ID   RIN-14B
AC   CVCL_3583
SY   Rin-14B; RIN14B; Rin14B; RIN-m 14B; RIN-m clone 14B; 14B
DR   CLO; CLO_0008816
DR   AddexBio; C0018020/5022
DR   ATCC; CRL-2059
DR   Wikidata; Q54950470
RX   PubMed=1847683;
RX   PubMed=6141566;
RX   PubMed=6295859;
RX   PubMed=9271225;
CC   Characteristics: Produces somatostatin and aromatic-L-amino-acid decarboxylase (DDC). Secretes insulin but at lower level than the parent cell line (PubMed=6141566; PubMed=6295859).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic delta cell; CL=CL_0000173.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_3584 ! RIN-m
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 14
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RX   PubMed=1847683; DOI=10.1111/j.1432-1033.1991.tb15726.x;
RA   Amiranoff B., Lorinet A.-M., Laburthe M.;
RT   "A clonal rat pancreatic delta cell line (Rin14B) expresses a high
RT   number of galanin receptors negatively coupled to a
RT   pertussis-toxin-sensitive cAMP-production pathway.";
RL   Eur. J. Biochem. 195:459-463(1991).
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RX   PubMed=6141566; DOI=10.3181/00379727-175-41762;
RA   Bhathena S.J., Awoke S., Voyles N.R., Wilkins S.D., Recant L.,
RA   Oie H.K., Gazdar A.F.;
RT   "Insulin, glucagon, and somatostatin secretion by cultured rat islet
RT   cell tumor and its clones.";
RL   Proc. Soc. Exp. Biol. Med. 175:35-38(1984).
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RX   PubMed=6295859; DOI=10.2337/diab.31.6.521;
RA   Bhathena S.J., Oie H.K., Gazdar A.F., Voyles N.R., Wilkins S.D.,
RA   Recant L.;
RT   "Insulin, glucagon, and somatostatin receptors on cultured cells and
RT   clones from rat islet cell tumor.";
RL   Diabetes 31:521-531(1982).
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RX   PubMed=9271225; DOI=10.1016/S0014-5793(97)00723-0;
RA   Branstrom R., Hoog A., Wahl M.A., Berggren P.-O., Larsson O.;
RT   "RIN14B: a pancreatic delta-cell line that maintains functional
RT   ATP-dependent K+ channels and capability to secrete insulin under
RT   conditions where it no longer secretes somatostatin.";
RL   FEBS Lett. 411:301-307(1997).
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