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Cellosaurus RIN-m5F (CVCL_0501)

[Text version]
Cell line name RIN-m5F
Synonyms RIN m5F; Rin-M-5F; Rin-m-5F; RIN-m 5F; RINm-5F; RINm5F; RIN-m clone 5F; RIN Cl-5F; RIN-5F; Rin-5F; RIN 5F; RIN5F; m5F; 5F
Accession CVCL_0501
Secondary accession CVCL_2177
Resource Identification Initiative To cite this cell line use: RIN-m5F (RRID:CVCL_0501)
Comments Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11605.
Characteristics: Secretes mainly insulin and little somatostatin (PubMed=6141566; PubMed=6295859).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Parent: CVCL_3584 (RIN-m)
Children:
CVCL_6811 (BRIN-BD11)CVCL_W093 (BRIN-BG5)CVCL_W094 (BRIN-BG7)
CVCL_0500 (RIN-5AH)CVCL_5T79 (RIN-5F-Bcl-2)CVCL_5T80 (RIN-5F-CrmA)
CVCL_D164 (RIN-A12)CVCL_D165 (RIN-A13)CVCL_A7QC (RIN-AhGh)
CVCL_A7QD (RIN-AhLh)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=RINm5F
Publications

PubMed=6295859; DOI=10.2337/diab.31.6.521
Sam J. Bhathena, Herbert Kazuto Oie, Adi F. Gazdar, Nancy R. Voyles, Samuel D. Wilkins, Lillian Recant;
Insulin, glucagon, and somatostatin receptors on cultured cells and clones from rat islet cell tumor.
Diabetes 31:521-531(1982)

PubMed=6129963; DOI=10.1210/endo-112-3-1070
Herbert Kazuto Oie, Adi F. Gazdar, John D. Minna, Gordon C. Weir, Stephen Bruce Baylin;
Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor.
Endocrinology 112:1070-1075(1983)

PubMed=6141566; DOI=10.3181/00379727-175-41762
Sam J. Bhathena, Sissay Awoke, Nancy R. Voyles, Samuel D. Wilkins, Lillian Recant, Herbert Kazuto Oie, Adi F. Gazdar;
Insulin, glucagon, and somatostatin secretion by cultured rat islet cell tumor and its clones.
Proc. Soc. Exp. Biol. Med. 175:35-38(1984)

PubMed=2550270; DOI=10.1055/s-0029-1210869
Jens Hoiriis Nielsen;
Mechanisms of pancreatic beta-cell growth and regeneration: studies on rat insulinoma cells.
Exp. Clin. Endocrinol. 93:277-285(1989)

PubMed=2569024; DOI=10.1677/joe.0.1210479
David George Lambert, Terence William Atkins;
Effects of islet hormones on insulin secretion from cloned B cell lines, HIT-T15 and RINm5F.
J. Endocrinol. 121:479-485(1989)

PubMed=2090331; DOI=10.1016/0922-3371(90)90097-G
Raphael K. Bartholomeusz, Iain L. Campbell, Leonard Charles Harrison;
A2B5-reactive ganglioside expression determines the differentiation stage and capacity of rat insulinoma (RIN) sublines.
Cell Differ. Dev. 32:39-46(1990)

PubMed=2156672; DOI=10.1210/endo-126-4-1927
Raphael K. Bartholomeusz, Iain L. Campbell, Leonard Charles Harrison;
A2B5-reactive ganglioside expression is an index of differentiation in rat insulinoma (RIN) cells.
Endocrinology 126:1927-1933(1990)

PubMed=8697299
Vincent Poitout, Lawrence Karl Olson, R. Paul Robertson;
Insulin-secreting cell lines: classification, characteristics and potential applications.
Diabetes Metab. 22:7-14(1996)

PubMed=10417352; DOI=10.1042/bj3410847; PMCID=PMC1220426
Carolyn Ewen Fiskerstrand, Paul Newey, Bahram Ebrahimi, Lesley Gerrard, Patrick Harrison, Gerard P. McGregor, John P. Quinn;
Novel cell lines for the analysis of preprotachykinin A gene expression identify a repressor domain 3' of the major transcriptional start site.
Biochem. J. 341:847-852(1999)

DOI=10.1016/j.bej.2003.09.013
Akiko Ogawa, Satoshi Terada, Yasuyuki Saito, Toshihisa Kimura, Akio Yamaguchi, Masao Miki;
CrmA and Bcl-2 protect a cell line derived from islet of Langerhans, RIN-5F from hypoxia-induced apoptosis.
Biochem. Eng. J. 20:209-215(2004)

PubMed=22538498; DOI=10.1159/000338793
Simona Grozinsky-Glasberg, Ilan Shimon, Hadara Rubinfeld;
The role of cell lines in the study of neuroendocrine tumors.
Neuroendocrinology 96:173-187(2012)

Cross-references
Cell line collections (Providers) ATCC; CRL-2058
ATCC; CRL-11605
BCRC; 60410
CCTCC; GDC0223
ECACC; 95090402
IBRC; C10101
NCBI_Iran; C526
Cell line databases/resources CLO; CLO_0008817
CLO; CLO_0008819
MCCL; MCC:0000398
CLDB; cl4150
CCRID; 1101RAT-PUMC000386
CCRID; 4201RAT-CCTCC00223
Lonza; 1056
Anatomy/cell type resources BTO; BTO_0001185
Encyclopedic resources Wikidata; Q54950473
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24