ID   INS-1E
AC   CVCL_0351
SY   INS1-E; INS1E
DR   BCGO; BCGO_0000120
DR   BTO; BTO:0003317
DR   MCCL; MCC:0000245
DR   AddexBio; C0018009/4675
DR   ChEMBL-Cells; CHEMBL4651375
DR   Lonza; 1137
DR   PRIDE; PXD006544
DR   PRIDE; PXD008988
DR   PRIDE; PXD011329
DR   PubChem_Cell_line; CVCL_0351
DR   Wikidata; Q54897749
RX   PubMed=14592952;
RX   PubMed=22569486;
RX   PubMed=30310992;
WW   https://www.unige.ch/unitec/files/9915/8470/0115/TechOffer739_INS-1E_cell_line.pdf
CC   Characteristics: Used in numerous studies investigating the mechanisms of glucose stimulated insulin secretion. Is glucose responsive in a physiological range with substantial insulin content levels and a robust metabolism-secretion coupling (PubMed=30310992).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Omics: Insulin secretory granules proteome analysis.
CC   Caution: This cell line is owned by the University of Geneva, Switzerland, who is the sole authorized distributor for both commercial and non-commercial research use.
CC   Discontinued: AddexBio; C0018009; true.
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
CC   Cell type: Pancreatic beta cell; CL=CL_0000169.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121566; Rat insulinoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0352 ! INS-1
SX   Male
AG   666D
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 16
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RX   PubMed=14592952; DOI=10.1210/en.2003-1099;
RA   Merglen A., Theander S., Rubi B., Chaffard G., Wollheim C.B.,
RA   Maechler P.;
RT   "Glucose sensitivity and metabolism-secretion coupling studied during
RT   two-year continuous culture in INS-1E insulinoma cells.";
RL   Endocrinology 145:667-678(2004).
//
RX   PubMed=22569486; DOI=10.1016/j.jprot.2012.04.023;
RA   Schvartz D., Brunner Y., Coute Y., Foti M., Wollheim C.B.,
RA   Sanchez J.-C.;
RT   "Improved characterization of the insulin secretory granule
RT   proteomes.";
RL   J. Proteomics 75:4620-4631(2012).
//
RX   PubMed=30310992; DOI=10.1007/s00424-018-2215-z;
RA   Casimir M., Chaffard G., Maechler P.;
RT   "Resveratrol long-term treatment differentiates INS-1E beta-cell
RT   towards improved glucose response and insulin secretion.";
RL   Pflugers Arch. 471:337-345(2019).
//