ID BxPC-3 AC CVCL_0186 SY BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 DR BTO; BTO_0001861 DR CLO; CLO_0002065 DR EFO; EFO_0002709 DR MCCL; MCC:0000077 DR CLDB; cl516 DR CLDB; cl517 DR CLDB; cl518 DR AddexBio; C0018003/27 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-1687 DR BCRC; 60283 DR BCRJ; 0056 DR BioGRID_ORCS_Cell_line; 162 DR BioSample; SAMN03470942 DR BioSample; SAMN10987955 DR cancercelllines; CVCL_0186 DR CCRID; 1101HUM-PUMC000274 DR CCRID; 3101HUMTCHu012 DR Cell_Model_Passport; SIDM00132 DR CGH-DB; 161-1 DR CGH-DB; 9272-4 DR ChEMBL-Cells; CHEMBL3307637 DR ChEMBL-Targets; CHEMBL614530 DR CLS; 305031 DR Cosmic; 707248 DR Cosmic; 730531 DR Cosmic; 736269 DR Cosmic; 755301 DR Cosmic; 808164 DR Cosmic; 872995 DR Cosmic; 906693 DR Cosmic; 913310 DR Cosmic; 918055 DR Cosmic; 922251 DR Cosmic; 923165 DR Cosmic; 932515 DR Cosmic; 933516 DR Cosmic; 947403 DR Cosmic; 948372 DR Cosmic; 949321 DR Cosmic; 968108 DR Cosmic; 1006369 DR Cosmic; 1198209 DR Cosmic; 1299295 DR Cosmic; 1366281 DR Cosmic; 1477430 DR Cosmic; 1518232 DR Cosmic; 1534316 DR Cosmic; 1571773 DR Cosmic; 1644317 DR Cosmic; 1768263 DR Cosmic; 1945873 DR Cosmic; 2434095 DR Cosmic; 2820476 DR Cosmic-CLP; 906693 DR DepMap; ACH-000535 DR DSMZ; ACC-760 DR DSMZCellDive; ACC-760 DR ECACC; 93120816 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 906693 DR GEO; GSM206447 DR GEO; GSM621894 DR GEO; GSM784699 DR GEO; GSM886896 DR GEO; GSM887961 DR GEO; GSM1024397 DR GEO; GSM1374415 DR GEO; GSM1374416 DR GEO; GSM1374417 DR GEO; GSM1588608 DR GEO; GSM1588620 DR GEO; GSM1669634 DR GEO; GSM1906991 DR GEO; GSM1906992 DR GEO; GSM1906993 DR IARC_TP53; 312 DR ICLC; HTL96011 DR IZSLER; BS TCL 4 DR KCB; KCB 200428YJ DR LiGeA; CCLE_491 DR LINCS_LDP; LCL-1731 DR Lonza; 1013 DR PharmacoDB; BxPC3_149_2019 DR PRIDE; PXD003198 DR PRIDE; PXD030304 DR PRIDE; PXD032263 DR Progenetix; CVCL_0186 DR PubChem_Cell_line; CVCL_0186 DR SKY/M-FISH/CGH; 1995 DR TOKU-E; 707 DR Ubigene; YC-C015 DR Wikidata; Q54798758 RX DOI=10.22029/jlupub-12385; RX DOI=10.4172/2324-9293.1000104; RX PubMed=1630814; RX PubMed=1764370; RX PubMed=3754176; RX PubMed=7961102; RX PubMed=8026879; RX PubMed=8194712; RX PubMed=8286197; RX PubMed=8426738; RX PubMed=9788440; RX PubMed=10027410; RX PubMed=10408907; RX PubMed=11115575; RX PubMed=11169959; RX PubMed=12692724; RX PubMed=15126341; RX PubMed=15367885; RX PubMed=15688027; RX PubMed=16912165; RX PubMed=18298655; RX PubMed=18380791; RX PubMed=20037478; RX PubMed=20164919; RX PubMed=20418756; RX PubMed=21607521; RX PubMed=22460905; RX PubMed=22585861; RX PubMed=25167228; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=26216984; RX PubMed=26589293; RX PubMed=27073551; RX PubMed=27229158; RX PubMed=27259358; RX PubMed=27397505; RX PubMed=27910856; RX PubMed=28196595; RX PubMed=29444439; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=32782605; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; Pawefish; -; https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/BxPC-3.html WW Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=63 WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/BxPC-3 WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/pancreatic-xenograft-models/bxpc-3-xenograft-model/ WW Provider; BRICS; BRICS0125; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3928 CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: KuDOS 95 cell line panel. CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC Doubling time: 48-60 hours (PubMed=3754176); 48 hours (PubMed=25984343); ~48 hours (DSMZ=ACC-760). CC HLA typing: A*01:01,01:01; B*37:01,37:01; C*06:02,06:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=11169959). CC Sequence variation: Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (PubMed=9788440; PubMed=10408907; PubMed=15367885; PubMed=18380791). