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Cellosaurus CCRF-CEM (CVCL_0207)

[Text version]
Cell line name CCRF-CEM
Synonyms CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C
Accession CVCL_0207
Resource Identification Initiative To cite this cell line use: CCRF-CEM (RRID:CVCL_0207)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Part of: NCI-60 cancer cell line panel.
Part of: NCI-7 clinical proteomics reference material cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8436.
Population: Caucasian.
Doubling time: 23 hours (PubMed=17117183); 24 hours (PubMed=20922763); 22.0 hours (PubMed=25070259); ~24 hours (CLS=300147); ~24-30 hours (DSMZ=ACC-240); 26.7 hours (NCI-DTP=CCRF-CEM).
Microsatellite instability: Instable (MSI-low) (PubMed=10739008; PubMed=11226526; PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Proteomics.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (PubMed=14500364; PubMed=17308084).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (PubMed=11565033; Cosmic-CLP=905952; DepMap=ACH-001738).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905952; DepMap=ACH-001738).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905952; DepMap=ACH-001738).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (PubMed=15472075).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (PubMed=2144611; PubMed=10071127; PubMed=17088437; Cosmic-CLP=905952; DepMap=ACH-001738).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=2144611; PubMed=9331090; PubMed=10071127; PubMed=17088437; Cosmic-CLP=905952; DepMap=ACH-001738).
HLA typing Source: PubMed=15748285
Class I
HLA-BB*08,40
HLA-CC*03:04:01,07
Class II
HLA-DPDPB1*04:01,13:01
HLA-DQDQB1*02:01,02:02
HLA-DRDRB1*03:01:01,07:01

Source: IPD-IMGT/HLA=10403
Class II
HLA-DPDPB1*04:01,13:01

Source: CLS=300147
Class I
HLA-AA*01:01:01,07:01:02
HLA-BB*08:01:01,16:01:02
HLA-CC*03:04:01,07:01:01
Class II
HLA-DPDPB1*04:01:01,13:XX
HLA-DQDQA1*02:01:01,05:01:01
DQB1*02:01:01,02:02:01
HLA-DRDRB1*03:01:01,07:01:01

