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Cellosaurus TDL-1 (CVCL_8428)

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Cell line name TDL-1
Accession CVCL_8428
Resource Identification Initiative To cite this cell line use: TDL-1 (RRID:CVCL_8428)
Comments Problematic cell line: Contaminated. Shown to be a P3HR-1 derivative (PubMed=6248453; PubMed=20143388). Originally thought to be a tonsillar lymphoid cell line from a male patient with recurrent exudative tonsillitis.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00097.
Population: African; Nigerian.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr163His (c.487T>C); ClinVar=VCV000376680; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu287Ter (c.859G>T); Zygosity=Unspecified (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2676 (P3HR-1)
Sex of cell Male
Age at sampling 7Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=6248453; DOI=10.1007/BF02618368
Betty R. Conner, Soldano Ferrone, Michele A. Pellegrino, Ronald Glaser;
Lymphoid cell line identification and the detection of cross contamination.
In Vitro 16:446-452(1980)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8428
Biological sample resources BioSample; SAMN03151883
Encyclopedic resources Wikidata; Q54971922
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27