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Cellosaurus BxPC3-R (CVCL_XX78)

[Text version]
Cell line name BxPC3-R
Accession CVCL_XX78
Resource Identification Initiative To cite this cell line use: BxPC3-R (RRID:CVCL_XX78)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0186 (BxPC-3)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line

PubMed=27229158; DOI=10.1038/cgt.2016.23
Schreiber R., Mezencev R., Matyunina L.V., McDonald J.F.
Evidence for the role of microRNA 374b in acquired cisplatin resistance in pancreatic cancer cells.
Cancer Gene Ther. 23:241-245(2016)

PubMed=27910856; DOI=10.1038/cgt.2016.71
Mezencev R., Matyunina L.V., Wagner G.T., McDonald J.F.
Acquired resistance of pancreatic cancer cells to cisplatin is multifactorial with cell context-dependent involvement of resistance genes.
Cancer Gene Ther. 23:446-453(2016)

Cell line databases/resources cancercelllines; CVCL_XX78
Encyclopedic resources Wikidata; Q93433506
Gene expression databases GEO; GSM1906994
GEO; GSM1906995
GEO; GSM1906996
Entry history
Entry creation19-Dec-2019
Last entry update05-Oct-2023
Version number8