| Publication number |
CLPUB00488 |
|---|
| Authors |
Taneera J., Haataja L., Wollheim C.B., Groop L.C. |
|---|
| Title |
FTO silencing inhibits insulin secretion in GRINCH cells: a new pancreatic beta cell line tool for beta cell function. |
|---|
| Citation |
(In) Abstracts of EASD virtual meeting; pp.AB338-AB338; EASD; Munich (2016) |
|---|
| Web pages |
https://www.easd.org/virtualmeeting/home.html#!resources/fto-silencing-inhibits-insulin-secretion-in-grinch-cells-a-new-pancreatic-beta-cell-line-tool-for-beta-cell-function |
|---|
| Abstract |
FTO (Fat mass and obesity-associated) has been identified as an obesity-
susceptibility gene, which is strongly associated with increased risk of
obesity. A recent study showed that the FTO gene product has a rapid
turnover in pancreatic beta cells and affects the regulation of insulin
secretion under glucose stimulation. However, the functional role and
molecular mechanisms of FTO in pancreatic beta cells is still unclear. In
this study, we aim to investigate the role of FTO in the pancreatic beta
cells using a new pancreatic beta cell line tool for beta cell function
called GRINCH cells (Glucose-Responsive Insulin-secreting C-peptide-
modified Human-proinsulin).
|
|---|
| Cell lines |
CVCL_WH61; GRINCH |
|---|
