonyms |
HRI + 2 |
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| Accession |
CVCL_E4CV |
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| Resource Identification Initiative |
To cite this cell line use: HRI +2 (RRID:CVCL_E4CV) |
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| Comments |
Population: African; Nigerian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Miscellaneous: While this cell line was obtained by Benjamin, David from Gerber, Paul, there is no indication in how it differs from the parent cell line or even if it is identical to P3HR-1.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: B-cell; CL=CL_0000236. |
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| Sequence variations |
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163His (c.487T>C); ClinVar=VCV000376680; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu287Ter (c.859G>T); Zygosity=Unspecified (from parent cell line).
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| Disease |
EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2676 (P3HR-1) |
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| Sex of cell |
Male |
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| Age at sampling |
7Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=3100061; DOI=10.1016/0008-8749(86)90099-7
David Benjamin, Leonard S. Bazar, Brett Wallace, Robert J. Jacobson;
Heterogeneity of B-cell growth factor receptor reactivity in healthy donors and in patients with chronic lymphatic leukemia: relationship to B-cell-derived lymphokines.
Cell. Immunol. 103:394-408(1986) PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289
David Benjamin, Thomas J. Knobloch, Mark A. Dayton;
Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10.
Blood 80:1289-1298(1992) PubMed=8176200; DOI=10.4049/jimmunol.152.10.4749
David Benjamin, Venkatanarayanan Sharma, Thomas J. Knobloch, Richard J. Armitage, Mark A. Dayton, Raymond G. Goodwin;
B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.
J. Immunol. 152:4749-4757(1994) PubMed=8568269; DOI=10.4049/jimmunol.156.4.1626
David Benjamin, Venkatanarayanan Sharma, Marek Kubin, Jared L. Klein, Alexandrina Sartori, Jane Holliday, Giorgio Trinchieri;
IL-12 expression in AIDS-related lymphoma B cell lines.
J. Immunol. 156:1626-1637(1996) |
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| Entry history |
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| Entry creation | 19-Dec-2024 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 1 |
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