Source: DSMZCellDive=ACC-240
Class I
HLA-AA*01:01:01,31:01:02
HLA-BB*08:01:01,40:01:02
HLA-CC*03:04:01,07:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.2
Native American0.21
East Asian, North0.43
East Asian, South0.09
South Asian0.81
European, North69.4
European, South28.85
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2265 (1301)CVCL_6869 (6T-CEM)CVCL_D101 (AG-F)
CVCL_GZ09 (ARAC-8C)CVCL_GZ10 (ARAC-8D)CVCL_G691 (BUC)
CVCL_B7A8 (CCRF-CEM C1)CVCL_6825 (CCRF-CEM C7)CVCL_V324 (CCRF-CEM R3/7)
CVCL_V323 (CCRF-CEM R30/6)CVCL_5H79 (CCRF-CEM/HU-R)CVCL_5H80 (CCRF-CEM/MTX R1)
CVCL_5H81 (CCRF-CEM/MTX R2)CVCL_5H82 (CCRF-CEM/MTX R3)CVCL_5H83 (CCRF-CEM/MTX140-LV)
CVCL_5H84 (CCRF-CEM/MTX1500-LV)CVCL_5H85 (CCRF-CEM/MTX5000-PGA)CVCL_5H86 (CCRF-CEM/MTX60-PGA)
CVCL_S649 (CCRF-CEM/R1)CVCL_S651 (CCRF-CEM/R3)CVCL_E7J2 (CCRF-CEM(Cas9))
CVCL_D545 (CCRF/ACTD400)CVCL_D544 (CCRF/ADR5000)CVCL_4V17 (CCRF/CEM/ara-C/3A)
CVCL_4V18 (CCRF/CEM/ara-C/7A)CVCL_A5TY (CCRF/CEM/ara-C/B)CVCL_A5UY (CCRF/CEM/ara-C/C)
CVCL_A5TZ (CCRF/CEM/ara-C/D)CVCL_A5UA (CCRF/CEM/ara-C/G)CVCL_A5UB (CCRF/CEM/ara-C/I)
CVCL_A5UC (CCRF/CEM/ara-C/J)CVCL_D546 (CCRF/VCR1000)CVCL_6244 (CEM A3.01)
CVCL_V186 (CEM cl13)CVCL_J396 (CEM-AGR)CVCL_X635 (CEM-CL10)
CVCL_3930 (CEM-CM3)CVCL_1G53 (CEM-GFP)CVCL_3931 (CEM-LAV-2)
CVCL_HF38 (CEM-R6)CVCL_J318 (CEM-SS)CVCL_8178 (CEM-T4)
CVCL_X697 (CEM-TART)CVCL_D598 (CEM-VBL16)CVCL_3933 (CEM-VCR R)
CVCL_4V08 (CEM-VLB)CVCL_X622 (CEM.NKR)CVCL_U260 (CEM/A5)
CVCL_U261 (CEM/A7)CVCL_4V21 (CEM/ara-C)CVCL_A5TX (CEM/ara-G)
CVCL_3496 (CEM/C1)CVCL_3497 (CEM/C2)CVCL_S256 (CEM/DNR)
CVCL_C3S2 (CEM/GN50)CVCL_0U11 (CEM/MX1)CVCL_A1BA (CEM/P)
CVCL_C5RY (CEM/VBL600)CVCL_D597 (CEM/VLB10)CVCL_3932 (CEM/VLB100)
CVCL_4V12 (CEM/VLB500)CVCL_4V09 (CEM/VLB55)CVCL_1B35 (CEM/VM-1)
CVCL_7905 (CEMR.3)CVCL_J653 (CO)CVCL_8865 (EU-7)
CVCL_E3H1 (HyCyte CCRF-CEM-Luc)CVCL_8265 (MKB-1)CVCL_L808 (RC-2A)
CVCL_GZ11 (TUB-4D)CVCL_8276 (UTMB-460)CVCL_A036 (WSU-ALCL)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): AddexBio=C0003001/32; ATCC=CCL-119; ATCC=CRL-8436; CLS=300147; Cosmic-CLP=905952; DSMZ=ACC-240; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB0033; JCRB=JCRB9023; KCLB=10119; PubMed=19372543; PubMed=20922763; RCB=RCB1980

