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Cellosaurus CCRF/VCR1000 (CVCL_D546)

[Text version]
Cell line name CCRF/VCR1000
Synonyms CCRF VCR1000; CCRF-VCR 1000; CCRF VCR 1000; CCRF-CEM/VCR-1000; CEM-VCR 1000; CEM/VCR1000; VCR1000
Accession CVCL_D546
Resource Identification Initiative To cite this cell line use: CCRF/VCR1000 (RRID:CVCL_D546)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=1698543
Kimmig A., Gekeler V., Neumann M., Frese G., Handgretinger R., Kardos G., Diddens H., Niethammer D.
Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells.
Cancer Res. 50:6793-6799(1990)

PubMed=12482398; DOI=10.1006/bcmd.2002.0530
Efferth T., Verdorfer I., Miyachi H., Sauerbrey A., Drexler H.G., Chitambar C.R., Haber M., Gebhart E.
Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.
Blood Cells Mol. Dis. 29:1-13(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D546
Chemistry resources ChEMBL-Cells; CHEMBL3307393
ChEMBL-Targets; CHEMBL614540
PubChem_Cell_line; CVCL_D546
Encyclopedic resources Wikidata; Q54809052
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number25