| Comments |
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: 30-35 hours (PubMed=6572735); ~48 hours (DSMZ=ACC-20).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=20809971; DepMap=ACH-000432).
- Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln4045Ter (c.12133C>T); Zygosity=Heterozygous (Cosmic-CLP=910710; DepMap=ACH-000432).
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| HLA typing |
Source: PubMed=26589293
| Class I | | HLA-A | A*02:01,30:01 | | HLA-B | B*15:10,18:01 | | HLA-C | C*03:04,12:03 |
Source: DSMZCellDive=ACC-20
| Class I | | HLA-A | A*02:01:01,30:01:01 | | HLA-B | B*15:10:01,18:01:01 | | HLA-C | C*03:04:02,12:03:01 | | Class II | | HLA-DP | DPA1*01:03:01,02:01:02 | | DPB1*02:01:02,01:01:01 | | HLA-DQ | DQA1*01:02:01,01:02:02 | | DQB1*05:02:01,06:03:01 | | HLA-DR | DRA*01:01:01,01:02:02 | | DRB1*13:02:01,16:01:01 |
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| Genome ancestry |
Source: PubMed=30894373
| Origin | % genome |
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|
| African | 1.38 | | Native American | 0 | | East Asian, North | 2.14 | | East Asian, South | 0 | | South Asian | 2.51 | | European, North | 52.2 | | European, South | 41.77 |
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| Disease |
Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Children:
|
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| Sex of cell |
Male |
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| Age at sampling |
45Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): CLS=300133; Cosmic-CLP=910710; DSMZ=ACC-20
Markers:| Amelogenin | X |
| CSF1PO | 11,12 |
| D2S1338 | 24,25 |
| D3S1358 | 16,17 |
| D5S818 | 10,12 |
| D7S820 | 10,11 |
| D8S1179 | 11,12,13 (CLS=300133)
12,13 (DSMZ=ACC-20) |
| D13S317 | 8,10 |
| D16S539 | 11,13 |
| D18S51 | 12,16 |
| D19S433 | 13 |
| D21S11 | 30,32 |
| FGA | 20,24 |
| Penta D | 11 |
| Penta E | 12,16 |
| TH01 | 6,9.3 |
| TPOX | 8,10 |
| vWA | 16 |
Run an STR similarity search on this cell line |
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| Publications |
literature.
Cancer Res. 77:2784-2788(2017)
Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)
Richard G. Saul, Jan A. Kaczmarczyk, Suzanne D. Borgel, Sergio Y. Alcoser, Melinda G. Hollingshead, Young H. Lee, Donald P. Bottaro, Tara Hiltke, Gordon R. Whiteley, Naoko Takebe, Robert J. Kinders ...Show all 14 authors... , Ralph E. Parchment, Joseph E. Tomaszewski, James H. Doroshow; Show fewer authors
Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.
PLoS ONE 13:e0199361.1-e0199361.24(2018)
Cancer Cell 33:386-400.e5(2018)
Elisabeth Kremmer, Thomas Zobel, Jochen Dobner, Nicole Bleffert, Sandra Hoffmann, Dieter Willbold;
The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels.
Sci. Rep. 9:526.1-526.11(2019)
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 46 |
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