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Cellosaurus L1210/DDP5 (CVCL_Y422)

[Text version]

Cell line name L1210/DDP5
Synonyms L1210(DDP5); L1210 (DDP5); L1210DDP5
Accession CVCL_Y422
Resource Identification Initiative To cite this cell line use: L1210/DDP5 (RRID:CVCL_Y422)
Comments Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Derived from sampling site: Ascites.
Disease Mouse leukemia (NCIt: C21604)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Parent: CVCL_0382 (L1210)
Sex of cell Female
Age at sampling 8M
Category Cancer cell line

Eastman A., Illenye S.
Murine leukemia L1210 cell lines with different patterns of resistance to platinum coordination complexes.
Cancer Treat. Rep. 68:1189-1190(1984)

Richon V.M., Schulte N., Eastman A.
Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.
Cancer Res. 47:2056-2061(1987)

PubMed=3167012; DOI=10.1021/bi00413a022
Eastman A., Schulte N.
Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II).
Biochemistry 27:4730-4734(1988)

Kraker A.J., Moore C.W.
Accumulation of cis-diamminedichloroplatinum(II) and platinum analogues by platinum-resistant murine leukemia cells in vitro.
Cancer Res. 48:9-13(1988)

PubMed=1986276; DOI=10.1016/0921-8777(91)90044-P
Jennerwein M.M., Eastman A., Khokhar A.R.
The role of DNA repair in resistance of L1210 cells to isomeric 1,2-diaminocyclohexaneplatinum complexes and ultraviolet irradiation.
Mutat. Res. 254:89-96(1991)

PubMed=10200488; DOI=10.1038/sj.cdd.4400357
Segal-Bendirdjian E., Mannone L., Jacquemin-Sablon A.
Alteration in p53 pathway and defect in apoptosis contribute independently to cisplatin-resistance.
Cell Death Differ. 5:390-400(1998)

Chemistry resources ChEMBL-Cells; CHEMBL3307477
ChEMBL-Targets; CHEMBL613512
Encyclopedic resources Wikidata; Q54900962
Entry history
Entry creation07-Nov-2014
Last entry update02-Jul-2020
Version number9