ID   GRINCH
AC   CVCL_WH61
SY   Glucose-Responsive INsulin-secreting C-peptide-modified Human-proinsulin
DR   Wikidata; Q93934841
RX   CelloPub=CLPUB00488;
RX   PubMed=23223446;
CC   Characteristics: Transfected with the hPro-CpepSfGFP construct containing human insulin with a C-peptide modified with a C-terminal Superfolder GFP insert.
CC   Genetic integration: Method=Transfection; Gene=FPbase; B4SOW; Superfolder GFP (Note=sfGFP, superfolding variant of GFP).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6081; INS.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH; RS=RS_0000603.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0352 ! INS-1
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 10-04-25; Version: 7
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RX   CelloPub=CLPUB00488;
RA   Taneera J., Haataja L., Wollheim C.B., Groop L.C.;
RT   "FTO silencing inhibits insulin secretion in GRINCH cells: a new
RT   pancreatic beta cell line tool for beta cell function.";
RL   (In conference) Abstracts of EASD virtual meeting; pp.AB338-AB338; European Association for the Study of Diabetes; Dusseldorf; Germany (2016).
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RX   PubMed=23223446; DOI=10.1074/jbc.M112.420018; PMCID=PMC3548498;
RA   Haataja L., Snapp E., Wright J., Liu M., Hardy A.B., Wheeler M.B.,
RA   Markwardt M.L., Rizzo M., Arvan P.;
RT   "Proinsulin intermolecular interactions during secretory trafficking
RT   in pancreatic beta cells.";
RL   J. Biol. Chem. 288:1896-1906(2013).
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