Markers:
AmelogeninX
CSF1PO9,10,11 (RCB=RCB1980)
10,11 (AddexBio=C0003001/32; ATCC=CCL-119; Cosmic-CLP=905952; KCLB=10119; PubMed=20922763)
10,11,12 (JCRB=IFO50412; JCRB=JCRB9023)
10,13 (ATCC=CRL-8436; CLS=300147; DSMZ=ACC-240)
11 (ECACC=85112105; JCRB=JCRB0033; PubMed=19372543)
D2S133823,24 (DSMZ=ACC-240)
24 (ATCC=CCL-119; PubMed=19372543; PubMed=20922763)
D3S135814,15 (CLS=300147; DSMZ=ACC-240; KCLB=10119)
15 (ATCC=CCL-119; PubMed=19372543)
15,16 (PubMed=20922763)
D5S81812,13 (AddexBio=C0003001/32; ATCC=CCL-119; ATCC=CRL-8436; CLS=300147; DSMZ=ACC-240; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB0033; JCRB=JCRB9023; KCLB=10119; PubMed=19372543; PubMed=20922763; RCB=RCB1980)
12,13,14 (Cosmic-CLP=905952)
D7S8209,12 (JCRB=JCRB0033)
9,13 (AddexBio=C0003001/32; ATCC=CCL-119; ATCC=CRL-8436; CLS=300147; Cosmic-CLP=905952; DSMZ=ACC-240; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB9023; KCLB=10119; PubMed=19372543; PubMed=20922763; RCB=RCB1980)
D8S117912,13 (CLS=300147; DSMZ=ACC-240; PubMed=20922763)
13 (ATCC=CCL-119; PubMed=19372543)
D13S31710,11,12 (RCB=RCB1980)
11 (ATCC=CRL-8436; CLS=300147; DSMZ=ACC-240)
11,12 (AddexBio=C0003001/32; ATCC=CCL-119; Cosmic-CLP=905952; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB0033; JCRB=JCRB9023; KCLB=10119; PubMed=19372543; PubMed=20922763)
D16S53910,13 (AddexBio=C0003001/32; ATCC=CCL-119; ATCC=CRL-8436; CLS=300147; Cosmic-CLP=905952; DSMZ=ACC-240; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB0033; JCRB=JCRB9023; PubMed=19372543; PubMed=20922763)
10,13,14 (RCB=RCB1980)
D18S5113 (DSMZ=ACC-240)
13,18 (ATCC=CCL-119; CLS=300147)
D19S43314,15
D21S1130,33.2 (ATCC=CCL-119; PubMed=19372543; PubMed=20922763)
30,34.2 (CLS=300147; DSMZ=ACC-240)
FGA22,23,24,25 (DSMZ=ACC-240)
23,24 (ATCC=CCL-119; CLS=300147; PubMed=20922763)
24 (PubMed=19372543)
Penta D10,11 (CLS=300147; DSMZ=ACC-240)
11 (ATCC=CCL-119)
Penta E5 (DSMZ=ACC-240)
5,14 (ATCC=CCL-119; CLS=300147)
TH016,7
TPOX7,8 (DSMZ=ACC-240)
8 (AddexBio=C0003001/32; ATCC=CCL-119; ATCC=CRL-8436; CLS=300147; Cosmic-CLP=905952; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB0033; JCRB=JCRB9023; KCLB=10119; PubMed=19372543; PubMed=20922763; RCB=RCB1980)
vWA17,18,19 (DSMZ=ACC-240)
17,19 (AddexBio=C0003001/32; ATCC=CCL-119; ATCC=CRL-8436; CLS=300147; Cosmic-CLP=905952; ECACC=85112105; JCRB=IFO50412; JCRB=JCRB0033; JCRB=JCRB9023; KCLB=10119; PubMed=19372543; PubMed=20922763)
18,19 (RCB=RCB1980)

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/normal-morphology-of-atcc-ccl-119
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=29
Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/ccrf-cem/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-12.html
Provider; BRICS; BRICS0126; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3929
Provider; CCR; -; https://www.cccells.org/cellreqs-ncipptp.php
Provider; NIBSC; 0005; https://nibsc.org/Default.aspx?pageid=597&id=0005&theme=default
Publications

PubMed=14278051; DOI=10.1002/1097-0142(196504)18:4<522::AID-CNCR2820180418>3.0.CO;2-J
George E. Foley, Herbert Lazarus, Sidney Farber, Betty Geren Uzman, Barbara A. Boone, Robert E. McCarthy;
Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia.
Cancer 18:522-529(1965)

PubMed=5224274; DOI=10.1002/1097-0142(196611)19:11<1725::AID-CNCR2820191142>3.0.CO;2-T
Betty Geren Uzman, George E. Foley, Sidney Farber, Herbert Lazarus;
Morphologic variations in human leukemic lymphoblasts (CCRF-CEM cells) after long-term culture and exposure to chemotherapeutic agents. A study with the electron microscope.
Cancer 19:1725-1742(1966)

DOI=10.1007/BF02618370
Cyril S. Stulberg, Lewis Lemon Coriell, Alexis John Kniazeff, John E. Shannon;
The animal cell culture collection.
In Vitro 5:1-16(1970)

