Cellosaurus cell line BxPC3-R (CVCL

Cellosaurus BxPC3-R (CVCL_XX78)

Cross-references
Cell line name	BxPC3-R
Accession	CVCL_XX78
Resource Identification Initiative	To cite this cell line use: BxPC3-R (RRID:CVCL_XX78)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP). Omics: Transcriptomics; Microarray. Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; None_reported; -; Zygosity=- (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0186 (BxPC-3)
Sex of cell	Female
Age at sampling	61Y
Category	Cancer cell line
Publications	PubMed=27229158; DOI=10.1038/cgt.2016.23; PMCID=PMC5007605 Roberto Schreiber, Roman Mezencev, Lilya V. Matyunina, John F. McDonald; Evidence for the role of microRNA 374b in acquired cisplatin resistance in pancreatic cancer cells. Cancer Gene Ther. 23:241-245(2016) PubMed=27910856; DOI=10.1038/cgt.2016.71; PMCID=PMC5159445 Roman Mezencev, Lilya V. Matyunina, G.T. Wagner, John F. McDonald; Acquired resistance of pancreatic cancer cells to cisplatin is multifactorial with cell context-dependent involvement of resistance genes. Cancer Gene Ther. 23:446-453(2016)
Cell line databases/resources	cancercelllines; CVCL_XX78
Encyclopedic resources	Wikidata; Q93433506
Gene expression databases	GEO; GSM1906994 GEO; GSM1906995 GEO; GSM1906996
Entry history
Entry creation	19-Dec-2019
Last entry update	10-Apr-2025
Version number	10