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (Cosmic-CLP=906693; DepMap=ACH-000535). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; None_reported; -; Zygosity=- (PubMed=8026879; PubMed=11115575; PubMed=15367885). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (PubMed=1630814; PubMed=7961102; PubMed=8026879; PubMed=8194712; PubMed=8426738; PubMed=11115575; PubMed=15367885; PubMed=21607521; Cosmic-CLP=906693; DepMap=ACH-000535). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Metabolomics. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.55%; Native American=0%; East Asian, North=1.41%; East Asian, South=0%; South Asian=0%; European, North=69.25%; European, South=27.79% (PubMed=30894373). CC Caution: Additional TP53 mutation in c.793C>T indicated incorrectly in PubMed=1630814. CC Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. ST Source(s): AddexBio=C0018003/27; ATCC=CRL-1687; CCRID; Cosmic-CLP=906693; DSMZ=ACC-760; ECACC=93120816; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 13 ST D12S391: 20 ST D13S317: 11 ST D16S539: 9,11 ST D18S51: 12 ST D19S433: 13 (DSMZ=ACC-760) ST D19S433: 13,16.2 (ATCC=CRL-1687; CCRID) ST D21S11: 29 ST D2S1338: 17,19 ST D2S441: 12,14 ST D3S1358: 14,16 ST D5S818: 11 ST D6S1043: 12 ST D7S820: 10,13 ST D8S1179: 13 ST FGA: 20,21 ST Penta D: 14 ST Penta E: 12,14 ST TH01: 9 ST TPOX: 8 ST vWA: 14,18 DI NCIt; C9120; Pancreatic ductal adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 61Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 48 CH CVCL_E4NF ! Bx-GEM50 CH CVCL_E8JC ! BxPC-3 human CCR5 CH CVCL_XZ31 ! BxPC-3 human CLDN18.2 CH CVCL_E8JD ! BxPC-3 human GPRC5D CH CVCL_E8JB ! BxPC-3 human GPRC5D-HA CH CVCL_E8JE ! BxPC-3 human SLC39A6 CH CVCL_E2X4 ! BxPC-3 SMAD2 KO CH CVCL_E2X5 ! BxPC-3 SMAD2/SMAD3 DKO CH CVCL_E2X6 ! BxPC-3 SMAD3 KO CH CVCL_E4N8 ! BxPC-3 XL-1 CH CVCL_C8WD ! BxPC-3-EGFP CH CVCL_C8WE ! BxPC-3-Luc CH CVCL_J246 ! BxPC-3-Luc#2 CH CVCL_5J14 ! BxPc-3-luc2 CH CVCL_XX78 ! BxPC3-R CH CVCL_5I88 ! BxPC3-Red-FLuc CH CVCL_C9DP ! BXPC-3/Cas9-hyg CH CVCL_E2Q1 ! HyCyte BxPC-3 hKRAS_p.G12D_c.35G>A CH CVCL_F1NG ! HyCyte BxPC-3 KO-hDTNBP1 CH CVCL_D6AY ! HyCyte BxPC-3 KO-hITGB6 CH CVCL_E3GX ! HyCyte BxPC-3-Luc CH CVCL_D8F1 ! Ubigene BxPC-3 GPC1 KO // RX PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C; RA Sirivatanauksorn, Vorapan RA Sirivatanauksorn, Yongyut RA Gorman, Patricia A. RA Davidson, Jeffrey M. RA Sheer, Denise RA Moore, Patrick S. RA Scarpa, Aldo RA Edwards, Paul A.W. RA Lemoine, Nicholas Robert RT "Non-random chromosomal rearrangements in pancreatic cancer cell lines RT identified by spectral karyotyping."; RL Int. J. Cancer 91:350-358(2001). // RX PubMed=12692724; DOI=10.1007/s00428-003-0784-4; RA Sipos, Bence RA Moser, Simone RA Kalthoff, Holger RA Torok, Virag RA Lohr, Johannes-Matthias RA Kloppel, Gunter RT "A comprehensive characterization of pancreatic ductal carcinoma cell RT lines: towards the establishment of an in vitro research platform."; RL Virchows Arch. 442:444-452(2003). // RX DOI=10.22029/jlupub-12385; RA