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Cellosaurus L1210 (CVCL_0382)

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Cell line name L1210
Synonyms L 1210; L-1210; Leukemic 1210; Leukemia 1210; Leukemia L1210
Accession CVCL_0382
Resource Identification Initiative To cite this cell line use: L1210 (RRID:CVCL_0382)
Comments Part of: ENCODE project mouse cell lines.
Characteristics: Used for the initial screening of antitumor agents. Its sensitivity to the majority of clinically useful antitumor drugs makes it a potentially suitable model for detailed studies of the mechanisms of action of these drugs (PubMed=6850600).
Doubling time: 10-12 hours (CLS=400257); ~50 hours (DSMZ=ACC-123).
Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: T-cell; CL=CL_0000084.
Disease Mouse leukemia (NCIt: C21604)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Children:
CVCL_C8R6 (L1210 dGuo-R)CVCL_IM26 (L1210 HHT)CVCL_F929 (L1210 TGR3)
CVCL_C511 (L1210 TGR4)CVCL_E9WK (L1210-46.1)CVCL_E9WL (L1210-56.3)
CVCL_C513 (L1210-5FU-R-TC)CVCL_H699 (L1210-6MP-R-TC)CVCL_Y418 (L1210/0)
CVCL_E2YE (L1210/6MP)CVCL_E2YF (L1210/6TG)CVCL_R996 (L1210/Ara-C)
CVCL_4Y57 (L1210/CPA)CVCL_1B40 (L1210/DDP)CVCL_Y421 (L1210/DDP2)
CVCL_Y422 (L1210/DDP5)CVCL_4V14 (L1210/PtR4)CVCL_N029 (L1210/R71)
CVCL_N028 (L1210/R81)CVCL_4Y62 (L1210/TZR)CVCL_C8R8 (L1210/VMDRC.06)
CVCL_Y424 (L1210:RD1694)CVCL_B7N4 (MTA-13)
Sex of cell Female
Age at sampling 8M
Category Cancer cell line
STR profile Source(s): PubMed=31220119

Markers:
Mouse STR 1-115,17
Mouse STR 1-216
Mouse STR 2-115
Mouse STR 3-213
Mouse STR 4-220.3
Mouse STR 5-513
Mouse STR 6-417
Mouse STR 6-712
Mouse STR 7-127,28
Mouse STR 8-116
Mouse STR 11-217
Mouse STR 12-116
Mouse STR 13-117
Mouse STR 15-321.3,22.3
Mouse STR 17-216
Mouse STR 18-316,17
Mouse STR 19-212
Mouse STR X-127

Run an STR similarity search on this cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-479.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/L1210_cells
Publications

PubMed=13804596
Robert Wallace Brockman;
A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms.
Cancer Res. 20:643-653(1960)

PubMed=18630317; DOI=10.1093/jnci/36.3.405
George Eugene Moore, Avery Aba Sandberg, Kay Ulrich;
Suspension cell culture and in vivo and in vitro chromosome constitution of mouse leukemia L1210.
J. Natl. Cancer Inst. 36:405-421(1966)

PubMed=6970130; DOI=10.1002/eji.1830101111
Andreas Conzelmann, J. Richard L. Pink, Oreste Acuto, Jean-Pierre Mach, Souzan Dolivo, Markus Nabholz;
Presence of T 145 on cytolytic T cell lines and their lectin-resistant mutants.
Eur. J. Immunol. 10:860-868(1980)

PubMed=6182115; DOI=10.1002/ijc.2910300317
Richard L. Momparler, Louise Farley Momparler, Johanne Samson;
Combinational chemotherapy of L1210 and L1210/ARA-C leukemia with 5-AZA-2'-deoxycytidine and beta-2'-deoxythioguanosine.
Int. J. Cancer 30:361-364(1982)

PubMed=6890814; DOI=10.1016/0006-2952(82)90096-x
Janna Diane Strobel-Stevens, Salah M. El Dareer, Mary W. Trader, Donald L. Hill;
Some biochemical characteristics of L1210 cell lines resistant to 6-mercaptopurine and 6-thioguanine and with increased sensitivity to methotrexate.
Biochem. Pharmacol. 31:3133-3137(1982)

PubMed=6850600
Marjoleine Brouwer, Lou A. Smets, Ans P.M. Jongsma;
Isolation and characterization of subclones of L1210 murine leukemia with different sensitivities to various cytotoxic agents.
Cancer Res. 43:2884-2888(1983)

PubMed=25277546; DOI=10.1186/1471-2164-15-847; PMCID=PMC4198738
John Paul Didion, Ryan J. Buus, Zohreh Naghashfar, David W. Threadgill, Herbert Carpenter Morse 3rd, Fernando Pardo-Manuel de Villena;
SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.
BMC Genomics 15:847.1-847.11(2014)

PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308
Jamie L. Almeida, Aleksandra Dakic, Karin Kindig, Maikan Kone, Deborah Lee Dormady Letham, Scott Langdon, Ruth Peat, Jayamalini Holding-Pillai, Erin M. Hall, Mark Ladd, Megan D. Shaffer, Heath Berg, Jin-Liang Li ...Show all 23 authors... , Georges Wigger, Steve Lund, Carolyn R. Steffen, Barbara B. Fransway, Bob Geraghty, Manuela Natoli, Beth A. Bauer, Susanne M. Gollin, Dale W. Lewis, Yvonne A. Reid; Show fewer authors
Interlaboratory study to validate a STR profiling method for intraspecies identification of mouse cell lines.
PLoS ONE 14:e0218412.1-e0218412.24(2019)

Cross-references
Cell line collections (Providers) ATCC; CCL-219
BCRC; 60049
BCRJ; 0138
CCTCC; GDC0203
CLS; 400257 - Discontinued
DSMZ; ACC-123
ECACC; 87092804
ICLC; ATL99002
IZSLER; BS TCL 152
JCRB; JCRB9026
KCB; KCB 200774YJ
KCLB; 10219
TKG; TKG 0154
Cell line databases/resources CLO; CLO_0007139
CLO; CLO_0007155
CLO; CLO_0007156
MCCL; MCC:0000277
CLDB; cl3111
CLDB; cl3112
CLDB; cl3113
CLDB; cl3114
CLDB; cl3115
CLDB; cl4936
CLDB; cl5219
CCRID; 1101MOU-PUMC000191
CCRID; 3101MOUTCM22
CCRID; 4201MOU-CCTCC00203
CCRID; 6101MOU-CERC000108
DSMZCellDive; ACC-123
Anatomy/cell type resources BTO; BTO_0000702
Biological sample resources BioSample; SAMN11397625
ENCODE; ENCBS116ENC
Chemistry resources ChEMBL-Cells; CHEMBL3308391
ChEMBL-Targets; CHEMBL386
PubChem_Cell_line; CVCL_0382
Encyclopedic resources Wikidata; Q6456824
Experimental variables resources EFO; EFO_0005284
Gene expression databases GEO; GSM1112425
GEO; GSM1112426
Medical resources MeSH; D007939
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number34