PubMed=4363409; DOI=10.1084/jem.139.5.1070; PMCID=PMC2139653
Joseph Kaplan, Thomas C. Shope, Ward Davis Peterson Jr.;
Epstein-Barr virus-negative human malignant T-cell lines.
J. Exp. Med. 139:1070-1076(1974)

PubMed=1086134
Joseph Kaplan, Ward Davis Peterson Jr.;
Detection of T-cell lymphoma-associated antigens on cord blood lymphocytes and phytohemagglutinin-stimulated blasts.
Cancer Res. 36:3471-3475(1976)

PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157
Eric H. Westin, Robert Charles Gallo, Suresh K. Arya, Alessandra Eva, Lawrence M. Souza, Marcel Albert Baluda, Stuart A. Aaronson, Flossie Wong-Staal;
Differential expression of the amv gene in human hematopoietic cells.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

PubMed=6198871; DOI=10.18926/AMO/32400
Takuzo Oda, Sekiko Watanabe, Takashi Nakamura;
Type C virus particles produced in human T-cell lines derived from acute lymphoblastic leukemia and a leukemic T-lymphoid malignancy.
Acta Med. Okayama 37:529-533(1983)

PubMed=6600440; DOI=10.1007/BF02617996
Christel H. Uittenbogaart, Yael Cantor, John L. Fahey;
Growth of human malignant lymphoid cell lines in serum-free medium.
In Vitro 19:67-72(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=3495441; DOI=10.1002/eji.1830170503
Susan Kanowith-Klein, Andrew Saxon, Christel H. Uittenbogaart;
Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.
Eur. J. Immunol. 17:593-598(1987)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=2144611; DOI=10.1128/mcb.10.10.5502-5509.1990; PMCID=PMC361264
Jian Cheng, Martin Haas;
Frequent mutations in the p53 tumor suppressor gene in human leukemia T-cell lines.
Mol. Cell. Biol. 10:5502-5509(1990)

PubMed=2255914; DOI=10.1126/science.2255914
Peter D. Aplan, Donald P. Lombardi, Ann M. Ginsberg, Jeffrey Cossman, Virginia L. Bertness, Ilan R. Kirsch;
Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity.
Science 250:1426-1429(1990)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Anne Monks, Dominic A. Scudiero, Philip Skehan, Robert H. Shoemaker, Kenneth D. Paull, David T. Vistica, Curtis D. Hose, John Langley, Paul Cronise, Anne Vaigro-Wolff, Marcia Gray-Goodrich ...Show all 14 authors... , Hugh Campbell, Joseph G. Mayo, Michael R. Boyd; Show fewer authors
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

CLPUB00447
Richard A. Mulivor, Sharon F. Suchy;
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=8127147
Mats Heyman, Dan Grander, Karen Brondum-Nielsen, Britta Cederblad, Yie Liu, Bo Xu, Stefan Einhorn;
Interferon system defects in malignant T-cells.
Leukemia 8:425-434(1994)

PubMed=7630190
Mu-Xiang Zhou, Lu-Bing Gu, Charles David James, J. He, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia 9:1159-1161(1995)

PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608
Mu-Xiang Zhou, Andrew M. Yeager, Stephen D. Smith, Harry W. Findley Jr.;
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood 85:1608-1614(1995)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Reiner Siebert, Christoph P. Willers, Alexander Schramm, Alexander Fossa, Irina M. Gana Dresen, Michael J. Uppenkamp, Mohammad Resa Nowrousian, Siegfried Seeber, Bertram Opalka;
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x
Laura Borgonovo-Brandter, Mats Heyman, Omid Rasool, Y. Liu, Dan Grander, Stefan Einhorn;
p16INK4/p15INK4B gene inactivation is a frequent event in malignant T-cell lines.
Eur. J. Haematol. 56:313-318(1996)