Oberlin, Laura RT "Treatment of pancreatic carcinoma cell lines in vitro and vivo with a RT monoclonal antibody against the transferrin receptor."; RL Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany. // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721; RA Calhoun, Eric S. RA Hucl, Tomas RA Gallmeier, Eike RA West, Kristen M. RA Arking, Dan E. RA Maitra, Anirban RA Iacobuzio-Donahue, Christine A. RA Chakravarti, Aravinda RA Hruban, Ralph H. RA Kern, Scott E. RT "Identifying allelic loss and homozygous deletions in pancreatic RT cancer without matched normals using high-density single-nucleotide RT polymorphism arrays."; RL Cancer Res. 66:7920-7928(2006). // RX PubMed=20037478; DOI=10.4161/cbt.8.21.9685; PMCID=PMC2824894; RA Kent, Oliver A. RA Mullendore, Michael E. RA Wentzel, Eric A. RA Lopez-Romero, Pedro RA Tan, Aik-Choon RA Alvarez, Hector RA West, Kristen M. RA Ochs, Michael F. RA Hidalgo, Manuel RA Arking, Dan E. RA Maitra, Anirban RA Mendell, Joshua T. RT "A resource for analysis of microRNA expression and function in RT pancreatic ductal adenocarcinoma cells."; RL Cancer Biol. Ther. 8:2013-2024(2009). // RX PubMed=27259358; DOI=10.1074/mcp.M116.058313; PMCID=PMC4974343; RA Humphrey, Emily S. RA Su, Shih-Ping RA Nagrial, Adnan M. RA Hochgrafe, Falko RA Pajic, Marina RA Lehrbach, Gillian M. RA Parton, Robert G. RA Yap, Alpha S. RA Horvath, Lisa G. RA Chang, David K. RA Biankin, Andrew Victor RA Wu, Jian-Min RA Daly, Roger John RT "Resolution of novel pancreatic ductal adenocarcinoma subtypes by RT global phosphotyrosine profiling."; RL Mol. Cell. Proteomics 15:2671-2685(2016). // RX PubMed=8426738; RA Kalthoff, Holger RA Schmiegel, Wolff Helmut RA Roeder, Christian RA Kasche, Daniela RA Schmidt, Andreas RA Lauer, Georg RA Thiele, Heinz-Gunter RA Honold, Georg RA Pantel, Klaus RA Riethmuller, Gert RA Scherer, Ewalt RA Maurer, Julian RA Maacke, Heiko RA Deppert, Wolfgang RT "p53 and K-RAS alterations in pancreatic epithelial cell lesions."; RL Oncogene 8:289-298(1993). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826; RA Yuan, Tina L. RA Amzallag, Arnaud RA Bagni, Rachel RA Yi, Ming RA Afghani, Shervin RA Burgan, William RA Fer, Nicole RA Strathern, Leslie A. RA Powell, Katie RA Smith, Brian RA Waters, Andrew Michael RA Drubin, David Alan RA Thomson, Ty RA Liao, Rosy RA Greninger, Patricia RA Stein, Giovanna T. RA Murchie, Ellen RA Cortez, Eliane RA Egan, Regina K. RA Procter, Lauren RA Bess, Matthew RA Cheng, Kwong Tai RA Lee, Chih-Shia RA Lee, Liam Changwoo RA Fellmann, Christof RA Stephens, Robert RA Luo, Ji RA Lowe, Scott William RA Benes, Cyril Henri RA McCormick, Frank RT "Differential effector engagement by oncogenic KRAS."; RL Cell Rep. 22:1889-1902(2018). // RX PubMed=7961102; DOI=10.1111/j.1349-7006.1994.tb02898.x; PMCID=PMC5919355; RA Suwa, Hirofumi RA Yoshimura, Tsunehiro RA Yamaguchi, Nozomi RA Kanehira, Kazunori RA Manabe, Tadao RA Imamura, Masayuki RA Hiai, Hiroshi RA Fukumoto, Manabu RT "K-ras and p53 alterations in genomic DNA and transcripts of human RT pancreatic adenocarcinoma cell lines."; RL Jpn. J. Cancer Res. 85:1005-1014(1994). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=32782605; DOI=10.3892/ol.2020.11825; PMCID=PMC7400074; RA Takagi, Kohji RA Imura, Johji RA Shimomura, Akiko RA Noguchi, Akira RA Minamisaka, Takashi RA Tanaka, Shinichi RA Nishida, Takeshi RA Hatta, Hideki RA Nakajima, Takahiko RT "Establishment of highly invasive pancreatic cancer cell lines and the RT expression of IL-32."; RL Oncol. Lett. 20:2888-2896(2020). // RX PubMed=21607521; DOI=10.3892/or.1.6.1223; RA Iguchi, Haruo RA Morita, Ryoji RA Yasuda, Daisuke RA Takayanagi, Ryoichi RA Ikeda, Yurika RA Takada, Yutaka RA Shimazoe, Takao RA Nawata, Hajime RA Kono, Akira RT "Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in RT human pancreatic cancer-derived cell-lines with different metastatic RT potential."; RL Oncol. Rep. 1:1223-1227(1994). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895; RA Pilarsky, Christian RA Ammerpohl, Ole RA Sipos, Bence RA Dahl, Edgar RA Hartmann, Arndt RA Wellmann, Axel RA Braunschweig, Till RA Lohr, Johannes-Matthias RA Jesenofsky, Ralf RA Friess, Helmut RA Wente, Moritz Nicolas RA Kristiansen, Glen RA Jahnke, Beatrix RA Denz, Axel RA Ruckert, Felix RA Schackert, Hans Konrad RA Kloppel, Gunter RA Kalthoff, Holger RA Saeger, Hans-Detlev RA Grutzmann, Robert RT "Activation of Wnt signalling in stroma from pancreatic cancer RT identified by gene expression profiling."; RL J. Cell. Mol. Med. 12:2823-2835(2008). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=1630814; RA Ruggeri, Bruce Anthony RA Zhang, Shi-Yu RA Caamano, Jorge H. RA DiRado, Marion RA Flynn, Stuart Dale RA Klein-Szanto, Andres J.P. RT "Human pancreatic carcinomas and cell lines reveal frequent and RT multiple alterations in the p53 and Rb-1 tumor-suppressor genes."; RL Oncogene 7:1503-1511(1992). // RX PubMed=10027410; DOI=10.1016/S0002-9440(10)65298-4; PMCID=PMC1850008; RA Ghadimi, B. Michael RA Schrock, Evelin RA Walker, Robert L. RA Wangsa, Danny RA Jauho, Annukka RA Meltzer, Paul S. RA Ried, Thomas RT "Specific chromosomal aberrations and amplification of the AIB1 RT nuclear receptor coactivator gene in pancreatic carcinomas."; RL Am. J. Pathol. 154:525-536(1999). // RX PubMed=27073551; DOI=10.3892/ol.2016.4289; PMCID=PMC4812595; RA Fujiwara, Masaya RA Kanayama, Kazuki RA Hirokawa, Yoshifumi S. RA Shiraishi, Taizo RT "ASF-4-1 fibroblast-rich culture increases chemoresistance and mTOR RT expression of pancreatic cancer BxPC-3 cells at the invasive front in RT vitro, and promotes tumor growth and invasion in vivo."; RL Oncol. Lett. 11:2773-2779(2016). // RX PubMed=9788440; DOI=10.1038/sj.onc.1202118; RA Villanueva, Alberto RA Garcia, Carmen RA Paules Blazquez, Ana Belen RA Vicente, Monica RA Megias, Montse RA Reyes, German RA de Villalonga, Priam RA Agell, Neus RA Lluis, Felix RA Bachs, Oriol RA Capella, Gabriel RT "Disruption of the antiproliferative TGF-beta signaling pathways in RT human pancreatic cancer cells."; RL Oncogene 17:1969-1978(1998). // RX PubMed=8026879; DOI=10.1002/ijc.2910580207; RA Berrozpe, Georgina RA Schaeffer, James RA Peinado, Miguel Angel RA Real, Francisco X. RA Perucho, Manuel RT "Comparative analysis of mutations in the p53 and K-ras genes in RT pancreatic cancer."; RL Int. J. Cancer 58:185-191(1994). // RX PubMed=27229158; DOI=10.1038/cgt.2016.23; PMCID=PMC5007605; RA Schreiber, Roberto RA Mezencev, Roman RA Matyunina, Lilya V. RA McDonald, John F. RT "Evidence for the role of microRNA 374b in acquired cisplatin RT resistance in pancreatic cancer cells."; RL Cancer Gene Ther. 23:241-245(2016). