ID   ARAC-8D
AC   CVCL_GZ10
SY   CCRF-CEM-AraC-8D; CEM-AraC-8D; AraC-8D; Ara-C/8D
DR   Wikidata; Q54750421
RX   PubMed=2842332;
RX   PubMed=18279955;
WW   http://icoregon.technologypublisher.com/technology/18059
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28680; Cytarabine (Arabinosylcytosine; Ara-C).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from sampling site: Peripheral blood. Cell type=T-cell.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 23-06-22; Version: 13
//
RX   PubMed=2842332; DOI=10.1016/S0021-9258(18)37768-8;
RA   Ullman B., Coons T., Rockwell S., McCartan K.;
RT   "Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured
RT   human T lymphoblasts.";
RL   J. Biol. Chem. 263:12391-12396(1988).
//
RX   PubMed=18279955; DOI=10.1016/j.leukres.2007.12.015;
RA   Huang M., Wang Y., Gu J., Yang J., Noel K., Mitchell B.S.,
RA   Schramm V.L., Graves L.M.;
RT   "Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells
RT   to immucillin-H.";
RL   Leuk. Res. 32:1268-1278(2008).
//