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Cellosaurus ARAC-8D (CVCL_GZ10)

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Cell line name ARAC-8D
Synonyms CCRF-CEM-AraC-8D; CEM-AraC-8D; AraC-8D; Ara-C/8D
Accession CVCL_GZ10
Resource Identification Initiative To cite this cell line use: ARAC-8D (RRID:CVCL_GZ10)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28680; Cytarabine (Arabinosylcytosine; Ara-C).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Web pages Provider; ICOregon; 1626-C; https://web.archive.org/web/20230205100833/http://icoregon.technologypublisher.com/technology/18059
Publications

PubMed=2842332; DOI=10.1016/S0021-9258(18)37768-8
Buddy Ullman, Terry Coons, Susan Rockwell, Kathleen McCartan;
Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts.
J. Biol. Chem. 263:12391-12396(1988)

PubMed=18279955; DOI=10.1016/j.leukres.2007.12.015; PMCID=PMC2494856
Min Huang, Yan-Hong Wang, Jing-Jin Gu, Jing Yang, Karen Noel, Beverly S. Mitchell, Vern L. Schramm, Lewis M. Graves;
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H.
Leuk. Res. 32:1268-1278(2008)

Cross-references
Cell line databases/resources cancercelllines; CVCL_GZ10
Encyclopedic resources Wikidata; Q54750421
Entry history
Entry creation26-Sep-2016
Last entry update10-Apr-2025
Version number18