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Cellosaurus RIN-14B (CVCL_3583)

[Text version]
Cell line name RIN-14B
Synonyms Rin-14B; RIN14B; Rin14B; RIN-m 14B; RIN-m clone 14B; 14B
Accession CVCL_3583
Resource Identification Initiative To cite this cell line use: RIN-14B (RRID:CVCL_3583)
Comments Characteristics: Produces somatostatin and aromatic-L-amino-acid decarboxylase (DDC). Secretes insulin but at lower level than the parent cell line (PubMed=6141566; PubMed=6295859).
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic delta cell; CL=CL_0000173.
Disease Rat insulinoma (NCIt: C121566)
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy Parent: CVCL_3584 (RIN-m)
Sex of cell Male
Age at sampling 666D
Category Cancer cell line
Publications

PubMed=6295859; DOI=10.2337/diab.31.6.521
Sam J. Bhathena, Herbert Kazuto Oie, Adi F. Gazdar, Nancy R. Voyles, Samuel D. Wilkins, Lillian Recant;
Insulin, glucagon, and somatostatin receptors on cultured cells and clones from rat islet cell tumor.
Diabetes 31:521-531(1982)

PubMed=6141566; DOI=10.3181/00379727-175-41762
Sam J. Bhathena, Sissay Awoke, Nancy R. Voyles, Samuel D. Wilkins, Lillian Recant, Herbert Kazuto Oie, Adi F. Gazdar;
Insulin, glucagon, and somatostatin secretion by cultured rat islet cell tumor and its clones.
Proc. Soc. Exp. Biol. Med. 175:35-38(1984)

PubMed=1847683; DOI=10.1111/j.1432-1033.1991.tb15726.x
Brigitte Amiranoff, Anne-Marie Lorinet, Marc Laburthe;
A clonal rat pancreatic delta cell line (Rin14B) expresses a high number of galanin receptors negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway.
Eur. J. Biochem. 195:459-463(1991)

PubMed=9271225; DOI=10.1016/S0014-5793(97)00723-0
Robert Branstrom, Anders Hoog, Martin A. Wahl, Per-Olof Berggren, Olof Larsson;
RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin.
FEBS Lett. 411:301-307(1997)

Cross-references
Cell line collections (Providers) AddexBio; C0018020/5022
ATCC; CRL-2059
Cell line databases/resources CLO; CLO_0008816
Encyclopedic resources Wikidata; Q54950470
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number16