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Cellosaurus CEM/C1 (CVCL_3496)

[Text version]
Cell line name CEM/C1
Synonyms CCRF-CEM C1; CEM-C1; CEM.C1; CEMC1
Accession CVCL_3496
Resource Identification Initiative To cite this cell line use: CEM/C1 (RRID:CVCL_3496)
Comments Population: Caucasian.
Doubling time: ~26 hours (ATCC=CRL-2265).
Selected for resistance to: ChEBI; CHEBI_27656; Camptothecin (CPT).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=12068308).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2265; IZSLER=BS TCL 160

Markers:
AmelogeninX
CSF1PO11
D5S81812,13
D7S8209,12
D13S3179,10,12 (ATCC=CRL-2265)
10,12 (IZSLER=BS TCL 160)
D16S53910,13
D21S1130,33.2,34.2
TH016,7
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=7579731
Rohit Kapoor, D. Lynn Slade, Akira Fujimori, Yves Pommier, W. Graydon Harker;
Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin.
Oncol. Res. 7:83-95(1995)

PubMed=8895760
Stephan Geley, Bernd L. Hartmann, Monika Hala, Elisabeth M.C. Strasser-Wozak, Klaus Kapelari, Reinhard Kofler;
Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.
Cancer Res. 56:5033-5038(1996)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2265
CLS; 305103
IZSLER; BS TCL 160
Cell line databases/resources CLO; CLO_0002355
cancercelllines; CVCL_3496
CCRID; 3101HUMTCHu212
Cell_Model_Passport; SIDM01256
IGRhCellID; CEMC1
LINCS_LDP; LCL-1034
Lonza; 241
Anatomy/cell type resources BTO; BTO_0000225
Biological sample resources BioSample; SAMN03471854
Encyclopedic resources Wikidata; Q54809269
Experimental variables resources EFO; EFO_0001667
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Cosmic; 724837
Progenetix; CVCL_3496
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39