PubMed=9108419; DOI=10.1182/blood.V89.8.2986
Harry W. Findley Jr., Lu-Bing Gu, Andrew M. Yeager, Mu-Xiang Zhou;
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood 89:2986-2993(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9331090
Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy Gene Myers, Sai-Jun Fan, Masato Mutoh, Dominic A. Scudiero, Anne Monks, Edward A. Sausville, John N. Weinstein, Stephen H. Friend ...Show all 13 authors... , Albert J. Fornace Jr., Kurt W. Kohn; Show fewer authors
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer Res. 57:4285-4300(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9557624; DOI=10.1038/sj.leu.2400976
Letizia Mattii, Roberto Barale, Mario Petrini;
Use of the comet test in the evaluation of multidrug resistance of human cell lines.
Leukemia 12:627-632(1998)

PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775
Magnus Hultdin, Elisabeth Gronlund, Karl-Frederik Norrback, E. Eriksson-Lindstrom, Tom Just, Goran Roos;
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Akira Sakai, Catherine Thieblemont, Axel Wellmann, Elaine Sarkin Jaffe, Mark Raffeld;
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

PubMed=9823951; DOI=10.1038/sj.leu.2401198
Mu-Xiang Zhou, Lu-Bing Gu, Andrew M. Yeager, Harry W. Findley Jr.;
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia 12:1756-1763(1998)

PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7
Renate Burger, Thomas E. Hansen-Hagge, Hans Gunther Drexler, Martin Gramatzki;
Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines: suggestion for classification by immunophenotype and T-cell receptor studies.
Leuk. Res. 23:19-27(1999)

PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5
Machiko Kawamura, Hiroaki Ohnishi, Shu-Xia Guo, Xiao-Ming Sheng, Masayoshi Minegishi, Ryoji Hanada, Keizo Horibe, Teruaki Hongo, Yasuhiko Kaneko, Fumio Bessho, Masayoshi Yanagisawa ...Show all 13 authors... , Takao Sekiya, Yasuhide Hayashi; Show fewer authors
Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia.
Leuk. Res. 23:115-126(1999)

PubMed=10700174; DOI=10.1038/73432
Douglas T. Ross, Uwe Scherf, Michael Bruce Eisen, Charles M. Perou, Christian Rees, Paul T. Spellman, Vishwanath R. Iyer, Stefanie S. Jeffrey, Matt van de Rijn, Mark C. Waltham, Alexander Pergamenschikov ...Show all 18 authors... , Jeffrey C.F. Lee, Deval Lashkari, Dari Shalon, Timothy Gene Myers, John N. Weinstein, David Botstein, Patrick O'Reilly Brown; Show fewer authors
Systematic variation in gene expression patterns in human cancer cell lines.
Nat. Genet. 24:227-235(2000)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=10769646
Sagrario Martin-Aragon, Suman K. Mukherjee, Barbara J. Taylor, S. Percy Ivy, Cecilia H. Fu, Veronica C. Ardi, Vassilios I. Avramis;
Cytosine arabinoside (ara-C) resistance confers cross-resistance or collateral sensitivity to other classes of anti-leukemic drugs.
Anticancer Res. 20:139-150(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11565033; DOI=10.1038/35095068
Kenneth H. Moberg, Daphne W. Bell, Doke C.R. Pronk-Wahrer, Daniel Arie Haber, Iswar K. Hariharan;
Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Nature 413:311-316(2001)

PubMed=14500364
Stefan Nagel, Maren Kaufmann, Hans Gunther Drexler, Roderick A.F. MacLeod;
The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2).
Cancer Res. 63:5329-5334(2003)

PubMed=15472075; DOI=10.1126/science.1102160
Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee, John P. Morris 4th, Lewis B. Silverman, Cheryll Sanchez-Irizarry, Stephen Charles Blacklow, Alfred Thomas Look, Jon Christopher Aster;
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science 306:269-271(2004)

PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742
Sharon Adams, Fu-Meei Robbins, Deborah Chen, Devika Wagage, Susan L. Holbeck, Herbert Carpenter Morse 3rd, David Stroncek, Francesco M. Marincola;
HLA class I and II genotype of the NCI-60 cell lines.
J. Transl. Med. 3:11.1-11.8(2005)

PubMed=31394625
Athanasios K. Anagnostopoulos, Konstantinos Vougas, Ageliki Kolialexi, Ariadni Mavrou, Michael Fountoulakis, George T. Tsangaris;
The protein profile of the human immature T-cell line CCRF-CEM.
Cancer Genomics Proteomics 2:271-299(2005)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832
Ogechi N. Ikediobi, Helen R. Davies, Graham Robert Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck ...Show all 49 authors... , Adam P. Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathan Hinton, Chris Hunter, Andy Jenkinson, David Jones, Vivian Kosmidou, Richard Lugg, Andrew Menzies, Tatiana Mironenko, Adrian Parker, Janet Perry, Keiran Martin Raine, David Richardson, Rebecca Shepherd, Alex Small, Raffaella Smith, Helen Solomon, Philip J. Stephens, Jon W. Teague, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, William C. Reinhold, John N. Weinstein, Michael Rudolf Stratton, P. Andrew Futreal, Richard Wooster; Show fewer authors
Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.
Mol. Cancer Ther. 5:2606-2612(2006)

PubMed=17117183; DOI=10.1038/sj.bjc.6603447; PMCID=PMC2360743
Alex H. Beesley, Misty-Lee Palmer, Jette Ford, Richard E. Weller, Aaron J. Cummings, Joseph R. Freitas, Martin J. Firth, Kanchana U. Perera, Nick H. de Klerk, Ursula R. Kees;
Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines.
Br. J. Cancer 95:1537-1544(2006)

PubMed=17170727; DOI=10.1038/sj.leu.2404486
Yorick Sandberg, Brenda Verhaaf, Ellen J. van Gastel-Mol, Ingrid L.M. Wolvers-Tettero, John De Vos, Roderick A.F. MacLeod, Jeroen G. Noordzij, Willem A. Dik, Jack J.M. van Dongen, Anton W. Langerak;
Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes.
Leukemia 21:230-237(2007)

PubMed=17308084; DOI=10.1158/0008-5472.CAN-06-2615
Stefan Nagel, Michaela Scherr, Alexander Kel, Klaus Hornischer, Gregory E. Crawford, Maren Kaufmann, Corinna Meyer, Hans Gunther Drexler, Roderick A.F. MacLeod;
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
Cancer Res. 67:1461-1471(2007)

PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356
Philip L. Lorenzi, William C. Reinhold, Sudhir Varma, Amy A. Hutchinson, Yves Pommier, Stephen Jacob Chanock, John N. Weinstein;
DNA fingerprinting of the NCI-60 cell line panel.
Mol. Cancer Ther. 8:713-724(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Min H. Kang, Malcolm A. Smith, Christopher L. Morton, Nino Keshelava, Peter J. Houghton, Charles Patrick Reynolds;
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108
Jean-Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Miguel Marino, Lisa J. Green, Meena I. Vora, Chirayu Patel, Josiah N. Orina, Tatiana A. Eliseeva, Vineet Singal, Raji Padmanabhan ...Show all 17 authors... , Ben Davidson, Ram Ganapathi, Anil K. Sood, Bo R. Rueda, Suresh V. Ambudkar, Michael Marc Gottesman; Show fewer authors
Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance.
Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011)

PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511
Xiao-Yang Ruan, Jean-Pierre A. Kocher, Yves Pommier, Hong-Fang Liu, William C. Reinhold;
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap trios, and relation to fragile site location.
PLoS ONE 7:e31628.1-e31628.9(2012)

PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665
Jun-Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam-Young Kang, Shin Hui Ng, Chang No Yoon, Young-Tae Chang;
Identification of cancer cell-line origins using fluorescence image-based phenomic screening.
PLoS ONE 7:e32096.1-e32096.8(2012)

PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L. Souza, Ran Kafri, Marc Wallace Kirschner, Clary B. Clish, Vamsi Krishna Mootha;
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation.
Science 336:1040-1044(2012)

PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Michael Porcu, Idoya Lahortiga, Vanessa Brys, Wilhelm Gerhard Dirks, Hilmar Quentmeier ...Show all 17 authors... , Jacqueline Cloos, Harry Cuppens, Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts; Show fewer authors
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:e38463.1-e38463.11(2012)

PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961
Ogan Demir Abaan, Eric C. Polley, Sean R. Davis, Yue-Lin J. Zhu, Sven Bilke, Robert L. Walker, Marbin A. Pineda, Yevgeniy Gindin, Yuan Jiang, William C. Reinhold, Susan L. Holbeck ...Show all 15 authors... , Richard M. Simon, James H. Doroshow, Yves Pommier, Paul S. Meltzer; Show fewer authors
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res. 73:4372-4382(2013)

PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018
Amin Moghaddas Gholami, Hannes Hahne, Zhi-Xiang Wu, Florian Johann Auer, Chen Meng, Mathias Wilhelm, Bernhard Kuster;
Global proteome analysis of the NCI-60 cell line panel.
Cell Rep. 4:609-620(2013)

PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206
Sonia C. Dolfi, Leo Li-Ying Chan, Jean Qiu, Philip M. Tedeschi, Joseph Rocco Bertino, Kim Marie Hirshfield, Zoltan Nagy Oltvai, Alexei Vazquez;
The metabolic demands of cancer cells are coupled to their size and protein synthesis rates.
Cancer Metab. 1:20.1-20.13(2013)

PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786
Sudhir Varma, Yves Pommier, Margot Sunshine, John N. Weinstein, William C. Reinhold;
High resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMiner.
PLoS ONE 9:e92047.1-e92047.15(2014)

PubMed=25070259; DOI=10.1186/1471-2407-14-547; PMCID=PMC4122765
Takahiro Yamauchi, Kanako Uzui, Rie Nishi, Hiroko Shigemi, Takanori Ueda;
Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line.
BMC Cancer 14:547.1-547.9(2014)

PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877
Pieter Mestdagh, Steve Lefever, Pieter-Jan Volders, Stefaan Derveaux, Jan Hellemans, Jo Vandesompele;
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052.1-160052.6(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121
John G. Zampella, Nemanja Rodic, Wan Rou Yang, Cheng Ran Lisa Huang, Jane Welch, Veena P. Gnanakkan, Toby Charles Cornish, Jef D. Boeke, Kathleen H. Burns;
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29718670; DOI=10.1021/acs.jproteome.8b00165; PMCID=PMC6670293
David J. Clark, Ying-Wei Hu, William Bocik, Li-Jun Chen, Michael Schnaubelt, Rhonda R. Roberts, Punit Shah, Gordon R. Whiteley, Hui Zhang;
Evaluation of NCI-7 cell line panel as a reference material for clinical proteomics.
J. Proteome Res. 17:2205-2215(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194
Mark W. Kunkel, Nathan P. Coussens, Joel Morris, Ronald C. Taylor, Thomas S. Dexheimer, Eric M. Jones, James H. Doroshow, Beverly A. Teicher;
HTS384 NCI60: the next phase of the NCI60 screen.
Cancer Res. 84:2403-2416(2024)

