Cellosaurus cell line INS-1E (CVCL

Cellosaurus INS-1E (CVCL_0351)

Cross-references
Cell line name	INS-1E
Synonyms	INS1-E; INS1E
Accession	CVCL_0351
Resource Identification Initiative	To cite this cell line use: INS-1E (RRID:CVCL_0351)
Comments	Characteristics: Used in numerous studies investigating the mechanisms of glucose stimulated insulin secretion. Is glucose responsive in a physiological range with substantial insulin content levels and a robust metabolism-secretion coupling (PubMed=30310992). Transformant: NCIt; C17262; X-Ray. Omics: Proteomics; Subcellular; Insulin secretory granules. Caution: This cell line is owned by the University of Geneva, Switzerland, who is the sole authorized distributor for both commercial and non-commercial research use. Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006. Cell type: Pancreatic beta cell; CL=CL_0000169.
Disease	Rat insulinoma (NCIt: C121566)
Species of origin	Rattus norvegicus (Rat) (NCBI Taxonomy: 10116) Breed/subspecies: NEDH; RS=RS_0000603.
Hierarchy	Parent: CVCL_0352 (INS-1)
Sex of cell	Male
Age at sampling	666D
Category	Cancer cell line
Web pages	Provider; Unitec; 739-A617; https://web.archive.org/web/20230331090632/https://www.unige.ch/unitec/files/9915/8470/0115/TechOffer739_INS-1E_cell_line.pdf
Publications	PubMed=14592952; DOI=10.1210/en.2003-1099 Arnaud Merglen, Sten Theander, Blanca Rubi, Gaelle Chaffard, Claes Benedict Wollheim, Pierre Maechler; Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology 145:667-678(2004) PubMed=22569486; DOI=10.1016/j.jprot.2012.04.023 Domitille Schvartz, Yannick Brunner, Yohann Coute, Michelangelo Foti, Claes Benedict Wollheim, Jean-Charles Sanchez; Improved characterization of the insulin secretory granule proteomes. J. Proteomics 75:4620-4631(2012) PubMed=30310992; DOI=10.1007/s00424-018-2215-z Marina Casimir, Gaelle Chaffard, Pierre Maechler; Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion. Pflugers Arch. 471:337-345(2019)
Cell line collections (Providers)	AddexBio; C0018009/4675 - Discontinued
Cell line databases/resources	MCCL; MCC:0000245 Lonza; 1137
Anatomy/cell type resources	BCGO; BCGO_0000120 BTO; BTO_0003317
Chemistry resources	ChEMBL-Cells; CHEMBL4651375 PubChem_Cell_line; CVCL_0351
Encyclopedic resources	Wikidata; Q54897749
Proteomic databases	PRIDE; PXD006544 PRIDE; PXD008988 PRIDE; PXD011329
Entry history
Entry creation	04-Apr-2012
Last entry update	14-Aug-2025
Version number	20