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Cellosaurus GRINCH (CVCL_WH61)

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Cell line name GRINCH
Synonyms Glucose-Responsive INsulin-secreting C-peptide-modified Human-proinsulin
Accession CVCL_WH61
Resource Identification Initiative To cite this cell line use: GRINCH (RRID:CVCL_WH61)
Comments Characteristics: Transfected with the hPro-CpepSfGFP construct containing human insulin with a C-peptide modified with a C-terminal Superfolder GFP insert.
Genetic integration: Method=Transfection; Gene=FPbase; B4SOW; Superfolder GFP (Note=sfGFP, superfolding variant of GFP).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Parent: CVCL_0352 (INS-1)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=23223446; DOI=10.1074/jbc.M112.420018; PMCID=PMC3548498
Leena Haataja, Erik Snapp, Jordan Wright, Ming Liu, Alexandre B. Hardy, Michael B. Wheeler, Michele L. Markwardt, Mark Rizzo, Peter Arvan;
Proinsulin intermolecular interactions during secretory trafficking in pancreatic beta cells.
J. Biol. Chem. 288:1896-1906(2013)

CLPUB00488
Jalal Taneera, Leena Haataja, Claes Benedict Wollheim, Leif Christer Groop;
FTO silencing inhibits insulin secretion in GRINCH cells: a new pancreatic beta cell line tool for beta cell function.
(In conference) Abstracts of EASD virtual meeting; pp.AB338-AB338; European Association for the Study of Diabetes; Dusseldorf; Germany (2016)

Cross-references
Encyclopedic resources Wikidata; Q93934841
Entry history
Entry creation24-May-2019
Last entry update10-Apr-2025
Version number7