Cross-references
Cell line collections (Providers) AddexBio; C0003001/32
ATCC; CCL-119
ATCC; CRL-7916 - Discontinued
ATCC; CRL-8436 - Discontinued
ATCC; CRM-CCL-119
BCRC; 60137
BCRJ; 0063
CCTCC; GDC0219
CLS; 300147
Coriell; GM03671
DSMZ; ACC-240
ECACC; 85112105
IZSLER; BS TCL 11
JCRB; IFO50412
JCRB; JCRB0033
JCRB; JCRB9023
KCLB; 10119
NCBI_Iran; C105
NCI-DTP; CCRF-CEM
RCB; RCB1980
TKG; TKG 0563
Cell line databases/resources CLO; CLO_0002334
CLO; CLO_0015478
CLO; CLO_0050143
MCCL; MCC:0000096
MCCL; MCC:0000097
CLDB; cl675
CLDB; cl676
CLDB; cl677
cancercelllines; CVCL_0207
CCRID; 3101HUMTCHu147
CCRID; 4201HUM-CCTCC00219
Cell_Model_Passport; SIDM00121
Cosmic-CLP; 905952
DepMap; ACH-001738
DSMZCellDive; ACC-240
IGRhCellID; CCRFCEM
IPD-IMGT/HLA; 10403
LINCS_LDP; LCL-1012
Lonza; 647
SKY/M-FISH/CGH; 2784
Anatomy/cell type resources BTO; BTO_0000736
Biological sample resources BioSample; SAMN00808493
BioSample; SAMN01821675
BioSample; SAMN03471121
BioSample; SAMN03471203
BioSample; SAMN03472050
BioSample; SAMN03472700
BioSample; SAMN03472808
BioSample; SAMN03473385
CRISP screens repositories BioGRID_ORCS_Cell_line; 1318
Chemistry resources ChEMBL-Cells; CHEMBL3307641
ChEMBL-Targets; CHEMBL382
ChEMBL-Targets; CHEMBL393
GDSC; 905952
PharmacoDB; CCRFCEM_190_2019
PubChem_Cell_line; CVCL_0207
Encyclopedic resources Wikidata; Q54809015
Experimental variables resources EFO; EFO_0002128
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM2116
GEO; GSM50193
GEO; GSM50257
GEO; GSM236780
GEO; GSM236816
GEO; GSM743457
GEO; GSM750806
GEO; GSM799345
GEO; GSM799408
GEO; GSM1153416
GEO; GSM1178011
GEO; GSM1178012
GEO; GSM1178013
GEO; GSM1181330
GEO; GSM1181347
GEO; GSM1374445
GEO; GSM1669670
GEO; GSM2124653
GEO; GSM5137708
Polymorphism and mutation databases Cosmic; 683716
Cosmic; 721708
Cosmic; 801728
Cosmic; 846384
Cosmic; 850198
Cosmic; 875863
Cosmic; 897449
Cosmic; 905952
Cosmic; 913411
Cosmic; 919157
Cosmic; 922674
Cosmic; 932765
Cosmic; 933544
Cosmic; 974251
Cosmic; 1012060
Cosmic; 1037690
Cosmic; 1044252
Cosmic; 1070703
Cosmic; 1071876
Cosmic; 1092595
Cosmic; 1115588
Cosmic; 1118462
Cosmic; 1127261
Cosmic; 1151774
Cosmic; 1175854
Cosmic; 1176599
Cosmic; 1191691
Cosmic; 1224367
Cosmic; 1226857
Cosmic; 1247870
Cosmic; 1281365
Cosmic; 1305336
Cosmic; 1330503
Cosmic; 1375587
Cosmic; 1483363
Cosmic; 1509201
Cosmic; 1523831
Cosmic; 1524793
Cosmic; 1639635
Cosmic; 1664520
Cosmic; 1760519
Cosmic; 1998437
Cosmic; 2165706
Cosmic; 2301560
Cosmic; 2361364
Cosmic; 2433754
Cosmic; 2458763
Cosmic; 2462863
Cosmic; 2602911
Cosmic; 2649235
Cosmic; 2649237
Cosmic; 2668294
IARC_TP53; 13197
IARC_TP53; 21218
Progenetix; CVCL_0207
Proteomic databases PRIDE; PXD005940
PRIDE; PXD005942
PRIDE; PXD005946
PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number51