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=11115575; DOI=10.3892/or.8.1.89; RA Sun, Chun-Lan RA Yamato, Takashi RA Furukawa, Toru RA Ohnishi, Yasuyuki RA Kijima, Hiroshi RA Horii, Akira RT "Characterization of the mutations of the K-ras, p53, p16, and SMAD4 RT genes in 15 human pancreatic cancer cell lines."; RL Oncol. Rep. 8:89-92(2001). // RX PubMed=8286197; DOI=10.1038/bjc.1994.24; PMCID=PMC1968784; RA Lohr, Johannes-Matthias RA Trautmann, Birgit RA Gottler, Martin RA Peters, Shirley RA Zauner, Ira RA Maillet, Bernard RA Kloppel, Gunter RT "Human ductal adenocarcinomas of the pancreas express extracellular RT matrix proteins."; RL Br. J. Cancer 69:144-151(1994). // RX PubMed=20418756; DOI=10.1097/MPA.0b013e3181c15963; PMCID=PMC2860631; RA Deer, Emily L. RA Gonzalez-Hernandez, Jessica RA Coursen, Jill D. RA Shea, Jill E. RA Ngatia, Josephat Gichuhi RA Scaife, Courtney Lynne RA Firpo, Matthew A. RA Mulvihill, Sean Jordan RT "Phenotype and genotype of pancreatic cancer cell lines."; RL Pancreas 39:425-435(2010). // RX PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732; RA Hamidi, Habib RA Lu, Ming RA Chau, Kevin RA Anderson, Lee RA Fejzo, Marlena Schoenberg RA Ginther, Charles RA Linnartz, Ronald RA Zubel, Angela RA Slamon, Dennis Joseph RA Finn, Richard Samuel RT "KRAS mutational subtype and copy number predict in vitro response of RT human pancreatic cancer cell lines to MEK inhibition."; RL Br. J. Cancer 111:1788-1801(2014). // RX PubMed=15367885; DOI=10.1097/00006676-200410000-00004; RA Loukopoulos, Panayiotis RA Kanetaka, Kengo RA Takamura, Masaaki RA Shibata, Tatsuhiro RA Sakamoto, Michiie RA Hirohashi, Setsuo RT "Orthotopic transplantation models of pancreatic adenocarcinoma RT derived from cell lines and primary tumors and displaying varying RT metastatic activity."; RL Pancreas 29:193-203(2004). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=10408907; DOI=10.1016/S0304-3835(98)00380-2; RA Bartsch, Detlef K. RA Barth, Peter RA Bastian, Daniel RA Ramaswamy, Annette RA Gerdes, Berthold RA Chaloupka, Brunhilde RA Deiss, Yvonne RA Simon, Babette RA Schudy, Andreas RT "Higher frequency of DPC4/Smad4 alterations in pancreatic cancer cell RT lines than in primary pancreatic adenocarcinomas."; RL Cancer Lett. 139:43-49(1999). // RX PubMed=27910856; DOI=10.1038/cgt.2016.71; PMCID=PMC5159445; RA Mezencev, Roman RA Matyunina, Lilya V. RA Wagner, G.T. RA McDonald, John F. RT "Acquired resistance of pancreatic cancer cells to cisplatin is RT multifactorial with cell context-dependent involvement of resistance RT genes."; RL Cancer Gene Ther. 23:446-453(2016). // RX PubMed=3754176; DOI=10.3109/07357908609039823; RA Tan, Mong H. RA Nowak, Norma Jean RA Loor, Rueyming RA Ochi, Hisako RA Sandberg, Avery Aba RA Lopez, Cecelia RA Pickren, John W. RA Berjian, Richard A. RA Douglass, Harold Orth Jr. RA Chu, Tsann Ming RT "Characterization of a new primary human pancreatic tumor line."; RL Cancer Invest. 4:15-23(1986). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX DOI=10.4172/2324-9293.1000104; RA Wagenhauser, Markus Udo RA Ruckert, Felix RA Niedergethmann, Marco RA Grutzmann, Robert RA Saeger, Hans-Detlev RT "Distribution of characteristic mutations in native ductal RT adenocarcinoma of the pancreas and pancreatic cancer cell lines."; RL Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013). // RX PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874; RA Barton, Claire M. RA Staddon, Susan Louise RA Hughes, Christine M. RA Hall, Peter A. RA O'Sullivan, Catriona RA Kloppel, Gunter RA Theis, Belinda RA Russell, Ronald Christopher Gordon RA Neoptolemos, John P. RA