Cellosaurus cell line HyCyte BxPC-3 KO-hDTNBP1 (CVCL

Cross-references
Cell line name	HyCyte BxPC-3 KO-hDTNBP1
Synonyms	hDTNBP1 knockout BxPC-3
Accession	CVCL_F1NG
Resource Identification Initiative	To cite this cell line use: HyCyte BxPC-3 KO-hDTNBP1 (RRID:CVCL_F1NG)
Comments	Population: Caucasian. Doubling time: 36-48 hours (Hysigen=CGKO-M2747). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17328; DTNBP1. Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple_edited; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous; Note=By CRISPR/Cas9 (Hysigen=CGMU-M2185). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0186 (BxPC-3)
Sex of cell	Female
Age at sampling	61Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M2747
Entry history
Entry creation	27-Nov-2025
Last entry update	27-Nov-2025
Version number	1