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Cellosaurus INS-1 (CVCL_0352)

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Cell line name INS-1
Synonyms INS1
Accession CVCL_0352
Resource Identification Initiative To cite this cell line use: INS-1 (RRID:CVCL_0352)
Comments Characteristics: Established from the transplantable insulinoma RIN.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Children:
CVCL_F5PQ (EDITGENE INS-1-Cas9)CVCL_F6AM (EDITGENE INS-1-CopGFP)CVCL_F5SX (EDITGENE INS-1-FLUC)
CVCL_WH61 (GRINCH)CVCL_F1QZ (HyCyte INS-1 KO-rAbcc8)CVCL_E1LG (HyCyte INS-1 KO-rHnf1a)
CVCL_E1LH (HyCyte INS-1 KO-rHnf4a)CVCL_E1LI (HyCyte INS-1 KO-rIer3ip1)CVCL_F1R0 (HyCyte INS-1 KO-rKcnj11)
CVCL_F1R1 (HyCyte INS-1 KO-rPax4)CVCL_E1LJ (HyCyte INS-1 KO-rSsr1)CVCL_F1R2 (HyCyte INS-1 KO-rSting1)
CVCL_F4HE (HyCyte INS-1 KO-rWFS1)CVCL_F4LW (HyCyte INS-1 stable cell line for rAbcc8 overexpression)CVCL_EG57 (INS-1 832/1)
CVCL_7226 (INS-1 832/13)CVCL_EG56 (INS-1 832/2)CVCL_ZL55 (INS-1 832/3)
CVCL_2G79 (INS-1 833/117)CVCL_2G78 (INS-1 833/15)CVCL_2G77 (INS-1 834/40)
CVCL_0351 (INS-1E)CVCL_W945 (INS-r3)
Originate from same individual CVCL_J993 ! INS-2
CVCL_3584 ! RIN-m
CVCL_D163 ! RIN-r
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Web pages Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/i/cell-lines-detail-31.html
Publications

PubMed=1370150; DOI=10.1210/endo.130.1.1370150
Maryam Asfari, Danilo Janjic, Paolo Meda, Guo-Dong Li, Philippe Alexandre Halban, Claes Benedict Wollheim;
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.
Endocrinology 130:167-178(1992)

PubMed=8697299
Vincent Poitout, Lawrence Karl Olson, R. Paul Robertson;
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

PubMed=36180704; DOI=10.1007/978-1-0716-2593-4_35
Juliane Zibolka, Ina Bahr, Elmar Peschke, Eckhard Muhlbauer, Ivonne Bazwinsky-Wutschke;
Human and rodent cell lines as models of functional melatonin-responsive pancreatic islet cells.
Methods Mol. Biol. 2550:329-352(2022)

Cross-references
Cell line collections (Providers) AddexBio; C0018007/371
CLS; 300471
EDITGENE; EDC00182
KCB; KCB 2010005YJ
Cell line databases/resources MCCL; MCC:0000246
CCRID; 1101RAT-PUMC000378
Lonza; 301
TOKU-E; 3996
Anatomy/cell type resources BTO; BTO_0002135
Chemistry resources ChEMBL-Cells; CHEMBL3308040
ChEMBL-Targets; CHEMBL613545
PubChem_Cell_line; CVCL_0352
Encyclopedic resources Wikidata; Q54897741
Experimental variables resources EFO; EFO_0002529
Proteomic databases PRIDE; PXD013232
Entry history
Entry creation04-Apr-2012
Last entry update25-Jun-2026
Version number27