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Cellosaurus RIN-m (CVCL_3584)

[Text version]
Cell line name RIN-m
Synonyms RINm
Accession CVCL_3584
Resource Identification Initiative To cite this cell line use: RIN-m (RRID:CVCL_3584)
Comments Characteristics: Established from the transplantable insulinoma RIN.
Characteristics: Secretes insulin and somatostatin (PubMed=6106192; PubMed=6141566).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Children:
CVCL_3583 (RIN-14B)CVCL_0501 (RIN-m5F)
Originate from same individual CVCL_0352 ! INS-1
CVCL_J993 ! INS-2
CVCL_D163 ! RIN-r
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=6106192; DOI=10.1073/pnas.77.6.3519; PMCID=PMC349648
Adi F. Gazdar, William L. Chick, Herbert Kazuto Oie, Harvie L. Sims, Dennis L. King, Gordon C. Weir, Vilma Lauris;
Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.
Proc. Natl. Acad. Sci. U.S.A. 77:3519-3523(1980)

PubMed=6295859; DOI=10.2337/diab.31.6.521
Sam J. Bhathena, Herbert Kazuto Oie, Adi F. Gazdar, Nancy R. Voyles, Samuel D. Wilkins, Lillian Recant;
Insulin, glucagon, and somatostatin receptors on cultured cells and clones from rat islet cell tumor.
Diabetes 31:521-531(1982)

PubMed=6129963; DOI=10.1210/endo-112-3-1070
Herbert Kazuto Oie, Adi F. Gazdar, John D. Minna, Gordon C. Weir, Stephen Bruce Baylin;
Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor.
Endocrinology 112:1070-1075(1983)

PubMed=6141566; DOI=10.3181/00379727-175-41762
Sam J. Bhathena, Sissay Awoke, Nancy R. Voyles, Samuel D. Wilkins, Lillian Recant, Herbert Kazuto Oie, Adi F. Gazdar;
Insulin, glucagon, and somatostatin secretion by cultured rat islet cell tumor and its clones.
Proc. Soc. Exp. Biol. Med. 175:35-38(1984)

PubMed=8697299
Vincent Poitout, Lawrence Karl Olson, R. Paul Robertson;
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

PubMed=8806089; DOI=10.1002/jcb.240630502
Adi F. Gazdar, John D. Minna;
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

Cross-references
Cell line collections (Providers) ATCC; CRL-2057
ECACC; 95071701
Cell line databases/resources CLO; CLO_0008818
CLDB; cl4151
Encyclopedic resources Wikidata; Q54950480
Experimental variables resources EFO; EFO_0022764
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number16