Williamson, Robin Charles Noel RA Lane, David Philip RA Lemoine, Nicholas Robert RT "Abnormalities of the p53 tumour suppressor gene in human pancreatic RT cancer."; RL Br. J. Cancer 64:1076-1082(1991). // RX PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396; RA Marcotte, Richard RA Brown, Kevin R. RA Suarez Saiz, Fernando Jose RA Sayad, Azin RA Karamboulas, Konstantina RA Krzyzanowski, Paul M. RA Sircoulomb, Fabrice RA Medrano, Mauricio RA Fedyshyn, Yaroslav RA Koh, Judice Lie-Yong RA van Dyk, Dewald RA Fedyshyn, Bohdana RA Luhova, Marianna RA Brito, Glauber C. RA Vizeacoumar, Franco J. RA Vizeacoumar, Frederick S. RA Datti, Alessandro RA Kasimer, Dahlia RA Buzina, Alla RA Mero, Patricia RA Misquitta, Christine RA Normand, Josee RA Haider, Maliha RA Ketela, Troy RA Wrana, Jeffrey L. RA Rottapel, Robert RA Neel, Benjamin G. RA Moffat, Jason RT "Essential gene profiles in breast, pancreatic, and ovarian cancer RT cells."; RL Cancer Discov. 2:172-189(2012). // RX PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616; RA Daemen, Anneleen RA Peterson, David RA Sahu, Nisebita RA McCord, Ron RA Du, Xiang-Nan RA Liu, Bonnie RA Kowanetz, Katarzyna RA Hong, Rebecca RA Moffat, John RA Gao, Min RA Boudreau, Aaron RA Mroue, Rana RA Corson, Laura RA O'Brien, Thomas RA Qing, Jing RA Sampath, Deepak RA Merchant, Mark RA Yauch, Robert L. RA Manning, Gerard RA Settleman, Jeffrey RA Hatzivassiliou, Georgia RA Evangelista, Marie RT "Metabolite profiling stratifies pancreatic ductal adenocarcinomas RT into subtypes with distinct sensitivities to metabolic inhibitors."; RL Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015). // RX PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159; RA Heidenblad, Markus RA Schoenmakers, Eric F.P.M. RA Jonson, Tord RA Gorunova, Ludmila RA Veltman, Joris Andre RA van Kessel, Ad Geurts RA Hoglund, Mattias RT "Genome-wide array-based comparative genomic hybridization reveals RT multiple amplification targets and novel homozygous deletions in RT pancreatic carcinoma cell lines."; RL Cancer Res. 64:3052-3059(2004). // RX PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7; RA Simon, Babette RA Weinel, Rolf RA Hohne, Martin RA Watz, Jutta RA Schmidt, Jorg RA Kortner, Gunther RA Arnold, Rudolf RT "Frequent alterations of the tumor suppressor genes p53 and DCC in RT human pancreatic carcinoma."; RL Gastroenterology 106:1645-1651(1994). // RX PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928; RA Suzuki, Ayako RA Shibata, Tatsuhiro RA Shimada, Yutaka RA Murakami, Yoshinori RA Horii, Akira RA Shiratori, Keiko RA Hirohashi, Setsuo RA Inazawa, Johji RA Imoto, Issei RT "Identification of SMURF1 as a possible target for 7q21.3-22.1 RT amplification detected in a pancreatic cancer cell line by in-house RT array-based comparative genomic hybridization."; RL Cancer Sci. 99:986-994(2008). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=15688027; DOI=10.1038/sj.onc.1208383; RA Heidenblad, Markus RA Lindgren, David RA Veltman, Joris Andre RA Jonson, Tord RA Mahlamaki, Eija H. RA Gorunova, Ludmila RA van Kessel, Ad Geurts RA Schoenmakers, Eric F.P.M. RA Hoglund, Mattias RT "Microarray analyses reveal strong influence of DNA copy number RT alterations on the transcriptional patterns in pancreatic cancer: RT implications for the interpretation of genomic amplifications."; RL Oncogene 24:1794-1801(2005). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). //