Cellosaurus cell line INS-1 832/3 (CVCL

Cellosaurus INS-1 832/3 (CVCL_ZL55)

Cross-references
Cell line name	INS-1 832/3
Synonyms	INS-1 (832/3); 832/3
Accession	CVCL_ZL55
Resource Identification Initiative	To cite this cell line use: INS-1 832/3 (RRID:CVCL_ZL55)
Comments	Characteristics: Shows robust glucose-stimulated insulin secretion (GSIS) (Millipore=SCC208). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6081; INS. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCIt; C17262; X-Ray. Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease	Rat insulinoma (NCIt: C121566)
Species of origin	Rattus norvegicus (Rat) (NCBI Taxonomy: 10116) Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy	Parent: CVCL_0352 (INS-1)
Sex of cell	Male
Age at sampling	666D
Category	Cancer cell line
Publications	PubMed=10868964; DOI=10.2337/diabetes.49.3.424 Hans-Ewald Hohmeier, Hindrik Mulder, Guo-Xun Chen, Rosemarie Henkel-Rieger, Marc Prentki, Christopher Bang Newgard; Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 49:424-430(2000) PubMed=18755687; DOI=10.1074/jbc.M804665200; PMCID=PMC2570884 Sarah M. Ronnebaum, Mette V. Jensen, Hans-Ewald Hohmeier, Shawn C. Burgess, Yun-Ping Zhou, Su Qian, Douglas MacNeil, Andrew Howard, Nancy A. Thornberry, Olga Ilkayeva, Dan-Hong Lu ...Show all 13 authors... , A. Dean Sherry, Christopher Bang Newgard; Show fewer authors Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. J. Biol. Chem. 283:28909-28917(2008)
Cell line collections (Providers)	Millipore; SCC208
Encyclopedic resources	Wikidata; Q98126775
Entry history
Entry creation	02-Jul-2020
Last entry update	14-Aug-2025
Version number	10