Cellosaurus GRINCH (CVCL_WH61)
Cell line name | GRINCH |
---|---|
Synonyms | Glucose-Responsive INsulin-secreting C-peptide-modified Human-proinsulin |
Accession | CVCL_WH61 |
Resource Identification Initiative | To cite this cell line use: GRINCH (RRID:CVCL_WH61) |
Comments | Characteristics: Transfected with the hPro-CpepSfGFP construct containing human insulin with a C-peptide modified with a C-terminal superfolderGFP insert. Transfected with: HGNC; 6081; INS. Transfected with: UniProtKB; P42212; GFP (with p.Ser30Arg, p.Tyr39Asn, p.Phe64Leu, p.Ser65Thr, p.Gln80Arg, p.Phe99Ser, p.Asn105Thr, p.Tyr145Phe, p.Met153Thr, p.Val163Ala, p.Ile171Val and p.Ala206Val = SuperfolderGFP). Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169. |
Disease | Rat insulinoma (NCIt: C121566) |
Species of origin | Rattus norvegicus (Rat)
(NCBI Taxonomy: 10116)
Breed/subspecies: NEDH. |
Hierarchy | Parent: CVCL_0352 (INS-1) |
Sex of cell | Male |
Age at sampling | 666D |
Category | Cancer cell line |
Publications | PubMed=23223446; DOI=10.1074/jbc.M112.420018 CLPUB00488 |
Cross-references | |
Encyclopedic resources | Wikidata; Q93934841 |
Entry history | |
Entry creation | 24-May-2019 |
Last entry update | 29-Jun-2023 |
Version number | 4 |