ID   GRINCH
AC   CVCL_WH61
SY   Glucose-Responsive INsulin-secreting C-peptide-modified Human-proinsulin
DR   Wikidata; Q93934841
RX   CelloPub=CLPUB00488;
RX   PubMed=23223446;
CC   Characteristics: Transfected with the hPro-CpepSfGFP construct containing human insulin with a C-peptide modified with a C-terminal superfolderGFP insert.
CC   Transfected with: HGNC; 6081; INS.
CC   Transfected with: UniProtKB; P42212; GFP (with p.Ser30Arg, p.Tyr39Asn, p.Phe64Leu, p.Ser65Thr, p.Gln80Arg, p.Phe99Ser, p.Asn105Thr, p.Tyr145Phe, p.Met153Thr, p.Val163Ala, p.Ile171Val and p.Ala206Val = SuperfolderGFP).
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0352 ! INS-1
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 29-06-23; Version: 4
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RX   CelloPub=CLPUB00488;
RA   Taneera J., Haataja L., Wollheim C.B., Groop L.C.;
RT   "FTO silencing inhibits insulin secretion in GRINCH cells: a new
RT   pancreatic beta cell line tool for beta cell function.";
RL   (In) Abstracts of EASD virtual meeting; pp.AB338-AB338; EASD; Munich (2016).
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RX   PubMed=23223446; DOI=10.1074/jbc.M112.420018;
RA   Haataja L., Snapp E., Wright J., Liu M., Hardy A.B., Wheeler M.B.,
RA   Markwardt M.L., Rizzo M., Arvan P.;
RT   "Proinsulin intermolecular interactions during secretory trafficking
RT   in pancreatic beta cells.";
RL   J. Biol. Chem. 288:1896-1906(2013).
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